Reactome | Deactivation of the beta-catenin transactivating complex

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Deactivation of the beta-catenin transactivating complex Show undefined attributes

authored	[InstanceEdit:3640727] Rothfels, K, 2013-05-29
created	[InstanceEdit:3769403] Rothfels, K, 2013-06-19
crossReference	[DatabaseIdentifier:12819433] BioModels Database:BIOMD0000000653 [DatabaseIdentifier:12819435] BioModels Database:BIOMD0000000656 [DatabaseIdentifier:12819475] BioModels Database:BIOMD0000000149 [DatabaseIdentifier:12819437] BioModels Database:BIOMD0000000648 [DatabaseIdentifier:12819441] BioModels Database:BIOMD0000000655 [DatabaseIdentifier:12819443] BioModels Database:BIOMD0000000652 [DatabaseIdentifier:12819445] BioModels Database:BIOMD0000000654
dbId	3769402
displayName	Deactivation of the beta-catenin transactivating complex
doi	10.3180/r-hsa-3769402.1
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02 [InstanceEdit:201675] Matthews, L, 2007-09-04 11:49:29
eventOf	[Pathway:R-HSA-201681] TCF dependent signaling in response to WNT - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-3322431] XIAP binds TLE - Homo sapiens [Reaction:R-HSA-3322429] XIAP monoubiquinates TLE - Homo sapiens [Reaction:R-HSA-3322434] XIAP dissociates from ub-TLE - Homo sapiens [BlackBoxEvent:R-HSA-3364042] APC promotes disassembly of beta-catenin transactivation complex - Homo sapiens [BlackBoxEvent:R-HSA-3361751] beta-catenin is replaced by repression complexes at the promoter - Homo sapiens [Reaction:R-HSA-3769383] CBY1 binds beta-catenin - Homo sapiens [Reaction:R-HSA-3769394] AKT phosphorylates CBY1 - Homo sapiens [Reaction:R-HSA-3769393] YWHAZ binds p-CBY:CTNNB1 - Homo sapiens [Reaction:R-HSA-3769391] XPO1 binds the beta-catenin:CBY complex - Homo sapiens [BlackBoxEvent:R-HSA-3769392] YWHAZ and XPO1 mediate the nuclear export of beta-catenin - Homo sapiens [Reaction:R-HSA-3772430] CTNNBIP1 binds beta-catenin - Homo sapiens [Reaction:R-HSA-5368580] CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression - Homo sapiens [Reaction:R-HSA-5626938] Beta-catenin binds SOX proteins - Homo sapiens [Reaction:R-HSA-5665608] TCF:Beta-catenin binds SOX proteins - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2015-03-23
literatureReference	[LiteratureReference:3772347] ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules [LiteratureReference:3772370] The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT [LiteratureReference:3361761] The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF [LiteratureReference:3322328] The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes [LiteratureReference:3772348] Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein [LiteratureReference:3769222] Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway [LiteratureReference:3769219] Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity [LiteratureReference:3451150] Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity [LiteratureReference:3772362] Silencing mediator for retinoid and thyroid hormone receptor and nuclear receptor corepressor attenuate transcriptional activation by the beta-catenin-TCF4 complex [LiteratureReference:3772375] The tumor suppressor Fhit acts as a repressor of beta-catenin transcriptional activity [LiteratureReference:5323435] Inactivation of Chibby affects function of motile airway cilia
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Deactivation of the beta-catenin transactivating complex
orthologousEvent	[Pathway:R-MMU-3769402] Deactivation of the beta-catenin transactivating complex - Mus musculus [Pathway:R-RNO-3769402] Deactivation of the beta-catenin transactivating complex - Rattus norvegicus [Pathway:R-CFA-3769402] Deactivation of the beta-catenin transactivating complex - Canis familiaris [Pathway:R-BTA-3769402] Deactivation of the beta-catenin transactivating complex - Bos taurus [Pathway:R-SSC-3769402] Deactivation of the beta-catenin transactivating complex - Sus scrofa [Pathway:R-DRE-3769402] Deactivation of the beta-catenin transactivating complex - Danio rerio [Pathway:R-XTR-3769402] Deactivation of the beta-catenin transactivating complex - Xenopus tropicalis [Pathway:R-GGA-3769402] Deactivation of the beta-catenin transactivating complex - Gallus gallus [Pathway:R-DME-3769402] Deactivation of the beta-catenin transactivating complex - Drosophila melanogaster [Pathway:R-CEL-3769402] Deactivation of the beta-catenin transactivating complex - Caenorhabditis elegans
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-3769402
summation	[Summation:3772457] The mechanisms involved in downregulation of TCF-dependent t...
updateTrackers	[UpdateTracker:9786459] Update Tracker - [Pathway:3769402] Deactivation of the beta-catenin transactivating complex - v49:[addHasEvent, modifyText] [UpdateTracker:9785172] Update Tracker - [Pathway:3769402] Deactivation of the beta-catenin transactivating complex - v52:[addHasEvent]

Referrals

(hasEvent)	[Pathway:R-HSA-201681] TCF dependent signaling in response to WNT
(updatedInstance)	[UpdateTracker:9786459] Update Tracker - [Pathway:3769402] Deactivation of the beta-catenin transactivating complex - v49:[addHasEvent, modifyText] [UpdateTracker:9785172] Update Tracker - [Pathway:3769402] Deactivation of the beta-catenin transactivating complex - v52:[addHasEvent]

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