Reactome | GAB1 signalosome

Schema > Pathway > Entries

GAB1 signalosome Show undefined attributes

authored	[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
created	[InstanceEdit:180315] Jassal, B, 2006-05-18 13:16:38
crossReference	[DatabaseIdentifier:12819465] BioModels Database:BIOMD0000000255 [DatabaseIdentifier:12819433] BioModels Database:BIOMD0000000653 [DatabaseIdentifier:12819435] BioModels Database:BIOMD0000000656 [DatabaseIdentifier:12819561] BioModels Database:BIOMD0000000594 [DatabaseIdentifier:12819469] BioModels Database:BIOMD0000000724 [DatabaseIdentifier:12819437] BioModels Database:BIOMD0000000648 [DatabaseIdentifier:12819507] BioModels Database:BIOMD0000000466 [DatabaseIdentifier:12819563] BioModels Database:BIOMD0000000223 [DatabaseIdentifier:12819471] BioModels Database:BIOMD0000000175 [DatabaseIdentifier:12819441] BioModels Database:BIOMD0000000655 [DatabaseIdentifier:12819565] BioModels Database:BIOMD0000000595 [DatabaseIdentifier:12819443] BioModels Database:BIOMD0000000652 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12819511] BioModels Database:BIOMD0000000468 [DatabaseIdentifier:12819481] BioModels Database:BIOMD0000000399 [DatabaseIdentifier:12819483] BioModels Database:BIOMD0000000019 [DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477 [DatabaseIdentifier:12819445] BioModels Database:BIOMD0000000654
dbId	180292
displayName	GAB1 signalosome
doi	10.3180/REACT_12578.1
eventOf	[Pathway:R-HSA-177929] Signaling by EGFR - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-177920] Binding of GRB2 to GAB1 - Homo sapiens [Reaction:R-HSA-177941] GRB2:GAB1 binds to phosphorylated EGFR - Homo sapiens [Reaction:R-HSA-179467] GAB1 binds phosphatidylinositol-3,4,5-trisphosphate - Homo sapiens [Reaction:R-HSA-177930] GAB1 phosphorylation by EGFR kinase - Homo sapiens [Reaction:R-HSA-177927] PI3K binds to EGF:EGFR:GRB2:GAB1 - Homo sapiens [Reaction:R-HSA-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) - Homo sapiens [Reaction:R-HSA-177944] Activation of SHP2 through the binding to phospho-Gab1 - Homo sapiens [Reaction:R-HSA-177924] Dephosphorylation of Gab1 by SHP2 - Homo sapiens [Reaction:R-HSA-177935] SHP2 dephosphorylates Tyr 992 on EGFR - Homo sapiens [Reaction:R-HSA-177926] Dephosphorylation of PAG by SHP2 - Homo sapiens [Reaction:R-HSA-177923] Sustained activation of SRC kinase by SHP2 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-12-13
literatureReference	[LiteratureReference:188658] The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	GAB1 signalosome
orthologousEvent	[Pathway:R-MMU-180292] GAB1 signalosome - Mus musculus [Pathway:R-CFA-180292] GAB1 signalosome - Canis familiaris [Pathway:R-BTA-180292] GAB1 signalosome - Bos taurus [Pathway:R-SSC-180292] GAB1 signalosome - Sus scrofa [Pathway:R-DRE-180292] GAB1 signalosome - Danio rerio [Pathway:R-XTR-180292] GAB1 signalosome - Xenopus tropicalis [Pathway:R-GGA-180292] GAB1 signalosome - Gallus gallus [Pathway:R-DME-180292] GAB1 signalosome - Drosophila melanogaster [Pathway:R-CEL-180292] GAB1 signalosome - Caenorhabditis elegans [Pathway:R-RNO-180292] GAB1 signalosome - Rattus norvegicus
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-180292
summation	[Summation:188602] GAB1 is recruited to the activated EGFR indirectly, through ...
updateTrackers	[UpdateTracker:9778796] Update Tracker - [Pathway:180292] GAB1 signalosome - v67:[updateContainedRLE] [UpdateTracker:9784459] Update Tracker - [Pathway:180292] GAB1 signalosome - v54:[updateIndirectRLE] [UpdateTracker:9782696] Update Tracker - [Pathway:180292] GAB1 signalosome - v59:[updateIndirectRLE] [UpdateTracker:9779807] Update Tracker - [Pathway:180292] GAB1 signalosome - v64:[removeHasEvent, updateContainedRLE] [UpdateTracker:9853197] Update Tracker - [Pathway:180292] GAB1 signalosome - v87:[updateContainedRLE] [UpdateTracker:9788368] Update Tracker - [Pathway:180292] GAB1 signalosome - v42:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9780829] Update Tracker - [Pathway:180292] GAB1 signalosome - v62:[removeHasEvent] [UpdateTracker:9789167] Update Tracker - [Pathway:180292] GAB1 signalosome - v38:[addHasEvent, modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9782765] Update Tracker - [Pathway:180292] GAB1 signalosome - v58:[updateContainedPathway] [UpdateTracker:9781497] Update Tracker - [Pathway:180292] GAB1 signalosome - v61:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9783710] Update Tracker - [Pathway:180292] GAB1 signalosome - v56:[updateContainedPathway] [UpdateTracker:9783884] Update Tracker - [Pathway:180292] GAB1 signalosome - v55:[updateIndirectRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-177929] Signaling by EGFR

(updatedInstance)

Cite Us!