Reactome | Ub-63-UBB(1-76) [cytosol]

Ub-63-UBB(1-76) [cytosol]

Stable Identifier

R-HSA-939224

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ub-63-UBB, K63 ubiquitin (UBB 1)

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P0CG47 UBB

Gene Names

UBB

Chain

chain:1-76, chain:77-152, chain:153-228, propeptide:-

Reference Genes

BioGPS Gene:7314 UBB

COSMIC (genes):UBB UBB

CTD Gene:7314 UBB

dbSNP Gene:7314 UBB

ENSEMBL:ENSG00000170315 UBB

HGNC:12463 UBB

KEGG Gene (Homo sapiens):7314 UBB

Monarch:7314 UBB

NCBI Gene:7314 UBB

OMIM:191339 UBB

Reference Transcript

Other Identifiers

0006660142

11732126_x_at

11744327_x_at

1323_at

16831434

200633_at

2578171

2578172

2578173

2578174

32153_s_at

3712045

3712046

3712047

3712048

3712050

3712051

3712052

3712053

3712054

3712055

3712056

3714880

3714882

3714883

3714884

3714885

3714889

7314

8005166

A_14_P126655

A_23_P27215

A_24_P113109

GE79998

GO:0000003

GO:0000122

GO:0000187

GO:0000209

GO:0000715

GO:0000717

GO:0000902

GO:0002755

GO:0002756

GO:0003674

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005741

GO:0005768

GO:0005789

GO:0005829

GO:0005886

GO:0006259

GO:0006283

GO:0006294

GO:0006296

GO:0006297

GO:0006464

GO:0006605

GO:0006625

GO:0006810

GO:0006950

GO:0007049

GO:0007141

GO:0007144

GO:0007165

GO:0007179

GO:0007249

GO:0007254

GO:0007267

GO:0008150

GO:0008219

GO:0008584

GO:0008585

GO:0009056

GO:0009058

GO:0010008

GO:0015031

GO:0016055

GO:0016192

GO:0016197

GO:0016567

GO:0016579

GO:0019058

GO:0019068

GO:0019221

GO:0019899

GO:0019941

GO:0019985

GO:0021888

GO:0022607

GO:0030154

GO:0030512

GO:0030666

GO:0030705

GO:0031145

GO:0031386

GO:0031398

GO:0031410

GO:0031625

GO:0031982

GO:0033683

GO:0034641

GO:0034655

GO:0035666

GO:0036297

GO:0042276

GO:0042592

GO:0042769

GO:0043005

GO:0043025

GO:0043065

GO:0043066

GO:0043226

GO:0043488

GO:0043657

GO:0044267

GO:0044403

GO:0045944

GO:0047497

GO:0048812

GO:0048856

GO:0051092

GO:0051276

GO:0051403

GO:0051881

GO:0055085

GO:0060612

GO:0060613

GO:0061024

GO:0061136

GO:0061418

GO:0065003

GO:0070062

GO:0070423

GO:0070498

GO:0070911

GO:0070987

GO:0072520

GO:0075733

GO:0097009

GO:1901214

GO:1902255

GO:1902527

ILMN_1762436

ILMN_2191428

PH_hs_0017263

TC17000187.hg

U49869_rna1_at

g11024713_3p_at

Participant Of

hasMember

K63-Ub [cytosol]

Other forms of this molecule

UBB(77-152) [endocytic vesicle membrane]

UBB(1-76) [endocytic vesicle membrane]

UBB(153-228) [endocytic vesicle membrane]

Ub-33-UBB(1-76) [mitochondrial outer membrane]

Ub-110-UBB(77-152) [mitochondrial outer membrane]

Ub-186-UBB(153-228) [mitochondrial outer membrane]

Ub-215-UBB(153-228) [mitochondrial outer membrane]

Ub-63-UBB(1-76) [mitochondrial outer membrane]

Ub-139-UBB(77-152) [mitochondrial outer membrane]

Ub-158-UBB(153-228) [mitochondrial outer membrane]

Ub-6-UBB(1-76) [mitochondrial outer membrane]

Ub-82-UBB(77-152) [mitochondrial outer membrane]

Ub-163-UBB(153-228) [mitochondrial outer membrane]

Ub-87-UBB(77-152) [mitochondrial outer membrane]

Ub-11-UBB(1-76) [mitochondrial outer membrane]

Ub-124-UBB(77-152) [mitochondrial outer membrane]

Ub-200-UBB(153-228) [mitochondrial outer membrane]

Ub-48-UBB(1-76) [mitochondrial outer membrane]

Ub-182-UBB(153-228) [mitochondrial outer membrane]

Ub-29-UBB(1-76) [mitochondrial outer membrane]

Ub-106-UBB(77-152) [mitochondrial outer membrane]

Ub-27-UBB(1-76) [mitochondrial outer membrane]

Ub-180-UBB(153-228) [mitochondrial outer membrane]

Ub-104-UBB(77-152) [mitochondrial outer membrane]

N6-glycyl-L-lysine-UBB(1-76) [cytosol]

N6-glycyl-L-lysine-UBB(153-228) [cytosol]

N6-glycyl-L-lysine-UBB(77-152) [cytosol]

adenylatedG152-UBB(77-152) [nucleoplasm]

adenylatedG228-UBB(153-228) [nucleoplasm]

adenylatedG76-UBB(1-76) [nucleoplasm]

UBB [cytosol]

adenylatedG76-UBB(1-76) [cytosol]

adenylatedG228-UBB(153-228) [cytosol]

adenylatedG152-UBB(77-152) [cytosol]

Ub-124-UBB(77-152) [endoplasmic reticulum membrane]

Ub-48-UBB(1-76) [endoplasmic reticulum membrane]

Ub-200-UBB(153-228) [endoplasmic reticulum membrane]

UBB(153-228) [plasma membrane]

UBB(1-76) [plasma membrane]

UBB(77-152) [plasma membrane]

UBB(77-152) [endosome membrane]

UBB(1-76) [endosome membrane]

UBB(153-228) [endosome membrane]

UBB(153-228) [endoplasmic reticulum membrane]

UBB(77-152) [endoplasmic reticulum membrane]

UBB(1-76) [endoplasmic reticulum membrane]

Ub-106-UBB(77-152) [cytosol]

Ub-182-UBB(153-228) [cytosol]

Ub-29-UBB(1-76) [cytosol]

Ub-158-UBB(153-228) [cytosol]

Ub-82-UBB(77-152) [cytosol]

Ub-6-UBB(1-76) [cytosol]

Ub-33-UBB(1-76) [cytosol]

Ub-186-UBB(153-228) [cytosol]

Ub-110-UBB(77-152) [cytosol]

Ub-27-UBB(1-76) [cytosol]

Ub-104-UBB(77-152) [cytosol]

Ub-180-UBB(153-228) [cytosol]

Ub-11-UBB(1-76) [cytosol]

Ub-163-UBB(153-228) [cytosol]

Ub-87-UBB(77-152) [cytosol]

Ub-139-UBB(77-152) [endosome membrane]

Ub-215-UBB(153-228) [endosome membrane]

Ub-63-UBB(1-76) [endosome membrane]

Ub-139-UBB(77-152) [plasma membrane]

Ub-63-UBB(1-76) [plasma membrane]

Ub-215-UBB(153-228) [plasma membrane]

Ub-27-UBB(1-76) [nucleoplasm]

Ub-180-UBB(153-228) [nucleoplasm]

Ub-104-UBB(77-152) [nucleoplasm]

Ub-106-UBB(77-152) [nucleoplasm]

Ub-182-UBB(153-228) [nucleoplasm]

Ub-29-UBB(1-76) [nucleoplasm]

Ub-124-UBB(77-152) [nucleoplasm]

Ub-48-UBB(1-76) [nucleoplasm]

Ub-200-UBB(153-228) [nucleoplasm]

Ub-11-UBB(1-76) [nucleoplasm]

Ub-87-UBB(77-152) [nucleoplasm]

Ub-163-UBB(153-228) [nucleoplasm]

Ub-186-UBB(153-228) [nucleoplasm]

Ub-110-UBB(77-152) [nucleoplasm]

Ub-33-UBB(1-76) [nucleoplasm]

UBB(77-152) [nucleoplasm]

UBB(1-76) [nucleoplasm]

UBB(153-228) [nucleoplasm]

Ub-48-UBB(1-76) [nucleoplasm]

Ub-124-UBB(77-152) [nucleoplasm]

Ub-200-UBB(153-228) [nucleoplasm]

Ub-139-UBB(77-152) [nucleoplasm]

Ub-63-UBB(1-76) [nucleoplasm]

Ub-215-UBB(153-228) [nucleoplasm]

Ub-82-UBB(77-152) [nucleoplasm]

Ub-6-UBB(1-76) [nucleoplasm]

Ub-158-UBB(153-228) [nucleoplasm]

UBB(153-228) [late endosome lumen]

UBB(77-152) [late endosome lumen]

UBB(1-76) [late endosome lumen]

Ub-48-UBB(1-76) [cytosol]

Ub-124-UBB(77-152) [cytosol]

Ub-200-UBB(153-228) [cytosol]

UBB(153-228) [cytosol]

UBB(77-152) [cytosol]

UBB(1-76) [cytosol]

UBB(77-152) [lysosomal lumen]

UBB(1-76) [lysosomal lumen]

UBB(153-228) [lysosomal lumen]

Ub-215-UBB(153-228) [cytosol]

Ub-139-UBB(77-152) [cytosol]

Inferred To

Ubc [cytosol] (Mus musculus)

ubqD [cytosol] (Dictyostelium discoideum)

Ub-63-UBB(1-76) [cytosol] (Canis familiaris)

Ub-63-UBB(1-76) [cytosol] (Danio rerio)

Ub-63-UBB(1-76) [cytosol] (Plasmodium falciparum)

Ub-63-UBB(1-76) [cytosol] (Xenopus tropicalis)

ubqH [cytosol] (Dictyostelium discoideum)

Ubb [cytosol] (Rattus norvegicus)

ubqG [cytosol] (Dictyostelium discoideum)

ubqJ [cytosol] (Dictyostelium discoideum)

ubqI [cytosol] (Dictyostelium discoideum)

UBB [cytosol] (Bos taurus)

UBB [cytosol] (Sus scrofa)

Ubi-p63E [cytosol] (Drosophila melanogaster)

Homologues of Ub-63-UBB(1-76) [cytosol] (Dictyostelium discoideum)

ubqF [cytosol] (Dictyostelium discoideum)

Modified Residues

Name

ubiquitinylated lysine at 63

Coordinate

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_061828.1, NP_001268645.1, NP_001268648.1, NP_001268647.1, NP_001268646.1, NP_001268649.1

Target Pathogen

5b2801b3be737e35a6df151a, 5b2801b3be737e35a6df13b3, 5b2801b2be737e35a6de9bef, 5b2801b3be737e35a6df0575

OpenTargets

ENSG00000170315

HPA

ENSG00000170315-UBB

GeneCards

P0CG47

Ensembl

ENSG00000170315, ENST00000395839, ENSP00000379180, ENST00000395837, ENSP00000379178, ENSP00000478771, ENST00000302182, ENSP00000304697, ENST00000614404

PRO

P0CG47

Orphanet

25118

PDB

5VNZ, 5N38, 5O6T, 6ISU, 5CRA, 5GOI, 5IBK, 6UH5, 5VZM, 6MSD, 5GOH, 6FGE, 6QK9, 6HEI, 4ZPZ, 5GJQ, 5GOC, 5OHK, 5O44, 6JB7, 5X3M, 5E6J, 5CVO, 5KYC, 6H4H, 5VF0, 6CP2, 5GOB, 2MBB, 4UEL, 6QF8, 5LRV, 6QML, 5N2W, 5GO8, 6PGV, 5L9T, 5IFR, 6K9P, 6MSE, 4ZFR, 4WUR, 6KOX, 4XOF, 6GZS, 5BNB, 5H7S, 4ZFT, 5V1Z, 6N13, 5TXK, 5KGF, 5MNJ, 4WHV, 6FDK, 5KHY, 5KYF, 5CVN, 5XDP, 6EI1, 5ULK, 5DK8, 5YIJ, 6MSG, 5ULH, 5VZW, 5GOJ, 5ULF, 5VO0, 5CAW, 5GO7, 6FX4, 5JTV, 5LN1, 2MSG, 6HEK, 5TOG, 5L8W, 6KOW, 5X3O, 5YDR, 5TOF, 5GOG, 5X3N, 6GLC, 4ZUX, 6O96, 5WFI, 5YT6, 5VEY, 5GOD, 6JB6, 5JP3, 5EMZ, 5OHN, 5XK5, 5GOK, 5LRX, 5OHP, 5JBY, 5KYE, 6JMA, 5XK4, 5XBO, 5NL5, 5TUT, 6IF1, 6BVA, 5K9P, 2N13, 6NJG, 5DFL, 5UJN, 5ZD0, 6ASR, 6FYH, 5M93, 5UJL, 6BYH, 5EYA, 5JTJ, 5V1Y, 2KHW, 6MSB, 5L8H, 6FTX, 4UF6, 5EDV, 6DGF, 5OHL, 5YMY, 5ZBU, 6C16, 5W46, 5JG6, 6K4I, 5D0K, 5NVG, 4WLR, 5D0M, 2MRO, 5NLJ, 5CVM, 5LRW, 5KYD, 5XPK, 5YIK

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15038 DAZP2			0.742	7
UniProt:O95630 STAMBP	1	STAMBP [cytosol] (R-HSA-5693063)	0.683	4
UniProt:Q9BSL1 UBAC1	1	UBAC1 [cytosol] (R-HSA-8851644)	0.666	4
UniProt:P54727 RAD23B	2	RAD23B [nucleoplasm] (R-HSA-62590) RAD23B [cytosol] (R-HSA-8850589)	0.666	5
UniProt:P0C0S8 H2AC11	11	Ub-HIST1H2AG [nucleoplasm] (R-HSA-6782508) K63polyUb-HIST1H2AG [nucleoplasm] (R-HSA-6783237) Ack6-HIST1H2AG [nucleoplasm] (R-HSA-4568595) Ack-HIST1H2AG [nucleoplasm] (R-HSA-4551311) Me2aR30-HIST1H2AG [nucleoplasm] (R-HSA-5244582) MeR30-HIST1H2AG [nucleoplasm] (R-HSA-5244560) Me2aR4-HIST1H2AG [nucleoplasm] (R-HSA-5244587) MeR4-HIST1H2AG [nucleoplasm] (R-HSA-5244623) Me2aR12-HIST1H2AG [nucleoplasm] (R-HSA-5229305) MeR12-HIST1H2AG [nucleoplasm] (R-HSA-5229206) HIST1H2AG [nucleoplasm] (R-HSA-212084)	0.65	14
UniProt:Q9Y3C5 RNF11			0.647	3
UniProt:Q9UJ41 RABGEF1	2	RABGEF1 [cytosol] (R-HSA-8875419) RABGEF1 [early endosome membrane] (R-HSA-2029032)	0.632	6
UniProt:Q9HAU4 SMURF2	2	SMURF2 [nucleoplasm] (R-HSA-178202) SMURF2 [cytosol] (R-HSA-173537)	0.623	4
UniProt:P46934 NEDD4	1	NEDD4 [cytosol] (R-HSA-975992)	0.59	2
UniProt:Q60592 MAST2			0.589	2
UniProt:Q9UJY5 GGA1	2	GGA1 [endosome membrane] (R-HSA-5692930) GGA1 [early endosome membrane] (R-HSA-8854136)	0.581	3
UniProt:Q13077 TRAF1	3	TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1 [cytosol] (R-HSA-5634163) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.564	2
UniProt:Q9NRQ2 PLS4			0.556	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:Q8N3F0 MTURN			0.556	3
UniProt:Q96CS7 PKHB2			0.556	3
UniProt:O60260-5 PRKN			0.556	6
UniProt:Q96FW1 OTUB1	2	OTUB1 [nucleoplasm] (R-HSA-6783242) OTUB1 [cytosol] (R-HSA-933411)	0.556	3
UniProt:Q6GQQ9-2 Q6GQQ92			0.556	3
UniProt:O75886 STAM2	2	STAM2 [cytosol] (R-HSA-182965) Ub-STAM2 [cytosol] (R-HSA-6782781)	0.556	3
UniProt:Q8NA23-2 Q8NA232			0.556	3
UniProt:Q9H305 CDIP1			0.556	3
UniProt:P45974-2 USP5			0.556	3
UniProt:Q86VP1 TAX1BP1	1	TAX1BP1 [cytosol] (R-HSA-937346)	0.556	3
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.556	3
UniProt:Q6ICB0 DESI1			0.556	3
UniProt:P00441 SOD1	5	2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [extracellular region] (R-HSA-350705) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) SOD1 [cytosol] (R-HSA-350697) 2xHC-SOD1 [cytosol] (R-HSA-3299726)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P28562 DUSP1	1	DUSP1 [nucleoplasm] (R-HSA-203796)	0.544	2
UniProt:Q96CS3 FAF2	2	FAF2 [azurophil granule lumen] (R-HSA-6799138) FAF2 [extracellular region] (R-HSA-6806183)	0.527	3
UniProt:Q9DLK6 Q9DLK6			0.524	2
UniProt:P24610	1	Pax3 [nucleoplasm] (R-MMU-5603237)	0.524	2
UniProt:Q8IVM0 CCD50			0.508	2
UniProt:Q9NZ52 GGA3	3	GGA3 [recycling endosome membrane] (R-HSA-8875655) GGA3 [endosome membrane] (R-HSA-5692936) GGA3 [early endosome membrane] (R-HSA-8854137)	0.508	2
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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