Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
FNTB [cytosol]
Stable Identifier
R-HSA-2530482
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein farnesyltransferase subunit beta, FNTB_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
FNTB inhibitors bind FNTA:FNTB (Homo sapiens)
FNTA:FNTB [cytosol] (Homo sapiens)
FNTB [cytosol] (Homo sapiens)
FNTA:FNTB:FTase inhibitors [cytosol] (Homo sapiens)
FNTA:FNTB [cytosol] (Homo sapiens)
FNTB [cytosol] (Homo sapiens)
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
The phototransduction cascade (Homo sapiens)
Inactivation, recovery and regulation of the phototransduction cascade (Homo sapiens)
FNTA:FNTB transfers FARN to GNGT1 (Homo sapiens)
FNTA:FNTB [cytosol] (Homo sapiens)
FNTB [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS processing (Homo sapiens)
FNTB inhibitors bind FNTA:FNTB (Homo sapiens)
FNTA:FNTB [cytosol] (Homo sapiens)
FNTB [cytosol] (Homo sapiens)
FNTA:FNTB:FTase inhibitors [cytosol] (Homo sapiens)
FNTA:FNTB [cytosol] (Homo sapiens)
FNTB [cytosol] (Homo sapiens)
pro-RAS proteins are farnesylated (Homo sapiens)
FNTA:FNTB [cytosol] (Homo sapiens)
FNTB [cytosol] (Homo sapiens)
FNTA:FNTB:FTase inhibitors [cytosol] (Homo sapiens)
FNTA:FNTB [cytosol] (Homo sapiens)
FNTB [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49356 FNTB
Gene Names
FNTB
Chain
chain:1-437
Reference Genes
BioGPS Gene:100529261 FNTB
BioGPS Gene:2342 FNTB
COSMIC (genes):FNTB FNTB
CTD Gene:100529261 FNTB
CTD Gene:2342 FNTB
dbSNP Gene:100529261 FNTB
dbSNP Gene:2342 FNTB
ENSEMBL:ENSG00000257365 FNTB
HGNC:3785 FNTB
KEGG:hsa:100529261 FNTB
KEGG:hsa:2342 FNTB
Monarch:100529261 FNTB
Monarch:2342 FNTB
NCBI Gene:100529261 FNTB
NCBI Gene:2342 FNTB
OMIM:134636 FNTB
UCSC:P49356 FNTB
Reference Transcript
RefSeq:NM_002028.3 FNTB
RefSeq:NM_001202558.1 FNTB
Other Identifiers
100529261
11718033_a_at
11749762_a_at
11757811_s_at
1773_PM_at
1773_at
204764_PM_at
204764_at
225851_PM_at
225851_at
2342
3540401
3540402
3540403
3540404
3540405
3540406
3540407
3540408
3540409
3540414
3540419
3540420
3540421
3540422
3540423
3540424
3540428
3540430
3540431
3540432
3540433
3540434
3540435
3540436
3540438
3540439
3540440
3540443
3540444
3540447
3540451
3540452
37488_at
51164_at
7975121
A_14_P109310
A_14_P121438
A_14_P122411
A_23_P25835
A_24_P124831
GE57543
GO:0003824
GO:0004659
GO:0004660
GO:0005515
GO:0005829
GO:0005875
GO:0005965
GO:0006629
GO:0008270
GO:0008318
GO:0016740
GO:0018343
GO:0046872
GO:0097354
GO:0140096
HMNXSV003049239
Hs.276.0.A1_3p_at
ILMN_1728517
L00635_at
PH_hs_0000037
TC14002300.hg
g10835058_3p_s_at
Participates
as a component of
FNTA:FNTB [cytosol] (Homo sapiens)
Inferred To
FNTB [cytosol]
(Bos taurus)
FNTB [cytosol]
(Dictyostelium discoideum)
FNTB [cytosol]
(Gallus gallus)
FNTB [cytosol]
(Mus musculus)
FNTB [cytosol]
(Plasmodium falciparum)
FNTB [cytosol]
(Rattus norvegicus)
FNTB [cytosol]
(Saccharomyces cerevisiae)
FNTB [cytosol]
(Schizosaccharomyces pombe)
Fntb [cytosol]
(Drosophila melanogaster)
fntb-1 [cytosol]
(Caenorhabditis elegans)
fntb [cytosol]
(Danio rerio)
fntb [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001189487.1
,
NP_002019.1
Guide to Pharmacology - Targets
2826
OpenTargets
ENSG00000257365
ENSEMBL
ENSP00000246166
,
ENST00000246166
HPA
ENSG00000257365-FNTB
ZINC - Substances
FNTB_HUMAN
ZINC target
P49356
PRO
P49356
Pharos - Targets
P49356
PDB
3E37
,
1LD8
,
1LD7
,
2IEJ
,
2F0Y
,
1S63
,
1MZC
,
2H6G
,
2H6F
,
1JCQ
,
2H6I
,
2H6H
,
1SA4
,
1TN6
HMDB Protein
HMDBP10637
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49354 FNTA
3
FNTA(59-379) [cytosol]
(R-HSA-202872)
FNTA(1-59) [cytosol]
(R-HSA-202869)
FNTA(2-379) [cytosol]
(R-HSA-2530516)
0.955
16
UniProt:P31273 HOXC8
1
HOXC8 [nucleoplasm]
(R-HSA-3222311)
0.556
3
UniProt:P49454 CENPF
1
CENPF [cytosol]
(R-HSA-376229)
0.527
3
UniProt:O60906 SMPD2
1
SMPD2 [plasma membrane]
(R-HSA-194337)
0.527
2
UniProt:P0CG47 UBB
20
UBB(77-152) [endocytic vesicle membrane]
(R-HSA-939253)
UBB(1-76) [endocytic vesicle membrane]
(R-HSA-939231)
UBB(153-228) [endocytic vesicle membrane]
(R-HSA-939171)
Ub-33-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783023)
Ub-109-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783008)
Ub-185-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783046)
Ub-215-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783002)
Ub-63-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783148)
Ub-139-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783012)
Ub-158-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783162)
Ub-6-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783014)
Ub-82-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783015)
Ub-163-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783025)
Ub-87-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6782998)
Ub-11-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783109)
Ub-124-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783131)
Ub-200-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783100)
Ub-48-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783165)
Ub-181-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783160)
Ub-29-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783070)
0.527
2
UniProt:O15498 YKT6
5
PalmC-YKT6 [Golgi membrane]
(R-HSA-6808792)
PalmC-YKT6 [transport vesicle]
(R-HSA-6808794)
PalmC-YKT6 [endoplasmic reticulum membrane]
(R-HSA-5688145)
PalmC-YKT6 [ER to Golgi transport vesicle membrane]
(R-HSA-5688557)
PalmC-YKT6 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688558)
0.527
3
UniProt:Q13627 DYRK1A
1
DYRK1A [nucleoplasm]
(R-HSA-1362267)
0.527
4
UniProt:P01185 AVP
10
AVP(20-28) [extracellular region]
(R-HSA-388474)
AVP(20-28) [cytosol]
(R-HSA-879509)
AVP E47del [extracellular region]
(R-HSA-5621396)
AVP P7L [extracellular region]
(R-HSA-5621460)
AVP C67* [extracellular region]
(R-HSA-5621431)
AVP V67A [extracellular region]
(R-HSA-5621446)
AVP A1T [extracellular region]
(R-HSA-5621473)
AVP Y2H [extracellular region]
(R-HSA-5621449)
AVP G23R [extracellular region]
(R-HSA-5621464)
AVP(20-28) [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869075)
0.527
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text