Reactome | Ack-HIST1H2AG [nucleoplasm]

Ack-HIST1H2AG [nucleoplasm]

Stable Identifier

R-HSA-4551311

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - HCMV Infection (Homo sapiens)
    - HCMV Early Events (Homo sapiens)
      - Activation of Latent HCMV Genome (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK-histone H2A [nucleoplasm] (Homo sapiens)
        
        AcK-histone HIST1H2A [nucleoplasm] (Homo sapiens)
        
        Ack-HIST1H2AG [nucleoplasm] (Homo sapiens)
      - Delayed Early (DE) Gene Expression (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK-histone H2A [nucleoplasm] (Homo sapiens)
        
        AcK-histone HIST1H2A [nucleoplasm] (Homo sapiens)
        
        Ack-HIST1H2AG [nucleoplasm] (Homo sapiens)
      - Immediate Early (IE) Gene Expression (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK-histone H2A [nucleoplasm] (Homo sapiens)
        
        AcK-histone HIST1H2A [nucleoplasm] (Homo sapiens)
        
        Ack-HIST1H2AG [nucleoplasm] (Homo sapiens)
      - Transcriptional Activation of the HCMV Genome (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK-histone H2A [nucleoplasm] (Homo sapiens)
        
        AcK-histone HIST1H2A [nucleoplasm] (Homo sapiens)
        
        Ack-HIST1H2AG [nucleoplasm] (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK-histone H2A [nucleoplasm] (Homo sapiens)
        
        AcK-histone HIST1H2A [nucleoplasm] (Homo sapiens)
        
        Ack-HIST1H2AG [nucleoplasm] (Homo sapiens)
    - HCMV Late Events (Homo sapiens)
      - Late (L) Gene Expression (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK-histone H2A [nucleoplasm] (Homo sapiens)
        
        AcK-histone HIST1H2A [nucleoplasm] (Homo sapiens)
        
        Ack-HIST1H2AG [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P0C0S8 H2AC11

Gene Names

H2AC11, H2AFP, HIST1H2AG, H2AC13, H2AFC, HIST1H2AI, H2AC15, H2AFD, HIST1H2AK, H2AC16, H2AFI, HIST1H2AL, H2AC17, H2AFN, HIST1H2AM

Chain

initiator methionine:1, chain:2-130

Reference Genes

BioGPS Gene:8329 H2AC11

BioGPS Gene:8330 H2AC11

BioGPS Gene:8332 H2AC11

BioGPS Gene:8336 H2AC11

BioGPS Gene:8969 H2AC11

CTD Gene:8329 H2AC11

CTD Gene:8330 H2AC11

CTD Gene:8332 H2AC11

CTD Gene:8336 H2AC11

CTD Gene:8969 H2AC11

dbSNP Gene:8329 H2AC11

dbSNP Gene:8330 H2AC11

dbSNP Gene:8332 H2AC11

dbSNP Gene:8336 H2AC11

dbSNP Gene:8969 H2AC11

ENSEMBL:ENSG00000196747 HIST1H2AI

ENSEMBL:ENSG00000196787 HIST1H2AG

ENSEMBL:ENSG00000275221 HIST1H2AK

ENSEMBL:ENSG00000276903 HIST1H2AL

ENSEMBL:ENSG00000278677 HIST1H2AM

HGNC:4725 H2AC11

HGNC:4726 H2AC11

HGNC:4730 H2AC11

HGNC:4735 H2AC11

HGNC:4737 H2AC11

KEGG Gene (Homo sapiens):8329 H2AC11

KEGG Gene (Homo sapiens):8330 H2AC11

KEGG Gene (Homo sapiens):8332 H2AC11

KEGG Gene (Homo sapiens):8336 H2AC11

KEGG Gene (Homo sapiens):8969 H2AC11

Monarch:8329 H2AC11

Monarch:8330 H2AC11

Monarch:8332 H2AC11

Monarch:8336 H2AC11

Monarch:8969 H2AC11

NCBI Gene:8329 H2AC11

NCBI Gene:8330 H2AC11

NCBI Gene:8332 H2AC11

NCBI Gene:8336 H2AC11

NCBI Gene:8969 H2AC11

OMIM:602787 H2AC11

OMIM:602788 H2AC11

OMIM:602793 H2AC11

OMIM:602796 H2AC11

OMIM:615012 H2AC11

UCSC:P0C0S8 H2AC11

Reference Transcript

Other Identifiers

0001240113

0001940154

0003450239

0005080484

0005340519

11715162_s_at

11715219_s_at

11734234_at

11737572_x_at

11740124_at

11740125_x_at

11759131_at

11759220_at

11759248_at

17005787

17005858

17005876

17016496

17016512

207156_at

208583_x_at

214542_x_at

214554_at

284_at

285_g_at

2899757

2899758

2899759

2899760

2899761

2899762

2899763

2899764

2899765

2899767

2900048

2900094

2900095

2900096

2947042

2947043

2947044

2947045

2947065

2947066

2947103

2947104

2947105

31749_f_at

31768_at

33023_at

34156_i_at

34157_f_at

8117535

8117580

8117608

8124524

8124540

8329

8330

8332

8336

8969

ADDON002309.hg

ADDON002495.hg

ADDON002786.hg

ADDON002787.hg

ADDON002823.hg

A_14_P122277

A_14_P122573

A_14_P200168

A_14_P200169

A_21_P0000197

A_23_P168014

A_23_P363174

A_24_P217848

A_24_P303354

A_24_P394510

A_24_P414658

A_24_P86389

A_32_P221799

A_33_P3360216

GE535482

GE57662

GE81292

GE81293

GE81294

GO:0000228

GO:0000786

GO:0000790

GO:0003674

GO:0003677

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005694

GO:0006325

GO:0006342

GO:0008150

GO:0009058

GO:0019899

GO:0032991

GO:0034641

GO:0043226

GO:0046982

GO:0051276

GO:0070062

Hs.137592.0.S1_3p_at

Hs.137592.0.S1_3p_x_at

Hs.233568.0.S1_3p_at

ILMN_1663453

ILMN_1686478

ILMN_1694699

ILMN_1756022

ILMN_1789512

ILMN_2184602

ILMN_3246993

L19778_at

PH_hs_0007861

PH_hs_0028903

PH_hs_0031765

PH_hs_0037184

TC06000223.hg

TC06000269.hg

TC06001425.hg

TC06001430.hg

TC06004063.hg

Z83742_at

g10800131_3p_at

Participant Of

hasMember

AcK-histone HIST1H2A [nucleoplasm]

Other forms of this molecule

K63polyUb-HIST1H2AG [nucleoplasm]

Ub-HIST1H2AG [nucleoplasm]

Ack6-HIST1H2AG [nucleoplasm]

Me2aR30-HIST1H2AG [nucleoplasm]

MeR30-HIST1H2AG [nucleoplasm]

Me2aR4-HIST1H2AG [nucleoplasm]

MeR4-HIST1H2AG [nucleoplasm]

Me2aR12-HIST1H2AG [nucleoplasm]

MeR12-HIST1H2AG [nucleoplasm]

HIST1H2AG [nucleoplasm]

Inferred To

hta2 [nucleoplasm] (Schizosaccharomyces pombe)

LOC101735111 [nucleoplasm] (Xenopus tropicalis)

Ack-HIST1H2AB [nucleoplasm] (Plasmodium falciparum)

Ack-HIST1H2AB [nucleoplasm] (Xenopus tropicalis)

HTA1 [nucleoplasm] (Saccharomyces cerevisiae)

H2AC10 [nucleoplasm] (Bos taurus)

HTA2 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of Ack-HIST1H2AG [nucleoplasm] (Xenopus tropicalis)

H2Av2 [nucleoplasm] (Dictyostelium discoideum)

h2ax [nucleoplasm] (Danio rerio)

Homologues of Ack-HIST1H2AB [nucleoplasm] (Danio rerio)

Homologues of Ack-HIST1H2AB [nucleoplasm] (Dictyostelium discoideum)

Homologues of Ack-HIST1H2AB [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of Ack-HIST1H2AB [nucleoplasm] (Schizosaccharomyces pombe)

h2ac14 [nucleoplasm] (Xenopus tropicalis)

H2AX [nucleoplasm] (Dictyostelium discoideum)

H2Av3 [nucleoplasm] (Dictyostelium discoideum)

htas-1 [nucleoplasm] (Caenorhabditis elegans)

h2afx.2 [nucleoplasm] (Xenopus tropicalis)

H2Av1 [nucleoplasm] (Dictyostelium discoideum)

h2ac12 [nucleoplasm] (Xenopus tropicalis)

hta1 [nucleoplasm] (Schizosaccharomyces pombe)

ppard [nucleoplasm] (Xenopus tropicalis)

LOC100157763 [nucleoplasm] (Sus scrofa)

H2AC14 [nucleoplasm] (Canis familiaris)

si:ch211-113a14.19 [nucleoplasm] (Danio rerio)

Modified Residues

Name

N6-acetyl-L-lysine at unknown position

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Cross References

RefSeq

NP_003501.1, NP_003500.1, NP_003502.1, NP_066408.1, NP_003505.1

Target Pathogen

57c08b76be737e1cc0a95c6b, 57c08b76be737e1cc0a95c69, 57c09037be737e1cc0a96c46

OpenTargets

ENSG00000196787

HPA

ENSG00000196787-HIST1H2AG, ENSG00000276903-HIST1H2AL, ENSG00000275221-HIST1H2AK, ENSG00000196747-HIST1H2AI, ENSG00000278677-HIST1H2AM

GeneCards

P0C0S8

Ensembl

ENSG00000196747, ENSG00000275221, ENST00000359193, ENST00000358739, ENST00000613174, ENSP00000482538, ENSG00000278677, ENSP00000482431, ENSP00000352119, ENSP00000351589, ENSP00000352627, ENSG00000196787, ENST00000618958, ENSG00000276903, ENST00000359611

PRO

P0C0S8

HMDB Protein

HMDBP07725

PDB

6R0C, 6RNY, 5KGF, 4QYL

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) SUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418)	0.672	21
UniProt:P0CG47 UBB	109	UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-110-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-186-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-182-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070) Ub-106-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783103) Ub-27-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783038) Ub-180-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783114) Ub-104-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783149) N6-glycyl-L-lysine-UBB(1-76) [cytosol] (R-HSA-8869049) N6-glycyl-L-lysine-UBB(153-228) [cytosol] (R-HSA-8869046) N6-glycyl-L-lysine-UBB(77-152) [cytosol] (R-HSA-8869047) adenylatedG152-UBB(77-152) [nucleoplasm] (R-HSA-8852094) adenylatedG228-UBB(153-228) [nucleoplasm] (R-HSA-8852104) adenylatedG76-UBB(1-76) [nucleoplasm] (R-HSA-8852101) UBB [cytosol] (R-HSA-8853516) adenylatedG76-UBB(1-76) [cytosol] (R-HSA-8852121) adenylatedG228-UBB(153-228) [cytosol] (R-HSA-8852049) adenylatedG152-UBB(77-152) [cytosol] (R-HSA-8852113) Ub-124-UBB(77-152) [endoplasmic reticulum membrane] (R-HSA-8943100) Ub-48-UBB(1-76) [endoplasmic reticulum membrane] (R-HSA-8943138) Ub-200-UBB(153-228) [endoplasmic reticulum membrane] (R-HSA-8943117) UBB(153-228) [plasma membrane] (R-HSA-3149455) UBB(1-76) [plasma membrane] (R-HSA-3149453) UBB(77-152) [plasma membrane] (R-HSA-3149463) UBB(77-152) [endosome membrane] (R-HSA-939251) UBB(1-76) [endosome membrane] (R-HSA-939240) UBB(153-228) [endosome membrane] (R-HSA-939247) UBB(153-228) [endoplasmic reticulum membrane] (R-HSA-8943098) UBB(77-152) [endoplasmic reticulum membrane] (R-HSA-8943111) UBB(1-76) [endoplasmic reticulum membrane] (R-HSA-8943078) Ub-106-UBB(77-152) [cytosol] (R-HSA-5689191) Ub-182-UBB(153-228) [cytosol] (R-HSA-5689214) Ub-29-UBB(1-76) [cytosol] (R-HSA-5689207) Ub-158-UBB(153-228) [cytosol] (R-HSA-5689099) Ub-82-UBB(77-152) [cytosol] (R-HSA-5689080) Ub-6-UBB(1-76) [cytosol] (R-HSA-5689075) Ub-33-UBB(1-76) [cytosol] (R-HSA-5689198) Ub-186-UBB(153-228) [cytosol] (R-HSA-5689146) Ub-110-UBB(77-152) [cytosol] (R-HSA-5689203) Ub-27-UBB(1-76) [cytosol] (R-HSA-5689161) Ub-104-UBB(77-152) [cytosol] (R-HSA-5689139) Ub-180-UBB(153-228) [cytosol] (R-HSA-5689138) Ub-11-UBB(1-76) [cytosol] (R-HSA-3095929) Ub-163-UBB(153-228) [cytosol] (R-HSA-3095932) Ub-87-UBB(77-152) [cytosol] (R-HSA-3095917) Ub-139-UBB(77-152) [endosome membrane] (R-HSA-939217) Ub-215-UBB(153-228) [endosome membrane] (R-HSA-939193) Ub-63-UBB(1-76) [endosome membrane] (R-HSA-939167) Ub-139-UBB(77-152) [plasma membrane] (R-HSA-939867) Ub-63-UBB(1-76) [plasma membrane] (R-HSA-939872) Ub-215-UBB(153-228) [plasma membrane] (R-HSA-939852) Ub-27-UBB(1-76) [nucleoplasm] (R-HSA-6782673) Ub-180-UBB(153-228) [nucleoplasm] (R-HSA-6782604) Ub-104-UBB(77-152) [nucleoplasm] (R-HSA-6782627) Ub-106-UBB(77-152) [nucleoplasm] (R-HSA-6782652) Ub-182-UBB(153-228) [nucleoplasm] (R-HSA-6782665) Ub-29-UBB(1-76) [nucleoplasm] (R-HSA-6782595) Ub-124-UBB(77-152) [nucleoplasm] (R-HSA-6782527) Ub-48-UBB(1-76) [nucleoplasm] (R-HSA-6782505) Ub-200-UBB(153-228) [nucleoplasm] (R-HSA-6782478) Ub-11-UBB(1-76) [nucleoplasm] (R-HSA-6782649) Ub-87-UBB(77-152) [nucleoplasm] (R-HSA-6782607) Ub-163-UBB(153-228) [nucleoplasm] (R-HSA-6782598) Ub-186-UBB(153-228) [nucleoplasm] (R-HSA-6782655) Ub-110-UBB(77-152) [nucleoplasm] (R-HSA-6782591) Ub-33-UBB(1-76) [nucleoplasm] (R-HSA-6782601) UBB(77-152) [nucleoplasm] (R-HSA-939870) UBB(1-76) [nucleoplasm] (R-HSA-939847) UBB(153-228) [nucleoplasm] (R-HSA-939854) Ub-48-UBB(1-76) [nucleoplasm] (R-HSA-5683040) Ub-124-UBB(77-152) [nucleoplasm] (R-HSA-5683036) Ub-200-UBB(153-228) [nucleoplasm] (R-HSA-5683038) Ub-139-UBB(77-152) [nucleoplasm] (R-HSA-6782488) Ub-63-UBB(1-76) [nucleoplasm] (R-HSA-6782489) Ub-215-UBB(153-228) [nucleoplasm] (R-HSA-6782475) Ub-82-UBB(77-152) [nucleoplasm] (R-HSA-6782683) Ub-6-UBB(1-76) [nucleoplasm] (R-HSA-6782600) Ub-158-UBB(153-228) [nucleoplasm] (R-HSA-6782639) UBB(153-228) [late endosome lumen] (R-HSA-9660014) UBB(77-152) [late endosome lumen] (R-HSA-9660021) UBB(1-76) [late endosome lumen] (R-HSA-9660017) Ub-48-UBB(1-76) [cytosol] (R-HSA-939249) Ub-124-UBB(77-152) [cytosol] (R-HSA-939225) Ub-200-UBB(153-228) [cytosol] (R-HSA-939197) UBB(153-228) [cytosol] (R-HSA-939230) UBB(77-152) [cytosol] (R-HSA-939213) UBB(1-76) [cytosol] (R-HSA-939214) UBB(77-152) [lysosomal lumen] (R-HSA-9660011) UBB(1-76) [lysosomal lumen] (R-HSA-9660024) UBB(153-228) [lysosomal lumen] (R-HSA-9660025) Ub-63-UBB(1-76) [cytosol] (R-HSA-939224) Ub-215-UBB(153-228) [cytosol] (R-HSA-939168) Ub-139-UBB(77-152) [cytosol] (R-HSA-939235)	0.65	14
UniProt:P84233 Histone H3.2	2	Histone H3.2 [nucleoplasm] (R-XLA-4549227) Ack15-histone H3.2 [nucleoplasm] (R-XLA-4549248)	0.65	14
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.564	2
UniProt:Q13547 HDAC1	2	SUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030) HDAC1 [nucleoplasm] (R-HSA-205021)	0.527	2
UniProt:O95760 IL33	3	PolyUb-IL33 [nucleoplasm] (R-HSA-6783057) IL33 [extracellular region] (R-HSA-448567) IL33 [nucleoplasm] (R-HSA-6783145)	0.499	3

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