Reactome | Ub-C145-UBE2E3 [cytosol]

Ub-C145-UBE2E3 [cytosol]

Stable Identifier

R-HSA-8864162

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquitin-conjugating enzyme E2 E3, UB2E3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q969T4 UBE2E3

Gene Names

UBE2E3, UBCE4, UBCH9

Chain

initiator methionine:1, chain:2-207

Reference Genes

BioGPS Gene:10477 UBE2E3

COSMIC (genes):UBE2E3 UBE2E3

CTD Gene:10477 UBE2E3

dbSNP Gene:10477 UBE2E3

ENSEMBL:ENSG00000170035 UBE2E3

ENSEMBL:ENSG00000170035.16 UBE2E3

HGNC:12479 UBE2E3

KEGG Gene (Homo sapiens):10477 UBE2E3

Monarch:10477 UBE2E3

NCBI Gene:10477 UBE2E3

OMIM:604151 UBE2E3

UCSC:Q969T4 UBE2E3

Reference Transcript

Other Identifiers

10477

11742138_a_at

11742946_s_at

16888232

210024_PM_s_at

210024_s_at

2518164

2518165

2518166

2518167

2518168

2518169

2518172

2518196

2518198

2518199

2518200

2518201

2518202

34850_at

3969607

3969608

8046685

A_23_P11192

A_24_P148450

A_33_P3223713

GE61012

GO:0000166

GO:0003824

GO:0004842

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0016567

GO:0016740

GO:0019787

GO:0036211

GO:0043226

GO:0061631

GO:0070534

GO:0070936

GO:0070979

GO:0140096

HMNXSV003005459

ILMN_1669553

ILMN_1708463

ILMN_1765714

ILMN_1809652

ILMN_2390338

g4586929_3p_a_at

Participates

as a member of

Other forms of this molecule

UBE2E3 [cytosol]

UBE2E3 [nucleoplasm]

Ub-C145-UBE2E3 [nucleoplasm]

Inferred To

Ub-C145-UBE2E3 [cytosol] (Canis familiaris)

Ub-C145-UBE2E3 [cytosol] (Dictyostelium discoideum)

Ub-C145-UBE2E3 [cytosol] (Gallus gallus)

ube2e3 [cytosol] (Xenopus tropicalis)

Ubc2 [cytosol] (Drosophila melanogaster)

Ube2e3 [cytosol] (Mus musculus)

Ube2e3 [cytosol] (Rattus norvegicus)

Dmel\CG5440 [cytosol] (Drosophila melanogaster)

UbcD2 [cytosol] (Danio rerio)

Homologues of Ub-C145-UBE2E3 [cytosol] (Drosophila melanogaster)

UBE2E3 [cytosol] (Bos taurus)

UBE2E3 [cytosol] (Sus scrofa)

ubc-22 [cytosol] (Caenorhabditis elegans)

Modified Residues

Name

S-(glycyl)-L-cysteine (Cys-Gly) at 145

Coordinate

145

PsiMod Name

S-(glycyl)-L-cysteine (Cys-Gly)

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Cross References

RefSeq

NP_872619.1, NP_001265484.1, XP_005246301.1, NP_006348.1, NP_001265483.1

OpenTargets

ENSG00000170035

IntEnz

2.3.2.23

GeneCards

Q969T4

HPA

ENSG00000170035-UBE2E3

Ensembl

ENSP00000473639, ENST00000410062, ENSP00000473623, ENSP00000386788, ENSP00000376215, ENST00000602959, ENSG00000170035, ENST00000392415, ENST00000602710

PRO

Q969T4

Pharos - Targets

Q969T4

HMDB Protein

HMDBP00593

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.556	3
UniProt:Q6ZNA4 RNF111	2	RNF111 [cytosol] (R-HSA-975981) RNF111 [nucleoplasm] (R-HSA-2186765)	0.553	2

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