Reactome | Ub-215-UBB(153-228) [nucleoplasm]

Ub-215-UBB(153-228) [nucleoplasm]

Stable Identifier

R-HSA-6782475

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

K63 ubiquitin (UBB 3)

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- Nucleotide Excision Repair (Homo sapiens)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
    - Formation of Incision Complex in GG-NER (Homo sapiens)
      - RNF111 ubiquitinates SUMOylated XPC (Homo sapiens)
        
        K63polyUb:C87-UBE2N:UBE2V2 [nucleoplasm] (Homo sapiens)
        
        K63polyUb:C87-UBE2N [nucleoplasm] (Homo sapiens)
        
        K63-Ub [nucleoplasm] (Homo sapiens)
        
        Ub-215-UBB(153-228) [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO,K63polyUb:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO,K63polyUb:XPC [nucleoplasm] (Homo sapiens)
        
        K63-Ub [nucleoplasm] (Homo sapiens)
        
        Ub-215-UBB(153-228) [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        USP2 deubiquitinates MDM2,MDM4 (Homo sapiens)
        
        PolyUb [nucleoplasm] (Homo sapiens)
        
        K63polyUb [nucleoplasm] (Homo sapiens)
        
        K63-Ub [nucleoplasm] (Homo sapiens)
        
        Ub-215-UBB(153-228) [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P0CG47 UBB

Gene Names

UBB

Chain

chain:1-76, chain:77-152, chain:153-228, propeptide:-

Reference Genes

BioGPS Gene:7314 UBB

COSMIC (genes):UBB UBB

CTD Gene:7314 UBB

dbSNP Gene:7314 UBB

ENSEMBL:ENSG00000170315 UBB

ENSEMBL:ENSG00000170315.14 UBB

HGNC:12463 UBB

KEGG Gene (Homo sapiens):7314 UBB

Monarch:7314 UBB

NCBI Gene:7314 UBB

OMIM:191339 UBB

Reference Transcript

Other Identifiers

11732126_x_at

11744327_x_at

1323_at

16831434

200633_PM_at

200633_at

2578171

2578172

2578173

2578174

32153_s_at

3712045

3712046

3712047

3712048

3712050

3712051

3712052

3712053

3712054

3712055

3712056

3714880

3714882

3714883

3714884

3714885

3714889

7314

8005166

A_14_P126655

A_23_P27215

A_24_P113109

GE79998

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005741

GO:0005768

GO:0005783

GO:0005789

GO:0005829

GO:0005886

GO:0007018

GO:0007141

GO:0007144

GO:0008584

GO:0008585

GO:0010008

GO:0012501

GO:0016020

GO:0016567

GO:0019941

GO:0021888

GO:0022414

GO:0023052

GO:0030154

GO:0030163

GO:0030666

GO:0031386

GO:0031398

GO:0031410

GO:0031625

GO:0031982

GO:0036211

GO:0043005

GO:0043025

GO:0043226

GO:0043523

GO:0047497

GO:0048812

GO:0048856

GO:0051881

GO:0060612

GO:0060613

GO:0061136

GO:0070062

GO:0072520

GO:0097009

GO:0140013

GO:1902255

GO:1902527

HMNXSV003053727

ILMN_1762436

ILMN_2191428

PH_hs_0017263

TC17000187.hg

U49869_rna1_at

g11024713_3p_at

Participates

as a member of

K63-Ub [nucleoplasm] (Homo sapiens)

Other forms of this molecule

UBB(77-152) [endocytic vesicle membrane]

UBB(1-76) [endocytic vesicle membrane]

UBB(153-228) [endocytic vesicle membrane]

Ub-33-UBB(1-76) [mitochondrial outer membrane]

Ub-109-UBB(77-152) [mitochondrial outer membrane]

Ub-185-UBB(153-228) [mitochondrial outer membrane]

Ub-215-UBB(153-228) [mitochondrial outer membrane]

Ub-63-UBB(1-76) [mitochondrial outer membrane]

Ub-139-UBB(77-152) [mitochondrial outer membrane]

Ub-158-UBB(153-228) [mitochondrial outer membrane]

Ub-6-UBB(1-76) [mitochondrial outer membrane]

Ub-82-UBB(77-152) [mitochondrial outer membrane]

Ub-163-UBB(153-228) [mitochondrial outer membrane]

Ub-87-UBB(77-152) [mitochondrial outer membrane]

Ub-11-UBB(1-76) [mitochondrial outer membrane]

Ub-124-UBB(77-152) [mitochondrial outer membrane]

Ub-200-UBB(153-228) [mitochondrial outer membrane]

Ub-48-UBB(1-76) [mitochondrial outer membrane]

Ub-181-UBB(153-228) [mitochondrial outer membrane]

Ub-29-UBB(1-76) [mitochondrial outer membrane]

Ub-105-UBB(77-152) [mitochondrial outer membrane]

Ub-27-UBB(1-76) [mitochondrial outer membrane]

Ub-179-UBB(153-228) [mitochondrial outer membrane]

Ub-103-UBB(77-152) [mitochondrial outer membrane]

N6-glycyl-L-lysine-UBB(1-76) [cytosol]

N6-glycyl-L-lysine-UBB(153-228) [cytosol]

N6-glycyl-L-lysine-UBB(77-152) [cytosol]

adenylatedG152-UBB(77-152) [nucleoplasm]

adenylatedG228-UBB(153-228) [nucleoplasm]

adenylatedG76-UBB(1-76) [nucleoplasm]

UBB [cytosol]

adenylatedG76-UBB(1-76) [cytosol]

adenylatedG228-UBB(153-228) [cytosol]

adenylatedG152-UBB(77-152) [cytosol]

Ub-124-UBB(77-152) [endoplasmic reticulum membrane]

Ub-48-UBB(1-76) [endoplasmic reticulum membrane]

Ub-200-UBB(153-228) [endoplasmic reticulum membrane]

Ub-48-UBB(1-76) [lysosomal membrane]

Ub-124-UBB(77-152) [lysosomal membrane]

Ub-200-UBB(153-228) [lysosomal membrane]

Ub-48-UBB(1-76) [endocytic vesicle membrane]

Ub-200-UBB(153-228) [endocytic vesicle membrane]

Ub-124-UBB(77-152) [endocytic vesicle membrane]

UBB(77-152) [endosome membrane]

UBB(1-76) [endosome membrane]

UBB(153-228) [endosome membrane]

UBB(153-228) [plasma membrane]

UBB(1-76) [plasma membrane]

UBB(77-152) [plasma membrane]

Ub-105-UBB(77-152) [cytosol]

Ub-181-UBB(153-228) [cytosol]

Ub-29-UBB(1-76) [cytosol]

Ub-158-UBB(153-228) [cytosol]

Ub-82-UBB(77-152) [cytosol]

Ub-6-UBB(1-76) [cytosol]

Ub-33-UBB(1-76) [cytosol]

Ub-185-UBB(153-228) [cytosol]

Ub-109-UBB(77-152) [cytosol]

Ub-27-UBB(1-76) [cytosol]

Ub-103-UBB(77-152) [cytosol]

Ub-179-UBB(153-228) [cytosol]

M1-UBB(153-228) [cytosol]

M1-UBB(1-76) [cytosol]

M1-UBB(77-152) [cytosol]

UBB(153-228) [endoplasmic reticulum membrane]

UBB(77-152) [endoplasmic reticulum membrane]

UBB(1-76) [endoplasmic reticulum membrane]

Ub-27-UBB(1-76) [nucleoplasm]

Ub-179-UBB(153-228) [nucleoplasm]

Ub-103-UBB(77-152) [nucleoplasm]

Ub-105-UBB(77-152) [nucleoplasm]

Ub-181-UBB(153-228) [nucleoplasm]

Ub-29-UBB(1-76) [nucleoplasm]

Ub-185-UBB(153-228) [nucleoplasm]

Ub-109-UBB(77-152) [nucleoplasm]

Ub-33-UBB(1-76) [nucleoplasm]

Ub-11-UBB(1-76) [nucleoplasm]

Ub-87-UBB(77-152) [nucleoplasm]

Ub-163-UBB(153-228) [nucleoplasm]

Ub-139-UBB(77-152) [endosome membrane]

Ub-215-UBB(153-228) [endosome membrane]

Ub-63-UBB(1-76) [endosome membrane]

Ub-139-UBB(77-152) [plasma membrane]

Ub-63-UBB(1-76) [plasma membrane]

Ub-215-UBB(153-228) [plasma membrane]

Ub-11-UBB(1-76) [cytosol]

Ub-163-UBB(153-228) [cytosol]

Ub-87-UBB(77-152) [cytosol]

Ub-48-UBB(1-76) [nucleoplasm]

Ub-124-UBB(77-152) [nucleoplasm]

Ub-200-UBB(153-228) [nucleoplasm]

UBB(77-152) [nucleoplasm]

UBB(1-76) [nucleoplasm]

UBB(153-228) [nucleoplasm]

Ub-139-UBB(77-152) [nucleoplasm]

Ub-63-UBB(1-76) [nucleoplasm]

Ub-82-UBB(77-152) [nucleoplasm]

Ub-6-UBB(1-76) [nucleoplasm]

Ub-158-UBB(153-228) [nucleoplasm]

UBB(153-228) [late endosome lumen]

UBB(77-152) [late endosome lumen]

UBB(1-76) [late endosome lumen]

Ub-48-UBB(1-76) [cytosol]

Ub-124-UBB(77-152) [cytosol]

Ub-200-UBB(153-228) [cytosol]

UBB(153-228) [cytosol]

UBB(77-152) [cytosol]

UBB(1-76) [cytosol]

UBB(77-152) [lysosomal lumen]

UBB(1-76) [lysosomal lumen]

UBB(153-228) [lysosomal lumen]

Ub-63-UBB(1-76) [cytosol]

Ub-215-UBB(153-228) [cytosol]

Ub-139-UBB(77-152) [cytosol]

Inferred To

ubc [nucleoplasm] (Xenopus tropicalis)

ubqJ [nucleoplasm] (Dictyostelium discoideum)

Ubi-p63E [nucleoplasm] (Drosophila melanogaster)

ubqI [nucleoplasm] (Dictyostelium discoideum)

ubqD [nucleoplasm] (Dictyostelium discoideum)

ubqC [nucleoplasm] (Dictyostelium discoideum)

RPS27A [nucleoplasm] (Bos taurus)

ubqB [nucleoplasm] (Dictyostelium discoideum)

UBC [nucleoplasm] (Sus scrofa)

ubqG [nucleoplasm] (Dictyostelium discoideum)

Homologues of Ub-215-UBB(153-228) [nucleoplasm] (Dictyostelium discoideum)

ubqH [nucleoplasm] (Dictyostelium discoideum)

Ub-215-UBB(153-228) [nucleoplasm] (Caenorhabditis elegans)

Ub-215-UBB(153-228) [nucleoplasm] (Canis familiaris)

Ub-215-UBB(153-228) [nucleoplasm] (Danio rerio)

Ub-215-UBB(153-228) [nucleoplasm] (Gallus gallus)

Ubb [nucleoplasm] (Rattus norvegicus)

Rps27a [nucleoplasm] (Mus musculus)

ubqF [nucleoplasm] (Dictyostelium discoideum)

Modified Residues

Name

ubiquitinylated lysine at 215

Coordinate

215

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001268646.1, NP_001268649.1, NP_061828.1, NP_001268647.1, NP_001268645.1, NP_001268648.1

OpenTargets

ENSG00000170315

HPA

ENSG00000170315-UBB

GeneCards

P0CG47

Ensembl

ENST00000395839, ENST00000395837, ENST00000614404, ENSP00000379178, ENST00000302182, ENSP00000304697, ENSP00000478771, ENSG00000170315, ENSP00000379180

PRO

P0CG47

Pharos - Targets

P0CG47

Orphanet

25118

PDB

6JB7, 5EMZ, 7MYF, 7M2K, 6ASR, 5NVG, 4ZFT, 5GOC, 5GJQ, 5V1Y, 5H7S, 7MEY, 5E6J, 5YT6, 6LP2, 7BBD, 4WLR, 5V1Z, 2MBB, 5IFR, 5GOB, 5O6T, 6TBM, 5CAW, 7MC9, 5CRA, 7W3M, 7W3C, 7DNJ, 8H1T, 5TXK, 5CVO, 6ISU, 5N38, 5KHY, 7W39, 6GZS, 7W3H, 5KGF, 5GOJ, 5D0K, 6FX4, 5ZD0, 5XDP, 4ZPZ, 7RBR, 5JBY, 5JTV, 6KOW, 5ULK, 7NPO, 5YMY, 6FTX, 6IF1, 5O44, 7UV5, 6DGF, 6QK9, 5UJL, 5LN1, 7W3B, 5DFL, 7NBB, 7DNI, 6JB6, 6EI1, 5XPK, 6PZV, 4WUR, 5OHN, 5M93, 5ULH, 6QML, 4UF6, 6MSE, 7OJX, 5GOG, 6XQC, 5ZBU, 7F7X, 2KHW, 7W3K, 6NJG, 7W3G, 7LYC, 5X3O, 6FGE, 6XAA, 6K4I, 7XCT, 6N13, 5JTJ, 6BYH, 5XBO, 2MSG, 5YIK, 4ZFR, 5GOD, 5NLJ, 5VEY, 7W3J, 7QO4, 5N2W, 4ZUX, 4WHV, 5CVM, 6JMA, 7W38, 6MSG, 7E8I, 2N13, 5TOG, 5L9T, 5YIJ, 6K9P, 6MSB, 4XOF, 6FDK, 5VF0, 5WFI, 5X3M, 5LRV, 5EDV, 6O96, 6KOX, 5GO7, 6NJ9, 5X3N, 5CVN, 2MRO, 5OHK, 5LRX, 5GO8, 5IBK, 5DK8, 6XZ1, 5KYD, 5TOF, 7QO5, 5VNZ, 5UJN, 5VO0, 5GOK, 5NL5, 5OHL, 6H4H, 5TUT, 5VZW, 6PGV, 7W3A, 5KYE, 7W3F, 5ULF, 5JG6, 5BNB, 5KYF, 7XCR, 5XK5, 7OJE, 6BVA, 5L8H, 7MYH, 7JMS, 7RMA, 7AY2, 5GOH, 4UEL, 6MSD, 5GOI, 5D0M, 5VZM, 5MNJ, 7W3I, 7W3U, 6FYH, 5XK4, 6QF8, 5K9P, 6C16, 6HEI, 5OHP, 5W46, 5EYA, 6GLC, 5YDR, 5JP3, 6CP2, 6HEK, 5KYC, 5L8W, 5LRW, 6OAM, 7BU0, 7CAP, 6UH5

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15038 DAZP2			0.742	7
UniProt:O95630 STAMBP	1	STAMBP [cytosol] (R-HSA-5693063)	0.683	4
UniProt:Q9BSL1 UBAC1	1	UBAC1 [cytosol] (R-HSA-8851644)	0.666	4
UniProt:P54727 RAD23B	2	RAD23B [nucleoplasm] (R-HSA-62590) RAD23B [cytosol] (R-HSA-8850589)	0.666	5
UniProt:P0C0S8 H2AC11	11	K63polyUb-HIST1H2AG [nucleoplasm] (R-HSA-6783237) Ub-HIST1H2AG [nucleoplasm] (R-HSA-6782508) Ack6-HIST1H2AG [nucleoplasm] (R-HSA-4568595) Me2aR30-HIST1H2AG [nucleoplasm] (R-HSA-5244582) MeR30-HIST1H2AG [nucleoplasm] (R-HSA-5244560) Me2aR4-HIST1H2AG [nucleoplasm] (R-HSA-5244587) MeR4-HIST1H2AG [nucleoplasm] (R-HSA-5244623) Me2aR12-HIST1H2AG [nucleoplasm] (R-HSA-5229305) MeR12-HIST1H2AG [nucleoplasm] (R-HSA-5229206) HIST1H2AG [nucleoplasm] (R-HSA-212084) Ack-HIST1H2AG [nucleoplasm] (R-HSA-4551311)	0.65	14
UniProt:Q9Y3C5 RNF11			0.647	3
UniProt:Q9UJ41 RABGEF1	2	RABGEF1 [early endosome membrane] (R-HSA-2029032) RABGEF1 [cytosol] (R-HSA-8875419)	0.632	6
UniProt:Q9HAU4 SMURF2	2	SMURF2 [cytosol] (R-HSA-173537) SMURF2 [nucleoplasm] (R-HSA-178202)	0.623	4
UniProt:P46934 NEDD4	1	NEDD4 [cytosol] (R-HSA-975992)	0.59	2
UniProt:Q60592 MAST2			0.589	2
UniProt:Q9UJY5 GGA1	2	GGA1 [early endosome membrane] (R-HSA-8854136) GGA1 [endosome membrane] (R-HSA-5692930)	0.581	3
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.564	2
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:Q9NRQ2 PLS4			0.556	3
UniProt:Q8N3F0 MTURN			0.556	3
UniProt:Q96CS7 PKHB2			0.556	3
UniProt:O60260-5 PRKN			0.556	6
UniProt:Q96FW1 OTUB1	2	OTUB1 [cytosol] (R-HSA-933411) OTUB1 [nucleoplasm] (R-HSA-6783242)	0.556	3
UniProt:Q6GQQ9-2 Q6GQQ92			0.556	3
UniProt:O75886 STAM2	2	Ub-STAM2 [cytosol] (R-HSA-6782781) STAM2 [cytosol] (R-HSA-182965)	0.556	3
UniProt:Q8NA23-2 Q8NA232			0.556	3
UniProt:Q9H305 CDIP1			0.556	3
UniProt:P45974-2 USP5			0.556	3
UniProt:Q86VP1 TAX1BP1	1	TAX1BP1 [cytosol] (R-HSA-937346)	0.556	3
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.556	3
UniProt:Q6ICB0 DESI1			0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:P00441 SOD1	5	SOD1 [extracellular region] (R-HSA-350705) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) SOD1 [cytosol] (R-HSA-350697) 2xHC-SOD1 [cytosol] (R-HSA-3299726)	0.556	3
UniProt:P28562 DUSP1	1	DUSP1 [nucleoplasm] (R-HSA-203796)	0.544	2
UniProt:Q96CS3 FAF2	3	FAF2 [cytosol] (R-HSA-6781921) FAF2 [extracellular region] (R-HSA-6806183) FAF2 [azurophil granule lumen] (R-HSA-6799138)	0.527	3
UniProt:Q9DLK6 Q9DLK6			0.524	2
UniProt:P24610	1	Pax3 [nucleoplasm] (R-MMU-5603237)	0.524	2
UniProt:Q8IVM0 CCD50			0.508	2
UniProt:Q9NZ52 GGA3	3	GGA3 [recycling endosome membrane] (R-HSA-8875655) GGA3 [early endosome membrane] (R-HSA-8854137) GGA3 [endosome membrane] (R-HSA-5692936)	0.508	2
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

Cite Us!