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DFFB [nucleoplasm]
Stable Identifier
R-HSA-211195
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DFF40/DFFB/CAD
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Apoptosis induced DNA fragmentation (Homo sapiens)
Association of DFF40 with chromatin (Homo sapiens)
DFF40 associated with chromatin [nucleoplasm] (Homo sapiens)
DFF40 homodimer/homooligomer [nucleoplasm] (Homo sapiens)
DFF40 homodimer [nucleoplasm] (Homo sapiens)
DFFB [nucleoplasm] (Homo sapiens)
DFF40 homooligomer [nucleoplasm] (Homo sapiens)
DFFB [nucleoplasm] (Homo sapiens)
DFF40 homodimer/homooligomer [nucleoplasm] (Homo sapiens)
DFF40 homodimer [nucleoplasm] (Homo sapiens)
DFFB [nucleoplasm] (Homo sapiens)
DFF40 homooligomer [nucleoplasm] (Homo sapiens)
DFFB [nucleoplasm] (Homo sapiens)
Caspase 3-mediated cleavage of DFF45 (117) (Homo sapiens)
Caspase cleaved DFFA (117) [nucleoplasm] (Homo sapiens)
DFFB [nucleoplasm] (Homo sapiens)
DFFA:DFFB [nucleoplasm] (Homo sapiens)
DFFB [nucleoplasm] (Homo sapiens)
Cleavage of DFF45 (224) by caspase-3 (Homo sapiens)
Caspase cleaved DFFA (117) [nucleoplasm] (Homo sapiens)
DFFB [nucleoplasm] (Homo sapiens)
caspase-3-cleaved DFFA (117,224):DFFB complex [nucleoplasm] (Homo sapiens)
DFFB [nucleoplasm] (Homo sapiens)
Cleavage of DNA by DFF40 (Homo sapiens)
DFF40 associated with chromatin [nucleoplasm] (Homo sapiens)
DFF40 homodimer/homooligomer [nucleoplasm] (Homo sapiens)
DFF40 homodimer [nucleoplasm] (Homo sapiens)
DFFB [nucleoplasm] (Homo sapiens)
DFF40 homooligomer [nucleoplasm] (Homo sapiens)
DFFB [nucleoplasm] (Homo sapiens)
DFF40 homodimer [nucleoplasm] (Homo sapiens)
DFFB [nucleoplasm] (Homo sapiens)
DFF40 homodimer/homooligomer [nucleoplasm] (Homo sapiens)
DFF40 homodimer [nucleoplasm] (Homo sapiens)
DFFB [nucleoplasm] (Homo sapiens)
DFF40 homooligomer [nucleoplasm] (Homo sapiens)
DFFB [nucleoplasm] (Homo sapiens)
Cleaved fragments of DFF45 dissociate from DFF40 (Homo sapiens)
DFFB [nucleoplasm] (Homo sapiens)
caspase-3-cleaved DFFA (117,224):DFFB complex [nucleoplasm] (Homo sapiens)
DFFB [nucleoplasm] (Homo sapiens)
DFF dissociates from importin-alpha:importin-beta (Homo sapiens)
DFF:associated with the importin-alpha:importin-beta complex [nucleoplasm] (Homo sapiens)
DFFA:DFFB [nucleoplasm] (Homo sapiens)
DFFB [nucleoplasm] (Homo sapiens)
DFFA:DFFB [nucleoplasm] (Homo sapiens)
DFFB [nucleoplasm] (Homo sapiens)
Homodimerization of DFF40 (Homo sapiens)
DFF40 homodimer [nucleoplasm] (Homo sapiens)
DFFB [nucleoplasm] (Homo sapiens)
DFFB [nucleoplasm] (Homo sapiens)
Translocation of DFF to the nucleus (Homo sapiens)
DFF:associated with the importin-alpha:importin-beta complex [nucleoplasm] (Homo sapiens)
DFFA:DFFB [nucleoplasm] (Homo sapiens)
DFFB [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O76075 DFFB
Gene Names
DFFB, CAD, DFF2, DFF40
Chain
chain:1-338
Reference Genes
BioGPS Gene:1677 DFFB
COSMIC (genes):DFFB DFFB
CTD Gene:1677 DFFB
dbSNP Gene:1677 DFFB
ENSEMBL:ENSG00000169598 DFFB
ENSEMBL_homo_sapiens_GENE:ENSG00000169598.17 DFFB
HGNC:2773 DFFB
KEGG Gene (Homo sapiens):1677 DFFB
Monarch:1677 DFFB
NCBI Gene:1677 DFFB
OMIM:601883 DFFB
UCSC:O76075 DFFB
Reference Transcript
RefSeq:NM_001320132.1 DFFB
RefSeq:NM_004402.3 DFFB
Other Identifiers
11731383_a_at
11731384_x_at
11745428_a_at
11745693_a_at
11745694_x_at
11753611_a_at
11753612_x_at
16658231
1677
206752_PM_s_at
206752_s_at
2317419
2317420
2317514
2317515
2317516
2317517
2317518
2317520
2317521
2317522
2317523
2317524
2317529
2317530
2317531
2317532
2317533
2317538
2317539
2317540
2317541
2317542
3203170
34937_at
7897210
A_23_P44546
A_24_P278684
A_33_P3277012
GE54583
GO:0000785
GO:0003677
GO:0003824
GO:0004518
GO:0004520
GO:0004536
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005829
GO:0006308
GO:0006309
GO:0006915
GO:0012501
GO:0016787
GO:0019899
GO:0019904
GO:0030263
GO:0032991
GO:0042802
GO:0043226
GO:0097718
GO:0140097
GO:1902511
HMNXSV003004507
ILMN_1678962
ILMN_2384133
PH_hs_0031751
TC01000074.hg
g4758149_3p_s_at
Participates
as an input of
Homodimerization of DFF40 (Homo sapiens)
as a repeated unit of
DFF40 homooligomer [nucleoplasm] (Homo sapiens)
as a component of
DFF40 homodimer [nucleoplasm] (Homo sapiens)
DFFA:DFFB [nucleoplasm] (Homo sapiens)
caspase-3-cleaved DFFA (117,224):DFFB complex [nucleoplasm] (Homo sapiens)
Caspase cleaved DFFA (117) [nucleoplasm] (Homo sapiens)
as an output of
Cleaved fragments of DFF45 dissociate from DFF40 (Homo sapiens)
Other forms of this molecule
DFFB [cytosol]
Inferred To
Dffb [nucleoplasm]
(Mus musculus)
Dffb [nucleoplasm]
(Rattus norvegicus)
CAD [nucleoplasm]
(Gallus gallus)
Drep4 [nucleoplasm]
(Drosophila melanogaster)
dffb [nucleoplasm]
(Danio rerio)
dffb [nucleoplasm]
(Xenopus tropicalis)
DFFB [nucleoplasm]
(Bos taurus)
DFFB [nucleoplasm]
(Canis familiaris)
DFFB [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_004393.1
,
NP_001307061.1
OpenTargets
ENSG00000169598
GeneCards
O76075
HPA
ENSG00000169598-DFFB
Ensembl
ENSG00000169598
,
ENSP00000367454
,
ENST00000491998
,
ENST00000339350
,
ENST00000378209
,
ENSP00000436775
,
ENSP00000343218
PRO
O76075
Pharos - Targets
O76075
PDB
1IBX
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00273 DFFA
6
DFFA [cytosol]
(R-HSA-211221)
DFFA(1-?) [nucleoplasm]
(R-HSA-211228)
DFFA(225-331) [nucleoplasm]
(R-HSA-211188)
DFFA(118-224) [nucleoplasm]
(R-HSA-211205)
DFFA(118-331) [nucleoplasm]
(R-HSA-211199)
DFFA(1-117) [nucleoplasm]
(R-HSA-211185)
0.909
10
UniProt:P61326 MAGOH
1
MAGOH [nucleoplasm]
(R-HSA-156658)
0.527
2
UniProt:Q16513 PKN2
2
p-T816-PKN2 [cytosol]
(R-HSA-5623652)
PKN2 [cytosol]
(R-HSA-5623612)
0.527
2
UniProt:P0CG47 UBB
20
UBB(77-152) [endocytic vesicle membrane]
(R-HSA-939253)
UBB(1-76) [endocytic vesicle membrane]
(R-HSA-939231)
UBB(153-228) [endocytic vesicle membrane]
(R-HSA-939171)
Ub-33-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783023)
Ub-109-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783008)
Ub-185-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783046)
Ub-215-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783002)
Ub-63-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783148)
Ub-139-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783012)
Ub-158-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783162)
Ub-6-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783014)
Ub-82-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783015)
Ub-163-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783025)
Ub-87-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6782998)
Ub-11-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783109)
Ub-124-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783131)
Ub-200-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783100)
Ub-48-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783165)
Ub-181-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783160)
Ub-29-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783070)
0.527
2
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