Reactome | Negative regulation of the PI3K/AKT network

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Negative regulation of the PI3K/AKT network Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
created	[InstanceEdit:199435] Jassal, B, 2007-07-10 12:01:00
crossReference	[DatabaseIdentifier:12819465] BioModels Database:BIOMD0000000255 [DatabaseIdentifier:12819433] BioModels Database:BIOMD0000000653 [DatabaseIdentifier:12819435] BioModels Database:BIOMD0000000656 [DatabaseIdentifier:12819477] BioModels Database:BIOMD0000000651 [DatabaseIdentifier:12819437] BioModels Database:BIOMD0000000648 [DatabaseIdentifier:12819471] BioModels Database:BIOMD0000000175 [DatabaseIdentifier:12819441] BioModels Database:BIOMD0000000655 [DatabaseIdentifier:12819443] BioModels Database:BIOMD0000000652 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12819511] BioModels Database:BIOMD0000000468 [DatabaseIdentifier:12819485] BioModels Database:BIOMD0000000424 [DatabaseIdentifier:12819445] BioModels Database:BIOMD0000000654
dbId	199418
displayName	Negative regulation of the PI3K/AKT network
eventOf	[Pathway:R-HSA-1257604] PIP3 activates AKT signaling - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-199456] PTEN dephosphorylates PIP3 - Homo sapiens [Reaction:R-HSA-199443] THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation - Homo sapiens [Reaction:R-HSA-199425] PHLPP dephosphorylates S473 in AKT - Homo sapiens [Pathway:R-HSA-6811558] PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-06-22
maxDepth	3
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Negative regulation of the PI3K/AKT network
orthologousEvent	[Pathway:R-PFA-199418] Negative regulation of the PI3K/AKT network - Plasmodium falciparum [Pathway:R-SCE-199418] Negative regulation of the PI3K/AKT network - Saccharomyces cerevisiae [Pathway:R-SPO-199418] Negative regulation of the PI3K/AKT network - Schizosaccharomyces pombe [Pathway:R-DDI-199418] Negative regulation of the PI3K/AKT network - Dictyostelium discoideum [Pathway:R-CEL-199418] Negative regulation of the PI3K/AKT network - Caenorhabditis elegans [Pathway:R-DME-199418] Negative regulation of the PI3K/AKT network - Drosophila melanogaster [Pathway:R-GGA-199418] Negative regulation of the PI3K/AKT network - Gallus gallus [Pathway:R-XTR-199418] Negative regulation of the PI3K/AKT network - Xenopus tropicalis [Pathway:R-DRE-199418] Negative regulation of the PI3K/AKT network - Danio rerio [Pathway:R-SSC-199418] Negative regulation of the PI3K/AKT network - Sus scrofa [Pathway:R-BTA-199418] Negative regulation of the PI3K/AKT network - Bos taurus [Pathway:R-CFA-199418] Negative regulation of the PI3K/AKT network - Canis familiaris [Pathway:R-RNO-199418] Negative regulation of the PI3K/AKT network - Rattus norvegicus [Pathway:R-MMU-199418] Negative regulation of the PI3K/AKT network - Mus musculus
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37 [InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
revised	[InstanceEdit:2327847] Orlic-Milacic, M, 2012-06-21
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-199418
summation	[Summation:211747] The PI3K/AKT network is negatively regulated by phosphatases...
updateTrackers	[UpdateTracker:9789242] Update Tracker - [Pathway:199418] Negative regulation of the PI3K/AKT network - v38:[updateContainedRLE] [UpdateTracker:9782242] Update Tracker - [Pathway:199418] Negative regulation of the PI3K/AKT network - v59:[updateContainedRLE] [UpdateTracker:9783212] Update Tracker - [Pathway:199418] Negative regulation of the PI3K/AKT network - v57:[updateContainedRLE] [UpdateTracker:9781251] Update Tracker - [Pathway:199418] Negative regulation of the PI3K/AKT network - v61:[updateIndirectRLE] [UpdateTracker:9788377] Update Tracker - [Pathway:199418] Negative regulation of the PI3K/AKT network - v42:[updateContainedRLE] [UpdateTracker:9783721] Update Tracker - [Pathway:199418] Negative regulation of the PI3K/AKT network - v56:[addHasEvent]

Referrals

(updatedInstance)

[UpdateTracker:9789242] Update Tracker - [Pathway:199418] Negative regulation of the PI3K/AKT network - v38:[updateContainedRLE]
[UpdateTracker:9782242] Update Tracker - [Pathway:199418] Negative regulation of the PI3K/AKT network - v59:[updateContainedRLE]
[UpdateTracker:9783212] Update Tracker - [Pathway:199418] Negative regulation of the PI3K/AKT network - v57:[updateContainedRLE]
[UpdateTracker:9781251] Update Tracker - [Pathway:199418] Negative regulation of the PI3K/AKT network - v61:[updateIndirectRLE]
[UpdateTracker:9788377] Update Tracker - [Pathway:199418] Negative regulation of the PI3K/AKT network - v42:[updateContainedRLE]
[UpdateTracker:9783721] Update Tracker - [Pathway:199418] Negative regulation of the PI3K/AKT network - v56:[addHasEvent]

(hasEvent)

[Pathway:R-HSA-1257604] PIP3 activates AKT signaling

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