Reactome | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants

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Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Show undefined attributes

authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:1236383] Orlic-Milacic, Marija, 2011-03-25
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992 [DatabaseIdentifier:12819465] BioModels Database:BIOMD0000000255 [DatabaseIdentifier:12819433] BioModels Database:BIOMD0000000653 [DatabaseIdentifier:12819435] BioModels Database:BIOMD0000000656 [DatabaseIdentifier:12819561] BioModels Database:BIOMD0000000594 [DatabaseIdentifier:12819437] BioModels Database:BIOMD0000000648 [DatabaseIdentifier:12819563] BioModels Database:BIOMD0000000223 [DatabaseIdentifier:12819471] BioModels Database:BIOMD0000000175 [DatabaseIdentifier:12819441] BioModels Database:BIOMD0000000655 [DatabaseIdentifier:12819565] BioModels Database:BIOMD0000000595 [DatabaseIdentifier:12819443] BioModels Database:BIOMD0000000652 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12819481] BioModels Database:BIOMD0000000399 [DatabaseIdentifier:12819483] BioModels Database:BIOMD0000000019 [DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477 [DatabaseIdentifier:12819445] BioModels Database:BIOMD0000000654
dbId	1236382
disease	[Disease:1500689] cancer
displayName	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07 [InstanceEdit:1990858] Jassal, B, 2011-11-07 [InstanceEdit:1990852] Gillespie, ME, 2011-11-07 [InstanceEdit:1990850] Haw, R, 2011-11-07
eventOf	[Pathway:R-HSA-5637815] Signaling by Ligand-Responsive EGFR Variants in Cancer - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-1218833] Binding of ligand-responsive EGFR mutants to chaperoning proteins HSP90 and CDC37 - Homo sapiens [Reaction:R-HSA-1220612] Binding of EGF to ligand-responsive EGFR mutants - Homo sapiens [Reaction:R-HSA-1220613] EGF-induced dimerization of ligand-responsive EGFR mutants - Homo sapiens [Reaction:R-HSA-1220614] Spontaneous dimerization of ligand-responsive EGFR mutants - Homo sapiens [Reaction:R-HSA-1169421] Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers - Homo sapiens [Reaction:R-HSA-1225950] Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants - Homo sapiens [Reaction:R-HSA-1225951] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants) - Homo sapiens [Reaction:R-HSA-1225947] Binding of SHC1 to p-6Y-EGFR mutants - Homo sapiens [Reaction:R-HSA-1225952] Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants - Homo sapiens [Reaction:R-HSA-1225961] Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex - Homo sapiens [Reaction:R-HSA-1225957] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) - Homo sapiens [Reaction:R-HSA-1226016] Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants - Homo sapiens [Reaction:R-HSA-1226012] Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants - Homo sapiens [Reaction:R-HSA-1226014] Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants - Homo sapiens [Reaction:R-HSA-1247841] PLCG1 binds to ligand-responsive p-6Y-EGFR mutants - Homo sapiens [Reaction:R-HSA-1247844] Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants - Homo sapiens [Reaction:R-HSA-1247842] Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants - Homo sapiens [Reaction:R-HSA-1225949] Binding of CBL to ligand-responsive p-6Y-EGFR mutants - Homo sapiens [Reaction:R-HSA-1225960] Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants - Homo sapiens [FailedReaction:R-HSA-1225956] Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL - Homo sapiens [Reaction:R-HSA-1218824] HSP90 is inactivated by binding to benzaquinoid ansamycins - Homo sapiens [Reaction:R-HSA-1220610] Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants - Homo sapiens [Reaction:R-HSA-1220611] Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2023-06-07
maxDepth	2
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1236382
summation	[Summation:1181246] Signaling by EGFR is frequently activated in cancer through ...
updateTrackers	[UpdateTracker:9775574] Update Tracker - [Pathway:1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - v78:[updateContainedRLE] [UpdateTracker:9785258] Update Tracker - [Pathway:1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - v52:[updateContainedRLE] [UpdateTracker:9788737] Update Tracker - [Pathway:1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - v40:[modifyText] [UpdateTracker:9835740] Update Tracker - [Pathway:1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - v85:[updateContainedRLE] [UpdateTracker:9777976] Update Tracker - [Pathway:1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - v68:[updateContainedRLE] [UpdateTracker:9785810] Update Tracker - [Pathway:1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - v51:[modifyText, removeHasEvent, updateContainedRLE] [UpdateTracker:9846732] Update Tracker - [Pathway:1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - v84:[updateContainedRLE] [UpdateTracker:9779777] Update Tracker - [Pathway:1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - v64:[updateContainedRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-5637815] Signaling by Ligand-Responsive EGFR Variants in Cancer

(updatedInstance)

[UpdateTracker:9775574] Update Tracker - [Pathway:1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - v78:[updateContainedRLE]
[UpdateTracker:9785258] Update Tracker - [Pathway:1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - v52:[updateContainedRLE]
[UpdateTracker:9788737] Update Tracker - [Pathway:1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - v40:[modifyText]
[UpdateTracker:9835740] Update Tracker - [Pathway:1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - v85:[updateContainedRLE]
[UpdateTracker:9777976] Update Tracker - [Pathway:1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - v68:[updateContainedRLE]
[UpdateTracker:9785810] Update Tracker - [Pathway:1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - v51:[modifyText, removeHasEvent, updateContainedRLE]
[UpdateTracker:9846732] Update Tracker - [Pathway:1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - v84:[updateContainedRLE]
[UpdateTracker:9779777] Update Tracker - [Pathway:1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - v64:[updateContainedRLE]

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