Reactome | RAF-independent MAPK1/3 activation

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RAF-independent MAPK1/3 activation Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:112400] Charalambous, M, 2004-04-29 09:21:24
crossReference	[DatabaseIdentifier:12819513] BioModels Database:BIOMD0000000251 [DatabaseIdentifier:12819501] BioModels Database:BIOMD0000000427 [DatabaseIdentifier:12819465] BioModels Database:BIOMD0000000255 [DatabaseIdentifier:12819433] BioModels Database:BIOMD0000000653 [DatabaseIdentifier:12819435] BioModels Database:BIOMD0000000656 [DatabaseIdentifier:12819473] BioModels Database:BIOMD0000000659 [DatabaseIdentifier:12819475] BioModels Database:BIOMD0000000149 [DatabaseIdentifier:12819505] BioModels Database:BIOMD0000000557 [DatabaseIdentifier:12819477] BioModels Database:BIOMD0000000651 [DatabaseIdentifier:12819437] BioModels Database:BIOMD0000000648 [DatabaseIdentifier:12819471] BioModels Database:BIOMD0000000175 [DatabaseIdentifier:12819441] BioModels Database:BIOMD0000000655 [DatabaseIdentifier:12819479] BioModels Database:BIOMD0000000288 [DatabaseIdentifier:12819443] BioModels Database:BIOMD0000000652 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12819481] BioModels Database:BIOMD0000000399 [DatabaseIdentifier:12819483] BioModels Database:BIOMD0000000019 [DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477 [DatabaseIdentifier:12819485] BioModels Database:BIOMD0000000424 [DatabaseIdentifier:12819445] BioModels Database:BIOMD0000000654
dbId	112409
displayName	RAF-independent MAPK1/3 activation
eventOf	[Pathway:R-HSA-5684996] MAPK1/MAPK3 signaling - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:396352] ERK1 and ERK2 cascade
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-110056] MAPK3 (ERK1) activation - Homo sapiens [Pathway:R-HSA-112411] MAPK1 (ERK2) activation - Homo sapiens [Reaction:R-HSA-5674385] p-T,Y MAPKs dimerize - Homo sapiens [BlackBoxEvent:R-HSA-5674387] Phosphorylated MAPKs translocate into the nucleus - Homo sapiens [Reaction:R-HSA-5675206] PEA15 binds MAPK monomers and dimers - Homo sapiens [Reaction:R-HSA-5675376] Cytosolic DUSPs dephosphorylate MAPKs - Homo sapiens [Reaction:R-HSA-5675373] Nuclear DUSPs dephosphorylate MAPKs - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:5684202] Mitogen-activated protein kinases in innate immunity [LiteratureReference:5673943] ERK1/2 MAP kinases: structure, function, and regulation [LiteratureReference:5684203] Regulation and function of TPL-2, an I?B kinase-regulated MAP kinase kinase kinase
maxDepth	3
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	RAF-independent MAPK1/3 activation
orthologousEvent	[Pathway:R-MMU-112409] RAF-independent MAPK1/3 activation - Mus musculus [Pathway:R-RNO-112409] RAF-independent MAPK1/3 activation - Rattus norvegicus [Pathway:R-CFA-112409] RAF-independent MAPK1/3 activation - Canis familiaris [Pathway:R-BTA-112409] RAF-independent MAPK1/3 activation - Bos taurus [Pathway:R-SSC-112409] RAF-independent MAPK1/3 activation - Sus scrofa [Pathway:R-DRE-112409] RAF-independent MAPK1/3 activation - Danio rerio [Pathway:R-XTR-112409] RAF-independent MAPK1/3 activation - Xenopus tropicalis [Pathway:R-GGA-112409] RAF-independent MAPK1/3 activation - Gallus gallus [Pathway:R-DME-112409] RAF-independent MAPK1/3 activation - Drosophila melanogaster [Pathway:R-CEL-112409] RAF-independent MAPK1/3 activation - Caenorhabditis elegans [Pathway:R-DDI-112409] RAF-independent MAPK1/3 activation - Dictyostelium discoideum
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-112409
summation	[Summation:211551] Depending upon the stimulus and cell type mitogen-activated ...
updateTrackers	[UpdateTracker:9791309] Update Tracker - [Pathway:112409] RAF-independent MAPK1/3 activation - v31:[updateContainedPathway] [UpdateTracker:9791040] Update Tracker - [Pathway:112409] RAF-independent MAPK1/3 activation - v32:[updateContainedPathway] [UpdateTracker:9775730] Update Tracker - [Pathway:112409] RAF-independent MAPK1/3 activation - v78:[updateIndirectRLE] [UpdateTracker:9790729] Update Tracker - [Pathway:112409] RAF-independent MAPK1/3 activation - v33:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9791898] Update Tracker - [Pathway:112409] RAF-independent MAPK1/3 activation - v25:[updateContainedPathway] [UpdateTracker:9784675] Update Tracker - [Pathway:112409] RAF-independent MAPK1/3 activation - v53:[addHasEvent, addLiteratureReference, modifyText, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9792009] Update Tracker - [Pathway:112409] RAF-independent MAPK1/3 activation - v24:[addSummation, updateContainedPathway] [UpdateTracker:9785989] Update Tracker - [Pathway:112409] RAF-independent MAPK1/3 activation - v50:[updateIndirectRLE] [UpdateTracker:9781092] Update Tracker - [Pathway:112409] RAF-independent MAPK1/3 activation - v61:[updateIndirectRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-5684996] MAPK1/MAPK3 signaling
(hasEncapsulatedEvent)	[Pathway:R-HSA-450294] MAP kinase activation
(updatedInstance)	[UpdateTracker:9791309] Update Tracker - [Pathway:112409] RAF-independent MAPK1/3 activation - v31:[updateContainedPathway] [UpdateTracker:9791040] Update Tracker - [Pathway:112409] RAF-independent MAPK1/3 activation - v32:[updateContainedPathway] [UpdateTracker:9775730] Update Tracker - [Pathway:112409] RAF-independent MAPK1/3 activation - v78:[updateIndirectRLE] [UpdateTracker:9790729] Update Tracker - [Pathway:112409] RAF-independent MAPK1/3 activation - v33:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9791898] Update Tracker - [Pathway:112409] RAF-independent MAPK1/3 activation - v25:[updateContainedPathway] [UpdateTracker:9784675] Update Tracker - [Pathway:112409] RAF-independent MAPK1/3 activation - v53:[addHasEvent, addLiteratureReference, modifyText, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9792009] Update Tracker - [Pathway:112409] RAF-independent MAPK1/3 activation - v24:[addSummation, updateContainedPathway] [UpdateTracker:9785989] Update Tracker - [Pathway:112409] RAF-independent MAPK1/3 activation - v50:[updateIndirectRLE] [UpdateTracker:9781092] Update Tracker - [Pathway:112409] RAF-independent MAPK1/3 activation - v61:[updateIndirectRLE]

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