Reactome | GGA3 [early endosome membrane]

GGA3 [early endosome membrane]

Stable Identifier

R-HSA-8854137

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

early endosome membrane

Synonyms

ADP-ribosylation factor-binding protein GGA3, GGA3_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Rab regulation of trafficking (Homo sapiens)
    - TBC/RABGAPs (Homo sapiens)
      - TBC1D3 associates with RAB5 (Homo sapiens)
        
        GGA1,2,3:RAB5:GTP:RABGEF1 [early endosome membrane] (Homo sapiens)
        
        GGA1,2,3 [early endosome membrane] (Homo sapiens)
        
        GGA3 [early endosome membrane] (Homo sapiens)
        
        TBC1D3:GGA:RAB5:GTP:RABGEF1 [early endosome membrane] (Homo sapiens)
        
        GGA1,2,3:RAB5:GTP:RABGEF1 [early endosome membrane] (Homo sapiens)
        
        GGA1,2,3 [early endosome membrane] (Homo sapiens)
        
        GGA3 [early endosome membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NZ52 GGA3

Gene Names

GGA3, KIAA0154

Chain

chain:1-723

Reference Genes

BioGPS Gene:23163 GGA3

COSMIC (genes):GGA3 GGA3

CTD Gene:23163 GGA3

dbSNP Gene:23163 GGA3

ENSEMBL:ENSG00000125447 GGA3

ENSEMBL_homo_sapiens_GENE:ENSG00000125447.18 GGA3

HGNC:17079 GGA3

KEGG Gene (Homo sapiens):23163 GGA3

Monarch:23163 GGA3

NCBI Gene:23163 GGA3

OMIM:606006 GGA3

UCSC:Q9NZ52 GGA3

Reference Transcript

Other Identifiers

11734365_a_at

11739388_a_at

11746601_a_at

11746602_a_at

11749714_a_at

16848761

209411_PM_s_at

209411_s_at

211815_PM_s_at

211815_s_at

23163

3770664

3770665

3770666

3770667

3770669

3770670

3770672

3770674

3770676

3770677

3770679

3770681

3770682

3770683

3770684

3770685

3770688

3770689

3770697

3770698

37959_at

8018324

A_23_P38181

D63876_at

GE57281

GO:0005515

GO:0005764

GO:0005768

GO:0005769

GO:0005773

GO:0005794

GO:0005802

GO:0006622

GO:0006886

GO:0006893

GO:0008289

GO:0010008

GO:0015031

GO:0016020

GO:0016192

GO:0030163

GO:0031267

GO:0031410

GO:0031647

GO:0031648

GO:0031901

GO:0032456

GO:0032991

GO:0034394

GO:0035091

GO:0043001

GO:0043130

GO:0043226

GO:0044877

GO:0045732

GO:0051641

GO:0055037

GO:0055038

GO:0061462

GO:0072659

GO:0097708

GO:1902430

HMNXSV003022368

HMNXSV003058392

Hs.87726.0.S2_3p_a_at

ILMN_1675982

ILMN_1751135

ILMN_2402972

PH_hs_0004921

TC17001874.hg

TC17002786.hg

g7229485_3p_a_at

Participates

as a member of

GGA1,2,3 [early endosome membrane] (Homo sapiens)

as an input of

GGA3 associates with activated MET receptor (Homo sapiens)

Other forms of this molecule

GGA3 [endosome membrane]

GGA3 [recycling endosome membrane]

Inferred To

gga3 [early endosome membrane] (Xenopus tropicalis)

GGA3 [early endosome membrane] (Bos taurus)

GGA3 [early endosome membrane] (Canis familiaris)

GGA3 [early endosome membrane] (Gallus gallus)

GGA3 [early endosome membrane] (Sus scrofa)

Gga [early endosome membrane] (Drosophila melanogaster)

apt-9 [early endosome membrane] (Caenorhabditis elegans)

Gga3 [early endosome membrane] (Mus musculus)

Gga3 [early endosome membrane] (Rattus norvegicus)

gga3a [early endosome membrane] (Danio rerio)

Cross References

RefSeq

NP_001166174.1, NP_001278570.1, NP_054720.1, NP_619525.1, NP_001166175.1, NP_001278571.1

OpenTargets

ENSG00000125447

HPA

ENSG00000125447-GGA3

GeneCards

Q9NZ52

Ensembl

ENST00000649398, ENSP00000438085, ENST00000538886, ENSP00000446421, ENST00000578348, ENSG00000125447, ENSP00000463288, ENSP00000462081, ENSP00000496890, ENST00000582717, ENST00000537686

PRO

Q9NZ52

Pharos - Targets

Q9NZ52

HMDB Protein

HMDBP08422

PDB

1P4U, 1JPL, 1LF8, 1JUQ, 1YD8, 1WR6

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11717 IGF2R	7	IGF2R [clathrin-coated endocytic vesicle membrane] (R-HSA-8869091) IGF2R [Golgi membrane] (R-HSA-434345) IGF2R [cytoplasmic vesicle membrane] (R-HSA-434213) IGF2R [transport vesicle] (R-HSA-6814609) IGF2R [trans-Golgi network membrane] (R-HSA-6814608) IGF2R [plasma membrane] (R-HSA-6806532) IGF2R [secretory granule membrane] (R-HSA-6803320)	0.761	8
UniProt:Q15276 RABEP1	1	RABEP1 [early endosome membrane] (R-HSA-2029004)	0.698	12
UniProt:P84080	2	ARF1 [cytosol] (R-BTA-200826) ARF1 [Golgi membrane] (R-BTA-199971)	0.646	3
UniProt:Q13258 PTGDR	1	PTGDR [plasma membrane] (R-HSA-391830)	0.61	5
UniProt:P62330 ARF6	2	ARF6 [recycling endosome membrane] (R-HSA-2029049) ARF6 [cytosol] (R-HSA-8871121)	0.589	3
UniProt:P20645 M6PR	6	M6PR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869100) M6PR [plasma membrane] (R-HSA-8864564) M6PR [Golgi membrane] (R-HSA-429824) M6PR [lysosomal membrane] (R-HSA-432696) M6PR [trans-Golgi network membrane] (R-HSA-6814611) M6PR [transport vesicle] (R-HSA-6814613)	0.573	2
UniProt:Q6VY07 PACS1	1	PACS1 [cytosol] (R-HSA-167634)	0.544	5
UniProt:P56817 BACE1	8	BACE1 [endoplasmic reticulum lumen] (R-HSA-6783326) 7K-BACE1 [endoplasmic reticulum lumen] (R-HSA-5693006) BACE1(22-45) [Golgi-associated vesicle lumen] (R-HSA-5693069) 7K-BACE1 [Golgi-associated vesicle lumen] (R-HSA-5693095) 7K-BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693106) BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693105) BACE1(46-501) [plasma membrane] (R-HSA-5692933) BACE1 [endosome membrane] (R-HSA-5692942)	0.544	2
UniProt:P18272 NCAP			0.524	2
UniProt:Q9UJY4 GGA2	2	GGA2 [early endosome membrane] (R-HSA-8854140) GGA2 [endosome membrane] (R-HSA-5692937)	0.508	3
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.508	2
UniProt:Q9UJY5 GGA1	2	GGA1 [early endosome membrane] (R-HSA-8854136) GGA1 [endosome membrane] (R-HSA-5692930)	0.508	4

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