Reactome | YAF2 [nucleoplasm]

YAF2 [nucleoplasm]

Stable Identifier

R-HSA-8937973

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

YY1-associated factor 2, YAF2_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by E2F6 (Homo sapiens)
      - CBX3 and PRC1.6 associate with E2F6.com-1 (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
        
        PRC1.6 (PCGF6:L3MBTL2:RING1,RNF2:YAF2) [nucleoplasm] (Homo sapiens)
        
        YAF2 [nucleoplasm] (Homo sapiens)
        
        PRC1.6 (PCGF6:L3MBTL2:RING1,RNF2:YAF2) [nucleoplasm] (Homo sapiens)
        
        YAF2 [nucleoplasm] (Homo sapiens)
      - E2F1 gene transcription is inhibited by E2F6 (Homo sapiens)
        
        E2F6:TFDP1/2,(E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6) [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6:E2F1 gene [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
        
        PRC1.6 (PCGF6:L3MBTL2:RING1,RNF2:YAF2) [nucleoplasm] (Homo sapiens)
        
        YAF2 [nucleoplasm] (Homo sapiens)
        
        PRC1.6 [nucleoplasm] (Homo sapiens)
        
        RYBP,YAF2 [nucleoplasm] (Homo sapiens)
        
        YAF2 [nucleoplasm] (Homo sapiens)
      - E2F6.com-1 complex binds the E2F1 gene promoter (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
        
        PRC1.6 (PCGF6:L3MBTL2:RING1,RNF2:YAF2) [nucleoplasm] (Homo sapiens)
        
        YAF2 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6:E2F1 gene [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
        
        PRC1.6 (PCGF6:L3MBTL2:RING1,RNF2:YAF2) [nucleoplasm] (Homo sapiens)
        
        YAF2 [nucleoplasm] (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
        
        RUNX1 binds PRC1 complexes (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.5 [nucleoplasm] (Homo sapiens)
        
        RYBP,YAF2 [nucleoplasm] (Homo sapiens)
        
        YAF2 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.5 [nucleoplasm] (Homo sapiens)
        
        RYBP,YAF2 [nucleoplasm] (Homo sapiens)
        
        YAF2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8IY57 YAF2

Gene Names

YAF2

Chain

chain:1-180

Reference Genes

BioGPS Gene:10138 YAF2

COSMIC (genes):YAF2 YAF2

CTD Gene:10138 YAF2

dbSNP Gene:10138 YAF2

ENSEMBL:ENSG00000015153 YAF2

HGNC:17363 YAF2

KEGG Gene (Homo sapiens):10138 YAF2

Monarch:10138 YAF2

NCBI Gene:10138 YAF2

OMIM:607534 YAF2

UCSC:Q8IY57 YAF2

Reference Transcript

Other Identifiers

0006350138

10138

11746464_a_at

11751494_a_at

11751495_x_at

11755707_a_at

11758007_s_at

206238_s_at

2410571

244783_at

2749331

2843729

2974882

3152755

3205762

3223518

3260506

3451265

3451266

3451267

3451268

3451269

3451270

3451271

3451272

3451274

3451275

3451293

3451300

3451301

3451302

3451303

3451305

3451306

3856259

38573_at

4012347

47089_at

60776_at

7962358

817_at

84310_at

A_23_P139825

A_33_P3312030

A_33_P3314161

A_33_P3390456

GE62593

GO:0003674

GO:0003677

GO:0003712

GO:0003713

GO:0003714

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0007049

GO:0008150

GO:0009058

GO:0034641

GO:0043167

GO:0043226

GO:0045892

GO:0045893

GO:0046872

GO:0070317

Hs.136943.0.A1_3p_at

ILMN_1765606

ILMN_2363805

PH_hs_0016781

PH_hs_0039544

TC12001402.hg

TC12002839.hg

U72209_at

g5032228_3p_a_at

Participant Of

hasComponent

PRC1.6 (PCGF6:L3MBTL2:RING1,RNF2:YAF2) [nucleoplasm]

hasMember

RYBP,YAF2 [nucleoplasm]

Inferred To

RYBP [nucleoplasm] (Drosophila melanogaster)

Yaf2 [nucleoplasm] (Mus musculus)

Yaf2 [nucleoplasm] (Rattus norvegicus)

yaf2 [nucleoplasm] (Danio rerio)

yaf2 [nucleoplasm] (Xenopus tropicalis)

YAF2 [nucleoplasm] (Bos taurus)

YAF2 [nucleoplasm] (Canis familiaris)

YAF2 [nucleoplasm] (Gallus gallus)

YAF2 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001177909.1, NP_001177906.1, NP_001177908.1, NP_005739.2

OpenTargets

ENSG00000015153

GeneCards

Q8IY57

HPA

ENSG00000015153-YAF2

Ensembl

ENST00000534854, ENST00000555248, ENSG00000015153, ENSP00000451626, ENSP00000328004, ENST00000327791, ENSP00000439256, ENST00000380790, ENSP00000370167

PRO

Q8IY57

PDB

2D9G

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35227 PCGF2	1	PCGF2 [nucleoplasm] (R-HSA-389115)	0.643	4
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.593	4
UniProt:O75461 E2F6	2	p-S12-E2F6 [nucleoplasm] (R-HSA-9007536) E2F6 [nucleoplasm] (R-HSA-8953089)	0.527	3
UniProt:Q14186 TFDP1	1	TFDP1 [nucleoplasm] (R-HSA-68652)	0.527	2
UniProt:Q9BYE7 PCGF6	1	PCGF6 [nucleoplasm] (R-HSA-8953572)	0.527	3