Reactome | Negative feedback regulation of MAPK pathway

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Negative feedback regulation of MAPK pathway Show undefined attributes

authored	[InstanceEdit:5674393] Rothfels, Karen, 2015-02-11
created	[InstanceEdit:5674498] Rothfels, Karen, 2015-02-12
crossReference	[DatabaseIdentifier:12819513] BioModels Database:BIOMD0000000251 [DatabaseIdentifier:12819501] BioModels Database:BIOMD0000000427 [DatabaseIdentifier:12819465] BioModels Database:BIOMD0000000255 [DatabaseIdentifier:12819433] BioModels Database:BIOMD0000000653 [DatabaseIdentifier:12819435] BioModels Database:BIOMD0000000656 [DatabaseIdentifier:12819503] BioModels Database:BIOMD0000000832 [DatabaseIdentifier:12819473] BioModels Database:BIOMD0000000659 [DatabaseIdentifier:12819475] BioModels Database:BIOMD0000000149 [DatabaseIdentifier:12819505] BioModels Database:BIOMD0000000557 [DatabaseIdentifier:12819429] BioModels Database:BIOMD0000000664 [DatabaseIdentifier:12819477] BioModels Database:BIOMD0000000651 [DatabaseIdentifier:12819437] BioModels Database:BIOMD0000000648 [DatabaseIdentifier:12819471] BioModels Database:BIOMD0000000175 [DatabaseIdentifier:12819441] BioModels Database:BIOMD0000000655 [DatabaseIdentifier:12819479] BioModels Database:BIOMD0000000288 [DatabaseIdentifier:12819443] BioModels Database:BIOMD0000000652 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12819481] BioModels Database:BIOMD0000000399 [DatabaseIdentifier:12819483] BioModels Database:BIOMD0000000019 [DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477 [DatabaseIdentifier:12819485] BioModels Database:BIOMD0000000424 [DatabaseIdentifier:12819445] BioModels Database:BIOMD0000000654
dbId	5674499
displayName	Negative feedback regulation of MAPK pathway
edited	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
eventOf	[Pathway:R-HSA-5675221] Negative regulation of MAPK pathway - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5674496] Activated MAPKs phosphorylate MAP2K1 - Homo sapiens [Reaction:R-HSA-5675194] Activated MAPK phosphorylates RAF1 - Homo sapiens [Reaction:R-HSA-5675198] Activated MAPKs phosphorylate BRAF - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5674446] Downregulation of the Ras activation pathway by MAP kinase phosphorylation of Sos [LiteratureReference:5674462] SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways [LiteratureReference:5674456] Regulation of Raf-1 by direct feedback phosphorylation [LiteratureReference:5674485] The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier [LiteratureReference:5674471] Strong negative feedback from Erk to Raf confers robustness to MAPK signalling [LiteratureReference:5672524] Regulation and role of Raf-1/B-Raf heterodimerization [LiteratureReference:5674449] Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf [LiteratureReference:5672454] Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling [LiteratureReference:5673933] A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Negative feedback regulation of MAPK pathway
orthologousEvent	[Pathway:R-MMU-5674499] Negative feedback regulation of MAPK pathway - Mus musculus [Pathway:R-RNO-5674499] Negative feedback regulation of MAPK pathway - Rattus norvegicus [Pathway:R-CFA-5674499] Negative feedback regulation of MAPK pathway - Canis familiaris [Pathway:R-BTA-5674499] Negative feedback regulation of MAPK pathway - Bos taurus [Pathway:R-SSC-5674499] Negative feedback regulation of MAPK pathway - Sus scrofa [Pathway:R-DRE-5674499] Negative feedback regulation of MAPK pathway - Danio rerio [Pathway:R-XTR-5674499] Negative feedback regulation of MAPK pathway - Xenopus tropicalis [Pathway:R-GGA-5674499] Negative feedback regulation of MAPK pathway - Gallus gallus [Pathway:R-DME-5674499] Negative feedback regulation of MAPK pathway - Drosophila melanogaster [Pathway:R-CEL-5674499] Negative feedback regulation of MAPK pathway - Caenorhabditis elegans [Pathway:R-DDI-5674499] Negative feedback regulation of MAPK pathway - Dictyostelium discoideum
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5674499
summation	[Summation:5674497] MAPK pathway activation is limited by a number of negative f...

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[Pathway:R-HSA-5675221] Negative regulation of MAPK pathway

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