Reactome | Negative regulation of MAPK pathway

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Negative regulation of MAPK pathway Show undefined attributes

authored	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
created	[InstanceEdit:5675222] Rothfels, Karen, 2015-02-15
crossReference	[DatabaseIdentifier:12325470] BioModels Database:BIOMD0000000427 [DatabaseIdentifier:12325424] BioModels Database:BIOMD0000000255 [DatabaseIdentifier:12325370] BioModels Database:BIOMD0000000653 [DatabaseIdentifier:12325372] BioModels Database:BIOMD0000000656 [DatabaseIdentifier:12325472] BioModels Database:BIOMD0000000832 [DatabaseIdentifier:12325434] BioModels Database:BIOMD0000000659 [DatabaseIdentifier:12325436] BioModels Database:BIOMD0000000149 [DatabaseIdentifier:12325344] BioModels Database:BIOMD0000000664 [DatabaseIdentifier:12325438] BioModels Database:BIOMD0000000651 [DatabaseIdentifier:12325374] BioModels Database:BIOMD0000000648 [DatabaseIdentifier:12325430] BioModels Database:BIOMD0000000175 [DatabaseIdentifier:12325378] BioModels Database:BIOMD0000000655 [DatabaseIdentifier:12325440] BioModels Database:BIOMD0000000288 [DatabaseIdentifier:12325380] BioModels Database:BIOMD0000000652 [DatabaseIdentifier:12325346] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12325442] BioModels Database:BIOMD0000000399 [DatabaseIdentifier:12325444] BioModels Database:BIOMD0000000019 [DatabaseIdentifier:12325404] BioModels Database:BIOMD0000000477 [DatabaseIdentifier:12325446] BioModels Database:BIOMD0000000424 [DatabaseIdentifier:12325382] BioModels Database:BIOMD0000000654
dbId	5675221
displayName	Negative regulation of MAPK pathway
edited	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
eventOf	[Pathway:R-HSA-5673001] RAF/MAP kinase cascade - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5674140] PAQR3 binds inactive RAFs - Homo sapiens [Pathway:R-HSA-5674499] Negative feedback regulation of MAPK pathway - Homo sapiens [Reaction:R-HSA-5675417] PEBP1 binds activated RAF1 - Homo sapiens [Reaction:R-HSA-5675433] PP5 dephosphorylates RAF1 S338 - Homo sapiens [Reaction:R-HSA-5675431] PP2A dephosphorylates RAF1 - Homo sapiens [Reaction:R-HSA-5675376] Cytosolic DUSPs dephosphorylate MAPKs - Homo sapiens [Reaction:R-HSA-5675373] Nuclear DUSPs dephosphorylate MAPKs - Homo sapiens [Reaction:R-HSA-5674019] BRAP binds KSR1:MARK3 - Homo sapiens [Reaction:R-HSA-5674018] BRAP binds RAS:GTP - Homo sapiens [Reaction:R-HSA-5674022] BRAP autoubiquitinates - Homo sapiens [Reaction:R-HSA-9635743] PTPN7 binds p-T,Y-MAPK - Homo sapiens [Reaction:R-HSA-9635739] PTPN7 dephosphorylates p-T,Y-MAPKs - Homo sapiens [Reaction:R-HSA-8867654] PTPN3 binds p-T183,Y185 MAPK12 - Homo sapiens [Reaction:R-HSA-8867658] PTPN3 dephosphorylates MAPK12 - Homo sapiens [Reaction:R-HSA-8868118] MAPK12 phosphorylates PTPN3 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5675123] Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway [LiteratureReference:5672246] Raf family kinases: old dogs have learned new tricks [LiteratureReference:5675171] Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5 [LiteratureReference:5674456] Regulation of Raf-1 by direct feedback phosphorylation [LiteratureReference:5673933] A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal [LiteratureReference:5675142] Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases [LiteratureReference:5658234] Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis
modified	[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name	Negative regulation of MAPK pathway
orthologousEvent	[Pathway:R-MMU-5675221] Negative regulation of MAPK pathway - Mus musculus [Pathway:R-RNO-5675221] Negative regulation of MAPK pathway - Rattus norvegicus [Pathway:R-CFA-5675221] Negative regulation of MAPK pathway - Canis familiaris [Pathway:R-BTA-5675221] Negative regulation of MAPK pathway - Bos taurus [Pathway:R-SSC-5675221] Negative regulation of MAPK pathway - Sus scrofa [Pathway:R-DRE-5675221] Negative regulation of MAPK pathway - Danio rerio [Pathway:R-XTR-5675221] Negative regulation of MAPK pathway - Xenopus tropicalis [Pathway:R-GGA-5675221] Negative regulation of MAPK pathway - Gallus gallus [Pathway:R-DME-5675221] Negative regulation of MAPK pathway - Drosophila melanogaster [Pathway:R-CEL-5675221] Negative regulation of MAPK pathway - Caenorhabditis elegans [Pathway:R-DDI-5675221] Negative regulation of MAPK pathway - Dictyostelium discoideum [Pathway:R-SPO-5675221] Negative regulation of MAPK pathway - Schizosaccharomyces pombe [Pathway:R-SCE-5675221] Negative regulation of MAPK pathway - Saccharomyces cerevisiae [Pathway:R-PFA-5675221] Negative regulation of MAPK pathway - Plasmodium falciparum
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5675221
summation	[Summation:5675209] The duration and extent of activated MAPK signaling is regul...

Referrals

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[Pathway:R-HSA-5673001] RAF/MAP kinase cascade

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