Reactome | AXIN missense mutants destabilize the destruction complex

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AXIN missense mutants destabilize the destruction complex Show undefined attributes

authored	[InstanceEdit:4839719] Rothfels, K, 2013-11-01
created	[InstanceEdit:5467339] Rothfels, Karen, 2014-05-16
crossReference	[DatabaseIdentifier:12325370] BioModels Database:BIOMD0000000653 [DatabaseIdentifier:12325372] BioModels Database:BIOMD0000000656 [DatabaseIdentifier:12325436] BioModels Database:BIOMD0000000149 [DatabaseIdentifier:12325374] BioModels Database:BIOMD0000000648 [DatabaseIdentifier:12325376] BioModels Database:BIOMD0000000657 [DatabaseIdentifier:12325378] BioModels Database:BIOMD0000000655 [DatabaseIdentifier:12325380] BioModels Database:BIOMD0000000652 [DatabaseIdentifier:12325382] BioModels Database:BIOMD0000000654
dbId	5467340
disease	[Disease:1500689] cancer
displayName	AXIN missense mutants destabilize the destruction complex
edited	[InstanceEdit:5358774] Matthews, Lisa, 2014-04-03
eventOf	[Pathway:R-HSA-4839735] Signaling by AXIN mutants - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[FailedReaction:R-HSA-4839734] AXIN mutants destabilize the destruction complex - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5251469] AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1 [LiteratureReference:5251510] Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas [LiteratureReference:5251487] Sequence variants of the axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding [LiteratureReference:5251479] Frequent alterations in the Wnt signaling pathway in colorectal cancer with microsatellite instability
modified	[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name	AXIN missense mutants destabilize the destruction complex
normalPathway	[Pathway:R-HSA-195253] Degradation of beta-catenin by the destruction complex
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5433076] Salahshor, S, 2014-05-12 [InstanceEdit:5545509] Woodgett, Jim, 2014-05-21
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5467340
summation	[Summation:5251523] Alterations in AXIN1 have been detected in a number of diffe...

Referrals

(hasEvent)

[Pathway:R-HSA-4839735] Signaling by AXIN mutants