Reactome | FNTB [cytosol]

FNTB [cytosol]

Stable Identifier

R-HSA-2530482

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein farnesyltransferase subunit beta, FNTB_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        FNTB inhibitors bind FNTA:FNTB (Homo sapiens)
        
        FNTA:FNTB [cytosol] (Homo sapiens)
        
        FNTB [cytosol] (Homo sapiens)
        
        FNTA:FNTB:FTase inhibitors [cytosol] (Homo sapiens)
        
        FNTA:FNTB [cytosol] (Homo sapiens)
        
        FNTB [cytosol] (Homo sapiens)

Sensory Perception (Homo sapiens)

- Visual phototransduction (Homo sapiens)
  - The phototransduction cascade (Homo sapiens)
    - Inactivation, recovery and regulation of the phototransduction cascade (Homo sapiens)
      - FNTA:FNTB transfers FARN to GNGT1 (Homo sapiens)
        
        FNTA:FNTB [cytosol] (Homo sapiens)
        
        FNTB [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P49356 FNTB

Gene Names

FNTB

Chain

chain:1-437

Reference Genes

BioGPS Gene:100529261 FNTB

BioGPS Gene:2342 FNTB

COSMIC (genes):FNTB FNTB

CTD Gene:100529261 FNTB

CTD Gene:2342 FNTB

dbSNP Gene:100529261 FNTB

dbSNP Gene:2342 FNTB

ENSEMBL:ENSG00000257365 FNTB

HGNC:3785 FNTB

KEGG:hsa:100529261 FNTB

KEGG:hsa:2342 FNTB

Monarch:100529261 FNTB

Monarch:2342 FNTB

NCBI Gene:100529261 FNTB

NCBI Gene:2342 FNTB

OMIM:134636 FNTB

UCSC:P49356 FNTB

Reference Transcript

Other Identifiers

100529261

11718033_a_at

11749762_a_at

11757811_s_at

1773_PM_at

1773_at

204764_PM_at

204764_at

225851_PM_at

225851_at

2342

3540401

3540402

3540403

3540404

3540405

3540406

3540407

3540408

3540409

3540414

3540419

3540420

3540421

3540422

3540423

3540424

3540428

3540430

3540431

3540432

3540433

3540434

3540435

3540436

3540438

3540439

3540440

3540443

3540444

3540447

3540451

3540452

37488_at

51164_at

7975121

A_14_P109310

A_14_P121438

A_14_P122411

A_23_P25835

A_24_P124831

GE57543

GO:0003824

GO:0004659

GO:0004660

GO:0005515

GO:0005829

GO:0005875

GO:0005965

GO:0006629

GO:0008270

GO:0008318

GO:0016740

GO:0018343

GO:0046872

GO:0097354

GO:0140096

HMNXSV003049239

Hs.276.0.A1_3p_at

ILMN_1728517

L00635_at

PH_hs_0000037

TC14002300.hg

g10835058_3p_s_at

Participates

as a component of

FNTA:FNTB [cytosol] (Homo sapiens)

Inferred To

FNTB [cytosol] (Bos taurus)

FNTB [cytosol] (Dictyostelium discoideum)

FNTB [cytosol] (Gallus gallus)

FNTB [cytosol] (Mus musculus)

FNTB [cytosol] (Plasmodium falciparum)

FNTB [cytosol] (Rattus norvegicus)

FNTB [cytosol] (Saccharomyces cerevisiae)

FNTB [cytosol] (Schizosaccharomyces pombe)

Fntb [cytosol] (Drosophila melanogaster)

fntb-1 [cytosol] (Caenorhabditis elegans)

fntb [cytosol] (Danio rerio)

fntb [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001189487.1, NP_002019.1

Guide to Pharmacology - Targets

2826

OpenTargets

ENSG00000257365

ENSEMBL

ENSP00000246166, ENST00000246166

HPA

ENSG00000257365-FNTB

ZINC - Substances

FNTB_HUMAN

ZINC target

P49356

PRO

P49356

Pharos - Targets

P49356

PDB

3E37, 1LD8, 1LD7, 2IEJ, 2F0Y, 1S63, 1MZC, 2H6G, 2H6F, 1JCQ, 2H6I, 2H6H, 1SA4, 1TN6

HMDB Protein

HMDBP10637

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49354 FNTA	3	FNTA(59-379) [cytosol] (R-HSA-202872) FNTA(1-59) [cytosol] (R-HSA-202869) FNTA(2-379) [cytosol] (R-HSA-2530516)	0.955	16
UniProt:P31273 HOXC8	1	HOXC8 [nucleoplasm] (R-HSA-3222311)	0.556	3
UniProt:P49454 CENPF	1	CENPF [cytosol] (R-HSA-376229)	0.527	3
UniProt:O60906 SMPD2	1	SMPD2 [plasma membrane] (R-HSA-194337)	0.527	2
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.527	2
UniProt:O15498 YKT6	5	PalmC-YKT6 [Golgi membrane] (R-HSA-6808792) PalmC-YKT6 [transport vesicle] (R-HSA-6808794) PalmC-YKT6 [endoplasmic reticulum membrane] (R-HSA-5688145) PalmC-YKT6 [ER to Golgi transport vesicle membrane] (R-HSA-5688557) PalmC-YKT6 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688558)	0.527	3
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.527	4
UniProt:P01185 AVP	10	AVP(20-28) [extracellular region] (R-HSA-388474) AVP(20-28) [cytosol] (R-HSA-879509) AVP E47del [extracellular region] (R-HSA-5621396) AVP P7L [extracellular region] (R-HSA-5621460) AVP C67* [extracellular region] (R-HSA-5621431) AVP V67A [extracellular region] (R-HSA-5621446) AVP A1T [extracellular region] (R-HSA-5621473) AVP Y2H [extracellular region] (R-HSA-5621449) AVP G23R [extracellular region] (R-HSA-5621464) AVP(20-28) [clathrin-coated endocytic vesicle membrane] (R-HSA-8869075)	0.527	2

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