Reactome | Frs2-mediated activation

Schema > Pathway > Entries

Frs2-mediated activation Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
created	[InstanceEdit:170970] Jassal, B, 2006-01-25 09:53:37
crossReference	[DatabaseIdentifier:12325370] BioModels Database:BIOMD0000000653 [DatabaseIdentifier:12325372] BioModels Database:BIOMD0000000656 [DatabaseIdentifier:12325344] BioModels Database:BIOMD0000000664 [DatabaseIdentifier:12325374] BioModels Database:BIOMD0000000648 [DatabaseIdentifier:12325378] BioModels Database:BIOMD0000000655 [DatabaseIdentifier:12325380] BioModels Database:BIOMD0000000652 [DatabaseIdentifier:12325346] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12325382] BioModels Database:BIOMD0000000654
dbId	170968
displayName	Frs2-mediated activation
edited	[InstanceEdit:188340] Jassal, Bijay, 2006-10-10
eventOf	[Pathway:R-HSA-169893] Prolonged ERK activation events - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:21714] MAPK cascade
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-170964] FRS2 binds to active TrkA receptor - Homo sapiens [Reaction:R-HSA-170977] FRS2 is phosphorylated by active TrkA receptor - Homo sapiens [Reaction:R-HSA-170975] p-FRS2 binds CRKL - Homo sapiens [Reaction:R-HSA-170978] p-FRS2:CRKL binds C3G - Homo sapiens [Reaction:R-HSA-170979] (Frs2)C3G stimulates nucleotide exchange on Rap1 - Homo sapiens [Reaction:R-HSA-170965] (Frs2)Rap1-GTP binds to and activates B-Raf - Homo sapiens [Reaction:R-HSA-9610163] BRAF autophosphorylates downstream of RAP1 and NGF - Homo sapiens [Reaction:R-HSA-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Homo sapiens [Reaction:R-HSA-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF - Homo sapiens [Reaction:R-HSA-9610156] MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF - Homo sapiens [BlackBoxEvent:R-HSA-9610154] Dissociation of phosphorylated MAP2Ks and MAPKs - Homo sapiens [Reaction:R-HSA-5674385] p-T,Y MAPKs dimerize - Homo sapiens [BlackBoxEvent:R-HSA-9610166] p-T,Y MAPK dimers translocate to nucleus - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:190211] Signal transduction by the neurotrophin receptors
modified	[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name	Frs2-mediated activation
orthologousEvent	[Pathway:R-SSC-170968] Frs2-mediated activation - Sus scrofa [Pathway:R-PFA-170968] Frs2-mediated activation - Plasmodium falciparum [Pathway:R-SCE-170968] Frs2-mediated activation - Saccharomyces cerevisiae [Pathway:R-SPO-170968] Frs2-mediated activation - Schizosaccharomyces pombe [Pathway:R-DDI-170968] Frs2-mediated activation - Dictyostelium discoideum [Pathway:R-CEL-170968] Frs2-mediated activation - Caenorhabditis elegans [Pathway:R-DME-170968] Frs2-mediated activation - Drosophila melanogaster [Pathway:R-GGA-170968] Frs2-mediated activation - Gallus gallus [Pathway:R-XTR-170968] Frs2-mediated activation - Xenopus tropicalis [Pathway:R-DRE-170968] Frs2-mediated activation - Danio rerio [Pathway:R-BTA-170968] Frs2-mediated activation - Bos taurus [Pathway:R-CFA-170968] Frs2-mediated activation - Canis familiaris [Pathway:R-RNO-170968] Frs2-mediated activation - Rattus norvegicus [Pathway:R-MMU-170968] Frs2-mediated activation - Mus musculus
releaseDate	2007-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-170968
summation	[Summation:190214] The adaptor protein Frs2 (Fibroblast growth factor receptor ...

Referrals

(hasEvent)

[Pathway:R-HSA-169893] Prolonged ERK activation events

Cite Us!