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Schema
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Pathway
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Entries
Negative regulation of FGFR3 signaling
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authored
[InstanceEdit:1489508] Rothfels, K, 2011-08-15
compartment
[Compartment:70101] cytosol
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created
[InstanceEdit:5654731] Rothfels, Karen, 2014-12-03
crossReference
[DatabaseIdentifier:12325370] BioModels Database:BIOMD0000000653
[DatabaseIdentifier:12325372] BioModels Database:BIOMD0000000656
[DatabaseIdentifier:12325374] BioModels Database:BIOMD0000000648
[DatabaseIdentifier:12325378] BioModels Database:BIOMD0000000655
[DatabaseIdentifier:12325380] BioModels Database:BIOMD0000000652
[DatabaseIdentifier:12325382] BioModels Database:BIOMD0000000654
dbId
5654732
displayName
Negative regulation of FGFR3 signaling
eventOf
[Pathway:R-HSA-5654741] Signaling by FGFR3 - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-5654565] Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. - Homo sapiens
[Reaction:R-HSA-5654730] p-CBL:GRB2 binds p-FRS2:activated FGFR3 - Homo sapiens
[Reaction:R-HSA-5654679] CBL ubiquitinates FRS2 and FGFR3 - Homo sapiens
[Pathway:R-HSA-1295596] Spry regulation of FGF signaling - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1549556] Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins
[LiteratureReference:1296088] Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease
[LiteratureReference:1268080] FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl
[LiteratureReference:1268103] Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function
modified
[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name
Negative regulation of FGFR3 signaling
orthologousEvent
[Pathway:R-CFA-5654732] Negative regulation of FGFR3 signaling - Canis familiaris
[Pathway:R-DME-5654732] Negative regulation of FGFR3 signaling - Drosophila melanogaster
[Pathway:R-GGA-5654732] Negative regulation of FGFR3 signaling - Gallus gallus
[Pathway:R-XTR-5654732] Negative regulation of FGFR3 signaling - Xenopus tropicalis
[Pathway:R-DRE-5654732] Negative regulation of FGFR3 signaling - Danio rerio
[Pathway:R-SSC-5654732] Negative regulation of FGFR3 signaling - Sus scrofa
[Pathway:R-BTA-5654732] Negative regulation of FGFR3 signaling - Bos taurus
[Pathway:R-RNO-5654732] Negative regulation of FGFR3 signaling - Rattus norvegicus
[Pathway:R-MMU-5654732] Negative regulation of FGFR3 signaling - Mus musculus
releaseDate
2011-09-20
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1549563] Gotoh, N, 2011-08-26
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5654732
summation
[Summation:1503116] Once activated, the FGFR signaling pathway is regulated by n...
Referrals
(hasEvent)
[Pathway:R-HSA-5654741] Signaling by FGFR3
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