Reactome | Frs2-mediated activation

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Frs2-mediated activation Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
created	[InstanceEdit:170970] Jassal, B, 2006-01-25 09:53:37
crossReference	[DatabaseIdentifier:12819433] BioModels Database:BIOMD0000000653 [DatabaseIdentifier:12819435] BioModels Database:BIOMD0000000656 [DatabaseIdentifier:12819429] BioModels Database:BIOMD0000000664 [DatabaseIdentifier:12819437] BioModels Database:BIOMD0000000648 [DatabaseIdentifier:12819441] BioModels Database:BIOMD0000000655 [DatabaseIdentifier:12819443] BioModels Database:BIOMD0000000652 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12819445] BioModels Database:BIOMD0000000654
dbId	170968
displayName	Frs2-mediated activation
edited	[InstanceEdit:188340] Jassal, Bijay, 2006-10-10
eventOf	[Pathway:R-HSA-169893] Prolonged ERK activation events - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:21714] MAPK cascade
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-170964] FRS2 binds to active TrkA receptor - Homo sapiens [Reaction:R-HSA-170977] FRS2 is phosphorylated by active TrkA receptor - Homo sapiens [Reaction:R-HSA-170975] p-FRS2 binds CRKL - Homo sapiens [Reaction:R-HSA-170978] p-FRS2:CRKL binds C3G - Homo sapiens [Reaction:R-HSA-170979] (Frs2)C3G stimulates nucleotide exchange on Rap1 - Homo sapiens [Reaction:R-HSA-170965] (Frs2)Rap1-GTP binds to and activates B-Raf - Homo sapiens [Reaction:R-HSA-9610163] BRAF autophosphorylates downstream of RAP1 and NGF - Homo sapiens [Reaction:R-HSA-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Homo sapiens [Reaction:R-HSA-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF - Homo sapiens [Reaction:R-HSA-9610156] MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF - Homo sapiens [BlackBoxEvent:R-HSA-9610154] Dissociation of phosphorylated MAP2Ks and MAPKs - Homo sapiens [Reaction:R-HSA-5674385] p-T,Y MAPKs dimerize - Homo sapiens [BlackBoxEvent:R-HSA-9610166] p-T,Y MAPK dimers translocate to nucleus - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-09-09
literatureReference	[LiteratureReference:190211] Signal transduction by the neurotrophin receptors
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Frs2-mediated activation
orthologousEvent	[Pathway:R-MMU-170968] Frs2-mediated activation - Mus musculus [Pathway:R-RNO-170968] Frs2-mediated activation - Rattus norvegicus [Pathway:R-CFA-170968] Frs2-mediated activation - Canis familiaris [Pathway:R-BTA-170968] Frs2-mediated activation - Bos taurus [Pathway:R-SSC-170968] Frs2-mediated activation - Sus scrofa [Pathway:R-XTR-170968] Frs2-mediated activation - Xenopus tropicalis [Pathway:R-GGA-170968] Frs2-mediated activation - Gallus gallus [Pathway:R-DME-170968] Frs2-mediated activation - Drosophila melanogaster [Pathway:R-CEL-170968] Frs2-mediated activation - Caenorhabditis elegans [Pathway:R-DDI-170968] Frs2-mediated activation - Dictyostelium discoideum [Pathway:R-DRE-170968] Frs2-mediated activation - Danio rerio
releaseDate	2007-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-170968
summation	[Summation:190214] The adaptor protein Frs2 (Fibroblast growth factor receptor ...
updateTrackers	[UpdateTracker:9787980] Update Tracker - [Pathway:170968] Frs2-mediated activation - v44:[updateContainedRLE] [UpdateTracker:9780437] Update Tracker - [Pathway:170968] Frs2-mediated activation - v63:[updateContainedRLE] [UpdateTracker:9780818] Update Tracker - [Pathway:170968] Frs2-mediated activation - v62:[removeHasEvent] [UpdateTracker:9777598] Update Tracker - [Pathway:170968] Frs2-mediated activation - v70:[addHasEvent] [UpdateTracker:9791828] Update Tracker - [Pathway:170968] Frs2-mediated activation - v25:[updateContainedRLE] [UpdateTracker:9783497] Update Tracker - [Pathway:170968] Frs2-mediated activation - v56:[updateContainedPathway] [UpdateTracker:9779257] Update Tracker - [Pathway:170968] Frs2-mediated activation - v66:[updateContainedRLE] [UpdateTracker:9784793] Update Tracker - [Pathway:170968] Frs2-mediated activation - v53:[add_removeHasEvent] [UpdateTracker:9778793] Update Tracker - [Pathway:170968] Frs2-mediated activation - v67:[addHasEvent]

Referrals

(hasEvent)

[Pathway:R-HSA-169893] Prolonged ERK activation events

(updatedInstance)

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