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Entries
Signaling by high-kinase activity BRAF mutants
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authored
[InstanceEdit:6802811] Rothfels, Karen, 2015-08-10
created
[InstanceEdit:6802947] Rothfels, Karen, 2015-10-02
crossReference
[DatabaseIdentifier:12325482] BioModels Database:BIOMD0000000251
[DatabaseIdentifier:12325470] BioModels Database:BIOMD0000000427
[DatabaseIdentifier:12325424] BioModels Database:BIOMD0000000255
[DatabaseIdentifier:12325370] BioModels Database:BIOMD0000000653
[DatabaseIdentifier:12325372] BioModels Database:BIOMD0000000656
[DatabaseIdentifier:12325472] BioModels Database:BIOMD0000000832
[DatabaseIdentifier:12325434] BioModels Database:BIOMD0000000659
[DatabaseIdentifier:12325386] BioModels Database:BIOMD0000000338
[DatabaseIdentifier:12325388] BioModels Database:BIOMD0000000340
[DatabaseIdentifier:12325436] BioModels Database:BIOMD0000000149
[DatabaseIdentifier:12325474] BioModels Database:BIOMD0000000557
[DatabaseIdentifier:12325592] BioModels Database:BIOMD0000000842
[DatabaseIdentifier:12325344] BioModels Database:BIOMD0000000664
[DatabaseIdentifier:12325438] BioModels Database:BIOMD0000000651
[DatabaseIdentifier:12325374] BioModels Database:BIOMD0000000648
[DatabaseIdentifier:12325476] BioModels Database:BIOMD0000000466
[DatabaseIdentifier:12325430] BioModels Database:BIOMD0000000175
[DatabaseIdentifier:12325378] BioModels Database:BIOMD0000000655
[DatabaseIdentifier:12325440] BioModels Database:BIOMD0000000288
[DatabaseIdentifier:12325380] BioModels Database:BIOMD0000000652
[DatabaseIdentifier:12325478] BioModels Database:BIOMD0000000069
[DatabaseIdentifier:12325398] BioModels Database:BIOMD0000000339
[DatabaseIdentifier:12325346] BioModels Database:BIOMD0000000883
[DatabaseIdentifier:12325480] BioModels Database:BIOMD0000000468
[DatabaseIdentifier:12325442] BioModels Database:BIOMD0000000399
[DatabaseIdentifier:12325444] BioModels Database:BIOMD0000000019
[DatabaseIdentifier:12325404] BioModels Database:BIOMD0000000477
[DatabaseIdentifier:12325446] BioModels Database:BIOMD0000000424
[DatabaseIdentifier:12325382] BioModels Database:BIOMD0000000654
dbId
6802948
disease
[Disease:1500689] cancer
displayName
Signaling by high-kinase activity BRAF mutants
edited
[InstanceEdit:6802811] Rothfels, Karen, 2015-08-10
eventOf
[Pathway:R-HSA-6802957] Oncogenic MAPK signaling - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-6802912] High kinase activity BRAF mutants bind MAP2Ks and MAPKs - Homo sapiens
[Reaction:R-HSA-6802911] High kinase activity BRAF complexes phosphorylate MAP2Ks - Homo sapiens
[Reaction:R-HSA-6802910] Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants - Homo sapiens
[Reaction:R-HSA-6803227] Dissociation of high activity BRAF complexes - Homo sapiens
[Reaction:R-HSA-6802938] Inhibitors bind and inhibit highly active BRAF mutants - Homo sapiens
[Reaction:R-HSA-6802930] Dimerization of BRAF V600E splice variants contributes to BRAF inhibitor resistance - Homo sapiens
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:5672236] Mutations of the BRAF gene in human cancer
[LiteratureReference:6790420] Targeting RAS-ERK signalling in cancer: promises and challenges
[LiteratureReference:5672469] Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
[LiteratureReference:6790338] Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma
[LiteratureReference:6790314] Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling
[LiteratureReference:6790328] Functional analysis of the regulatory requirements of B-Raf and the B-Raf(V600E) oncoprotein
[LiteratureReference:6790322] Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling
[LiteratureReference:5672291] Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization
[LiteratureReference:6799060] RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
[LiteratureReference:6790435] Tumor adaptation and resistance to RAF inhibitors
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
Signaling by high-kinase activity BRAF mutants
normalPathway
[Pathway:R-HSA-5673001] RAF/MAP kinase cascade
releaseDate
2016-09-19
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8933498] Stephens, Robert M, 2016-08-05
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-6802948
summation
[Summation:6802187] BRAF is mutated in about 8% of human cancers, with high prev...
Referrals
(hasEvent)
[Pathway:R-HSA-6802957] Oncogenic MAPK signaling
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