Reactome | SHC1 events in ERBB2 signaling

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SHC1 events in ERBB2 signaling Show undefined attributes

authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1250197] Orlic-Milacic, Marija, 2011-04-14
crossReference	[DatabaseIdentifier:12819465] BioModels Database:BIOMD0000000255 [DatabaseIdentifier:12819433] BioModels Database:BIOMD0000000653 [DatabaseIdentifier:12819435] BioModels Database:BIOMD0000000656 [DatabaseIdentifier:12819561] BioModels Database:BIOMD0000000594 [DatabaseIdentifier:12819437] BioModels Database:BIOMD0000000648 [DatabaseIdentifier:12819507] BioModels Database:BIOMD0000000466 [DatabaseIdentifier:12819449] BioModels Database:BIOMD0000000940 [DatabaseIdentifier:12819563] BioModels Database:BIOMD0000000223 [DatabaseIdentifier:12819471] BioModels Database:BIOMD0000000175 [DatabaseIdentifier:12819441] BioModels Database:BIOMD0000000655 [DatabaseIdentifier:12819565] BioModels Database:BIOMD0000000595 [DatabaseIdentifier:12819443] BioModels Database:BIOMD0000000652 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12819511] BioModels Database:BIOMD0000000468 [DatabaseIdentifier:12819481] BioModels Database:BIOMD0000000399 [DatabaseIdentifier:12819483] BioModels Database:BIOMD0000000019 [DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477 [DatabaseIdentifier:12819485] BioModels Database:BIOMD0000000424 [DatabaseIdentifier:12819445] BioModels Database:BIOMD0000000654
dbId	1250196
displayName	SHC1 events in ERBB2 signaling
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1972360] D'Eustachio, P, 2011-11-07
eventOf	[Pathway:R-HSA-1227986] Signaling by ERBB2 - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-1963578] SHC1 binds phosphorylated ERBB2 heterodimers - Homo sapiens [Reaction:R-HSA-1250195] SHC1 phosphorylation by ERBB2 heterodimers - Homo sapiens [Reaction:R-HSA-1250486] Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers - Homo sapiens [Reaction:R-HSA-1250463] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers - Homo sapiens [Reaction:R-HSA-8934446] Activated PKC phosphorylates SHC1 - Homo sapiens [Reaction:R-HSA-8934465] SHC1 binds PTPN12 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-09-09
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	SHC1 events in ERBB2 signaling
orthologousEvent	[Pathway:R-MMU-1250196] SHC1 events in ERBB2 signaling - Mus musculus [Pathway:R-RNO-1250196] SHC1 events in ERBB2 signaling - Rattus norvegicus [Pathway:R-CFA-1250196] SHC1 events in ERBB2 signaling - Canis familiaris [Pathway:R-BTA-1250196] SHC1 events in ERBB2 signaling - Bos taurus [Pathway:R-SSC-1250196] SHC1 events in ERBB2 signaling - Sus scrofa [Pathway:R-DRE-1250196] SHC1 events in ERBB2 signaling - Danio rerio [Pathway:R-XTR-1250196] SHC1 events in ERBB2 signaling - Xenopus tropicalis [Pathway:R-GGA-1250196] SHC1 events in ERBB2 signaling - Gallus gallus [Pathway:R-DME-1250196] SHC1 events in ERBB2 signaling - Drosophila melanogaster [Pathway:R-CEL-1250196] SHC1 events in ERBB2 signaling - Caenorhabditis elegans
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1972347] Neckers, LM, 2011-11-11 [InstanceEdit:1972346] Xu, W, 2011-11-11
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1250196
summation	[Summation:1361852] All ERBB2 heterodimers, ERBB2:EGFR, ERBB2:ERBB3 and ERBB2:ER...
updateTrackers	[UpdateTracker:9777519] Update Tracker - [Pathway:1250196] SHC1 events in ERBB2 signaling - v70:[updateContainedRLE] [UpdateTracker:9783737] Update Tracker - [Pathway:1250196] SHC1 events in ERBB2 signaling - v56:[removeHasEvent] [UpdateTracker:9784786] Update Tracker - [Pathway:1250196] SHC1 events in ERBB2 signaling - v53:[add_removeHasEvent] [UpdateTracker:9782991] Update Tracker - [Pathway:1250196] SHC1 events in ERBB2 signaling - v58:[addHasEvent] [UpdateTracker:9783135] Update Tracker - [Pathway:1250196] SHC1 events in ERBB2 signaling - v57:[updateContainedRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-1227986] Signaling by ERBB2

(updatedInstance)

[UpdateTracker:9777519] Update Tracker - [Pathway:1250196] SHC1 events in ERBB2 signaling - v70:[updateContainedRLE]
[UpdateTracker:9783737] Update Tracker - [Pathway:1250196] SHC1 events in ERBB2 signaling - v56:[removeHasEvent]
[UpdateTracker:9784786] Update Tracker - [Pathway:1250196] SHC1 events in ERBB2 signaling - v53:[add_removeHasEvent]
[UpdateTracker:9782991] Update Tracker - [Pathway:1250196] SHC1 events in ERBB2 signaling - v58:[addHasEvent]
[UpdateTracker:9783135] Update Tracker - [Pathway:1250196] SHC1 events in ERBB2 signaling - v57:[updateContainedRLE]

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