Reactome | MET activates RAS signaling

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MET activates RAS signaling Show undefined attributes

authored	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
created	[InstanceEdit:8851806] Orlic-Milacic, Marija, 2016-01-11
crossReference	[DatabaseIdentifier:12819465] BioModels Database:BIOMD0000000255 [DatabaseIdentifier:12819433] BioModels Database:BIOMD0000000653 [DatabaseIdentifier:12819435] BioModels Database:BIOMD0000000656 [DatabaseIdentifier:12819437] BioModels Database:BIOMD0000000648 [DatabaseIdentifier:12819507] BioModels Database:BIOMD0000000466 [DatabaseIdentifier:12819471] BioModels Database:BIOMD0000000175 [DatabaseIdentifier:12819441] BioModels Database:BIOMD0000000655 [DatabaseIdentifier:12819443] BioModels Database:BIOMD0000000652 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12819511] BioModels Database:BIOMD0000000468 [DatabaseIdentifier:12819481] BioModels Database:BIOMD0000000399 [DatabaseIdentifier:12819483] BioModels Database:BIOMD0000000019 [DatabaseIdentifier:12819485] BioModels Database:BIOMD0000000424 [DatabaseIdentifier:12819445] BioModels Database:BIOMD0000000654
dbId	8851805
displayName	MET activates RAS signaling
edited	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
eventOf	[Pathway:R-HSA-6806834] Signaling by MET - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-8851804] Activated MET recruits GRB2-1:SOS1 - Homo sapiens [Reaction:R-HSA-8851827] RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-8851842] MUC20 binds MET and inhibits GRB2 binding - Homo sapiens [Reaction:R-HSA-8851859] Activated MET binds RANBP9 and SOS1 - Homo sapiens [Reaction:R-HSA-8851877] RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET - Homo sapiens [Reaction:R-HSA-8851866] MET binds RANBP10 - Homo sapiens [Reaction:R-HSA-8851888] MET binds SHC1-2 - Homo sapiens [Reaction:R-HSA-8851890] MET phosphorylates SHC1-2 - Homo sapiens [Reaction:R-HSA-8851900] SHC1-2 bound to MET recruits GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-8851899] RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8875784] Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation [LiteratureReference:6806997] A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family [LiteratureReference:8851815] Branching tubulogenesis but not scatter of madin-darby canine kidney cells requires a functional Grb2 binding site in the Met receptor tyrosine kinase [LiteratureReference:8851816] DDT stimulates c-erbB2, c-met, and STATS tyrosine phosphorylation, Grb2-Sos association, MAPK phosphorylation, and proliferation of human breast epithelial cells [LiteratureReference:8851812] Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2 [LiteratureReference:8851869] A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling [LiteratureReference:8851858] Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM [LiteratureReference:8866340] Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells [LiteratureReference:8851845] MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met [LiteratureReference:8931776] Down-regulation of MET, the receptor for hepatocyte growth factor [LiteratureReference:8874693] Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein [LiteratureReference:8875449] The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met [LiteratureReference:8851912] Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses [LiteratureReference:8931778] Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	MET activates RAS signaling
orthologousEvent	[Pathway:R-MMU-8851805] MET activates RAS signaling - Mus musculus [Pathway:R-RNO-8851805] MET activates RAS signaling - Rattus norvegicus [Pathway:R-CFA-8851805] MET activates RAS signaling - Canis familiaris [Pathway:R-BTA-8851805] MET activates RAS signaling - Bos taurus [Pathway:R-SSC-8851805] MET activates RAS signaling - Sus scrofa [Pathway:R-DRE-8851805] MET activates RAS signaling - Danio rerio [Pathway:R-XTR-8851805] MET activates RAS signaling - Xenopus tropicalis [Pathway:R-GGA-8851805] MET activates RAS signaling - Gallus gallus [Pathway:R-CEL-8851805] MET activates RAS signaling - Caenorhabditis elegans
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11 [InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8851805
summation	[Summation:8875785] Activated MET receptor recruits the RAS guanyl nucleotide ex...

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[Pathway:R-HSA-6806834] Signaling by MET

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