Reactome | CTNNB1 T41 mutants aren't phosphorylated

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CTNNB1 T41 mutants aren't phosphorylated Show undefined attributes

authored	[InstanceEdit:5358711] Rothfels, Karen, 2014-04-02
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5358753] Rothfels, Karen, 2014-04-03
crossReference	[DatabaseIdentifier:12819433] BioModels Database:BIOMD0000000653 [DatabaseIdentifier:12020745] Mondo:0004992 [DatabaseIdentifier:12819435] BioModels Database:BIOMD0000000656 [DatabaseIdentifier:12819475] BioModels Database:BIOMD0000000149 [DatabaseIdentifier:12819437] BioModels Database:BIOMD0000000648 [DatabaseIdentifier:12819439] BioModels Database:BIOMD0000000657 [DatabaseIdentifier:12819441] BioModels Database:BIOMD0000000655 [DatabaseIdentifier:12819443] BioModels Database:BIOMD0000000652 [DatabaseIdentifier:12819445] BioModels Database:BIOMD0000000654
dbId	5358752
disease	[Disease:1500689] cancer
displayName	CTNNB1 T41 mutants aren't phosphorylated
edited	[InstanceEdit:5358774] Matthews, Lisa, 2014-04-03
eventOf	[Pathway:R-HSA-4839743] Signaling by CTNNB1 phospho-site mutants - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[FailedReaction:R-HSA-4839638] CTNNB1 T41 mutants aren't phosphorylated by GSK3beta - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2015-03-23
literatureReference	[LiteratureReference:5251472] Abnormalities of the APC/beta-catenin pathway in endometrial cancer [LiteratureReference:5251510] Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas [LiteratureReference:5246618] Wnt signaling and cancer [LiteratureReference:5246620] Wnt signaling in cancer [LiteratureReference:3238089] The way Wnt works: Components and mechanism
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	CTNNB1 T41 mutants aren't phosphorylated
normalPathway	[Pathway:R-HSA-195253] Degradation of beta-catenin by the destruction complex
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5433076] Salahshor, S, 2014-05-12 [InstanceEdit:5545509] Woodgett, Jim, 2014-05-21
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5358752
summation	[Summation:5255467] T41 mutations of beta-catenin interfere with GSK3 phosphoryl...
updateTrackers	[UpdateTracker:9785066] Update Tracker - [Pathway:5358752] CTNNB1 T41 mutants aren't phosphorylated - v52:[removeHasEvent]

Referrals

(updatedInstance)	[UpdateTracker:9785066] Update Tracker - [Pathway:5358752] CTNNB1 T41 mutants aren't phosphorylated - v52:[removeHasEvent]
(hasEvent)	[Pathway:R-HSA-4839743] Signaling by CTNNB1 phospho-site mutants