Reactome | Negative regulation of FGFR3 signaling

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Negative regulation of FGFR3 signaling Show undefined attributes

authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654731] Rothfels, Karen, 2014-12-03
crossReference	[DatabaseIdentifier:12819433] BioModels Database:BIOMD0000000653 [DatabaseIdentifier:12819435] BioModels Database:BIOMD0000000656 [DatabaseIdentifier:12819437] BioModels Database:BIOMD0000000648 [DatabaseIdentifier:12819441] BioModels Database:BIOMD0000000655 [DatabaseIdentifier:12819443] BioModels Database:BIOMD0000000652 [DatabaseIdentifier:12819445] BioModels Database:BIOMD0000000654
dbId	5654732
deleted	[Deleted:5655582] Deletion of instance: 1270470
displayName	Negative regulation of FGFR3 signaling
eventOf	[Pathway:R-HSA-5654741] Signaling by FGFR3 - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5654565] Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2 - Homo sapiens [Reaction:R-HSA-5654730] p-CBL:GRB2 binds p-FRS2:activated FGFR3 - Homo sapiens [Reaction:R-HSA-5654679] CBL ubiquitinates FRS2 and FGFR3 - Homo sapiens [Pathway:R-HSA-1295596] Spry regulation of FGF signaling - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:1549556] Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins [LiteratureReference:1296088] Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease [LiteratureReference:1268080] FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl [LiteratureReference:1268103] Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function
maxDepth	3
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Negative regulation of FGFR3 signaling
orthologousEvent	[Pathway:R-BTA-5654732] Negative regulation of FGFR3 signaling - Bos taurus [Pathway:R-CEL-5654732] Negative regulation of FGFR3 signaling - Caenorhabditis elegans [Pathway:R-DME-5654732] Negative regulation of FGFR3 signaling - Drosophila melanogaster [Pathway:R-GGA-5654732] Negative regulation of FGFR3 signaling - Gallus gallus [Pathway:R-XTR-5654732] Negative regulation of FGFR3 signaling - Xenopus tropicalis [Pathway:R-DRE-5654732] Negative regulation of FGFR3 signaling - Danio rerio [Pathway:R-SSC-5654732] Negative regulation of FGFR3 signaling - Sus scrofa [Pathway:R-CFA-5654732] Negative regulation of FGFR3 signaling - Canis familiaris [Pathway:R-RNO-5654732] Negative regulation of FGFR3 signaling - Rattus norvegicus [Pathway:R-MMU-5654732] Negative regulation of FGFR3 signaling - Mus musculus
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5654732
summation	[Summation:1503116] Once activated, the FGFR signaling pathway is regulated by n...
updateTrackers	[UpdateTracker:9775892] Update Tracker - [Pathway:5654732] Negative regulation of FGFR3 signaling - v78:[updateIndirectRLE] [UpdateTracker:9864339] Update Tracker - [Pathway:5654732] Negative regulation of FGFR3 signaling - v88:[updateIndirectRLE] [UpdateTracker:9776109] Update Tracker - [Pathway:5654732] Negative regulation of FGFR3 signaling - v77:[updateIndirectRLE]

Referrals

(updatedInstance)	[UpdateTracker:9775892] Update Tracker - [Pathway:5654732] Negative regulation of FGFR3 signaling - v78:[updateIndirectRLE] [UpdateTracker:9864339] Update Tracker - [Pathway:5654732] Negative regulation of FGFR3 signaling - v88:[updateIndirectRLE] [UpdateTracker:9776109] Update Tracker - [Pathway:5654732] Negative regulation of FGFR3 signaling - v77:[updateIndirectRLE]
(replacementInstances)	[Deleted:5655582] Deletion of instance: 1270470
(hasEvent)	[Pathway:R-HSA-5654741] Signaling by FGFR3

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