Reactome | Signaling downstream of RAS mutants

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Signaling downstream of RAS mutants Show undefined attributes

authored	[InstanceEdit:5693873] Rothfels, Karen, 2015-05-18
created	[InstanceEdit:9649947] Rothfels, Karen, 2019-06-19
crossReference	[DatabaseIdentifier:12819497] BioModels Database:BIOMD0000000467 [DatabaseIdentifier:12020745] Mondo:0004992 [DatabaseIdentifier:12819501] BioModels Database:BIOMD0000000427 [DatabaseIdentifier:12819465] BioModels Database:BIOMD0000000255 [DatabaseIdentifier:12819433] BioModels Database:BIOMD0000000653 [DatabaseIdentifier:12819435] BioModels Database:BIOMD0000000656 [DatabaseIdentifier:12819503] BioModels Database:BIOMD0000000832 [DatabaseIdentifier:12819473] BioModels Database:BIOMD0000000659 [DatabaseIdentifier:12819475] BioModels Database:BIOMD0000000149 [DatabaseIdentifier:12819505] BioModels Database:BIOMD0000000557 [DatabaseIdentifier:12819429] BioModels Database:BIOMD0000000664 [DatabaseIdentifier:12819477] BioModels Database:BIOMD0000000651 [DatabaseIdentifier:12819437] BioModels Database:BIOMD0000000648 [DatabaseIdentifier:12819507] BioModels Database:BIOMD0000000466 [DatabaseIdentifier:12819471] BioModels Database:BIOMD0000000175 [DatabaseIdentifier:12819441] BioModels Database:BIOMD0000000655 [DatabaseIdentifier:12819479] BioModels Database:BIOMD0000000288 [DatabaseIdentifier:12819443] BioModels Database:BIOMD0000000652 [DatabaseIdentifier:12819509] BioModels Database:BIOMD0000000069 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12819511] BioModels Database:BIOMD0000000468 [DatabaseIdentifier:12819481] BioModels Database:BIOMD0000000399 [DatabaseIdentifier:12819483] BioModels Database:BIOMD0000000019 [DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477 [DatabaseIdentifier:12819485] BioModels Database:BIOMD0000000424 [DatabaseIdentifier:12819445] BioModels Database:BIOMD0000000654
dbId	9649948
disease	[Disease:1500689] cancer
displayName	Signaling downstream of RAS mutants
eventOf	[Pathway:R-HSA-6802949] Signaling by RAS mutants - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-6802908] RAS mutants bind inactive RAF - Homo sapiens [BlackBoxEvent:R-HSA-6803240] Homo- or heterodimerization of RAF downstream of mutant RAS - Homo sapiens [Reaction:R-HSA-6802924] RAF is phosphorylated downstream of oncogenic RAS - Homo sapiens [Reaction:R-HSA-6802925] Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs - Homo sapiens [Reaction:R-HSA-6802926] Mutant RAS:p-RAF complexes phosphorylate MAP2Ks - Homo sapiens [Reaction:R-HSA-6802922] Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS - Homo sapiens [Reaction:R-HSA-6803233] Dissociation of oncogenic RAS:RAF complex - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:6790227] A comprehensive survey of Ras mutations in cancer [LiteratureReference:5658403] An expanding role for RAS GTPase activating proteins (RAS GAPs) in cancer [LiteratureReference:6799045] Dragging ras back in the ring [LiteratureReference:6790393] RAS oncogenes: weaving a tumorigenic web
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Signaling downstream of RAS mutants
normalPathway	[Pathway:R-HSA-5673001] RAF/MAP kinase cascade
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933498] Stephens, Robert M, 2016-08-05
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9649948
summation	[Summation:9651077] Disease-causing mutations in RAS favour the active RAS:GTP b...

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[Pathway:R-HSA-6802949] Signaling by RAS mutants

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