Ub-63-UBB(1-76) [cytosol]

Stable Identifier
R-HSA-939224
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Ub-63-UBB, K63 ubiquitin (UBB 1)
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P0CG47 UBB
Gene Names
UBB
Chain
chain:1-76, chain:77-152, chain:153-228, propeptide:-
Reference Genes
BioGPS Gene:7314 UBB
COSMIC (genes):UBB UBB
CTD Gene:7314 UBB
dbSNP Gene:7314 UBB
ENSEMBL:ENSG00000170315 UBB
HGNC:12463 UBB
KEGG Gene (Homo sapiens):7314 UBB
Monarch:7314 UBB
NCBI Gene:7314 UBB
OMIM:191339 UBB
Reference Transcript
Other Identifiers
0006660142
11732126_x_at
11744327_x_at
1323_at
16831434
200633_at
2578171
2578172
2578173
2578174
32153_s_at
3712045
3712046
3712047
3712048
3712050
3712051
3712052
3712053
3712054
3712055
3712056
3714880
3714882
3714883
3714884
3714885
3714889
7314
8005166
A_14_P126655
A_23_P27215
A_24_P113109
GE79998
GO:0000003
GO:0000122
GO:0000187
GO:0000209
GO:0000278
GO:0000715
GO:0000717
GO:0000902
GO:0002753
GO:0002755
GO:0002756
GO:0003674
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005741
GO:0005768
GO:0005783
GO:0005789
GO:0005829
GO:0005886
GO:0006259
GO:0006283
GO:0006294
GO:0006296
GO:0006297
GO:0006464
GO:0006810
GO:0006914
GO:0006950
GO:0007049
GO:0007096
GO:0007141
GO:0007144
GO:0007165
GO:0007179
GO:0007249
GO:0007254
GO:0007267
GO:0008104
GO:0008150
GO:0008219
GO:0008584
GO:0008585
GO:0009056
GO:0009058
GO:0010008
GO:0016055
GO:0016192
GO:0016197
GO:0016567
GO:0016579
GO:0019058
GO:0019068
GO:0019081
GO:0019221
GO:0019899
GO:0019941
GO:0019985
GO:0021888
GO:0022607
GO:0030154
GO:0030512
GO:0030666
GO:0030705
GO:0031145
GO:0031386
GO:0031398
GO:0031410
GO:0031625
GO:0031982
GO:0033683
GO:0034641
GO:0034655
GO:0035666
GO:0035973
GO:0036297
GO:0036388
GO:0042276
GO:0042592
GO:0042769
GO:0043005
GO:0043025
GO:0043065
GO:0043066
GO:0043226
GO:0043488
GO:0043657
GO:0044322
GO:0044403
GO:0045944
GO:0047497
GO:0048812
GO:0048856
GO:0051092
GO:0051276
GO:0051403
GO:0051881
GO:0052031
GO:0055085
GO:0060612
GO:0060613
GO:0061024
GO:0061136
GO:0061418
GO:0065003
GO:0070062
GO:0070423
GO:0070498
GO:0070911
GO:0070987
GO:0072520
GO:0075733
GO:0097009
GO:0140014
GO:1901214
GO:1902255
GO:1902527
GO:1904380
GO:1990000
HMNXSV003053727
ILMN_1762436
ILMN_2191428
PH_hs_0017263
TC17000187.hg
U49869_rna1_at
g11024713_3p_at
Participates
as a member of
Other forms of this molecule
UBB(77-152) [endocytic vesicle membrane]
UBB(1-76) [endocytic vesicle membrane]
UBB(153-228) [endocytic vesicle membrane]
Ub-33-UBB(1-76) [mitochondrial outer membrane]
Ub-110-UBB(77-152) [mitochondrial outer membrane]
Ub-186-UBB(153-228) [mitochondrial outer membrane]
Ub-215-UBB(153-228) [mitochondrial outer membrane]
Ub-63-UBB(1-76) [mitochondrial outer membrane]
Ub-139-UBB(77-152) [mitochondrial outer membrane]
Ub-158-UBB(153-228) [mitochondrial outer membrane]
Ub-6-UBB(1-76) [mitochondrial outer membrane]
Ub-82-UBB(77-152) [mitochondrial outer membrane]
Ub-163-UBB(153-228) [mitochondrial outer membrane]
Ub-87-UBB(77-152) [mitochondrial outer membrane]
Ub-11-UBB(1-76) [mitochondrial outer membrane]
Ub-124-UBB(77-152) [mitochondrial outer membrane]
Ub-200-UBB(153-228) [mitochondrial outer membrane]
Ub-48-UBB(1-76) [mitochondrial outer membrane]
Ub-182-UBB(153-228) [mitochondrial outer membrane]
Ub-29-UBB(1-76) [mitochondrial outer membrane]
Ub-106-UBB(77-152) [mitochondrial outer membrane]
Ub-27-UBB(1-76) [mitochondrial outer membrane]
Ub-180-UBB(153-228) [mitochondrial outer membrane]
Ub-104-UBB(77-152) [mitochondrial outer membrane]
N6-glycyl-L-lysine-UBB(1-76) [cytosol]
N6-glycyl-L-lysine-UBB(153-228) [cytosol]
N6-glycyl-L-lysine-UBB(77-152) [cytosol]
adenylatedG152-UBB(77-152) [nucleoplasm]
adenylatedG228-UBB(153-228) [nucleoplasm]
adenylatedG76-UBB(1-76) [nucleoplasm]
UBB [cytosol]
adenylatedG76-UBB(1-76) [cytosol]
adenylatedG228-UBB(153-228) [cytosol]
adenylatedG152-UBB(77-152) [cytosol]
Ub-124-UBB(77-152) [endoplasmic reticulum membrane]
Ub-48-UBB(1-76) [endoplasmic reticulum membrane]
Ub-200-UBB(153-228) [endoplasmic reticulum membrane]
UBB(153-228) [plasma membrane]
UBB(1-76) [plasma membrane]
UBB(77-152) [plasma membrane]
UBB(77-152) [endosome membrane]
UBB(1-76) [endosome membrane]
UBB(153-228) [endosome membrane]
UBB(153-228) [endoplasmic reticulum membrane]
UBB(77-152) [endoplasmic reticulum membrane]
UBB(1-76) [endoplasmic reticulum membrane]
Ub-106-UBB(77-152) [cytosol]
Ub-182-UBB(153-228) [cytosol]
Ub-29-UBB(1-76) [cytosol]
Ub-158-UBB(153-228) [cytosol]
Ub-82-UBB(77-152) [cytosol]
Ub-6-UBB(1-76) [cytosol]
Ub-33-UBB(1-76) [cytosol]
Ub-186-UBB(153-228) [cytosol]
Ub-110-UBB(77-152) [cytosol]
Ub-27-UBB(1-76) [cytosol]
Ub-104-UBB(77-152) [cytosol]
Ub-180-UBB(153-228) [cytosol]
Ub-11-UBB(1-76) [cytosol]
Ub-163-UBB(153-228) [cytosol]
Ub-87-UBB(77-152) [cytosol]
Ub-139-UBB(77-152) [endosome membrane]
Ub-215-UBB(153-228) [endosome membrane]
Ub-63-UBB(1-76) [endosome membrane]
Ub-139-UBB(77-152) [plasma membrane]
Ub-63-UBB(1-76) [plasma membrane]
Ub-215-UBB(153-228) [plasma membrane]
Ub-27-UBB(1-76) [nucleoplasm]
Ub-180-UBB(153-228) [nucleoplasm]
Ub-104-UBB(77-152) [nucleoplasm]
Ub-106-UBB(77-152) [nucleoplasm]
Ub-182-UBB(153-228) [nucleoplasm]
Ub-29-UBB(1-76) [nucleoplasm]
Ub-124-UBB(77-152) [nucleoplasm]
Ub-48-UBB(1-76) [nucleoplasm]
Ub-200-UBB(153-228) [nucleoplasm]
Ub-11-UBB(1-76) [nucleoplasm]
Ub-87-UBB(77-152) [nucleoplasm]
Ub-163-UBB(153-228) [nucleoplasm]
Ub-186-UBB(153-228) [nucleoplasm]
Ub-110-UBB(77-152) [nucleoplasm]
Ub-33-UBB(1-76) [nucleoplasm]
Ub-48-UBB(1-76) [nucleoplasm]
Ub-124-UBB(77-152) [nucleoplasm]
Ub-200-UBB(153-228) [nucleoplasm]
UBB(77-152) [nucleoplasm]
UBB(1-76) [nucleoplasm]
UBB(153-228) [nucleoplasm]
Ub-139-UBB(77-152) [nucleoplasm]
Ub-63-UBB(1-76) [nucleoplasm]
Ub-215-UBB(153-228) [nucleoplasm]
Ub-82-UBB(77-152) [nucleoplasm]
Ub-6-UBB(1-76) [nucleoplasm]
Ub-158-UBB(153-228) [nucleoplasm]
UBB(153-228) [late endosome lumen]
UBB(77-152) [late endosome lumen]
UBB(1-76) [late endosome lumen]
Ub-48-UBB(1-76) [cytosol]
Ub-124-UBB(77-152) [cytosol]
Ub-200-UBB(153-228) [cytosol]
UBB(153-228) [cytosol]
UBB(77-152) [cytosol]
UBB(1-76) [cytosol]
UBB(77-152) [lysosomal lumen]
UBB(1-76) [lysosomal lumen]
UBB(153-228) [lysosomal lumen]
Ub-215-UBB(153-228) [cytosol]
Ub-139-UBB(77-152) [cytosol]
Inferred To
RPL40B [cytosol] (Saccharomyces cerevisiae)
ubqD [cytosol] (Dictyostelium discoideum)
RPS31 [cytosol] (Saccharomyces cerevisiae)
ubqB [cytosol] (Dictyostelium discoideum)
ubqJ [cytosol] (Dictyostelium discoideum)
rps27a [cytosol] (Danio rerio)
rps27a [cytosol] (Xenopus tropicalis)
Homologues of Ub-63-RPS27A(1-76) [cytosol] (Dictyostelium discoideum)
Homologues of Ub-63-RPS27A(1-76) [cytosol] (Saccharomyces cerevisiae)
Homologues of Ub-63-RPS27A(1-76) [cytosol] (Schizosaccharomyces pombe)
ubqI [cytosol] (Dictyostelium discoideum)
Rps27a [cytosol] (Mus musculus)
Rps27a [cytosol] (Rattus norvegicus)
ubi3 [cytosol] (Schizosaccharomyces pombe)
ubqC [cytosol] (Dictyostelium discoideum)
nedd8l1 [cytosol] (Dictyostelium discoideum)
K63-ubiquitin (RPS27A) [cytosol] (Gallus gallus)
RPS27A [cytosol] (Sus scrofa)
ubqH [cytosol] (Dictyostelium discoideum)
uep1 [cytosol] (Schizosaccharomyces pombe)
ubi5 [cytosol] (Schizosaccharomyces pombe)
ubqG [cytosol] (Dictyostelium discoideum)
ubi1 [cytosol] (Schizosaccharomyces pombe)
ubqA [cytosol] (Dictyostelium discoideum)
RPL40A [cytosol] (Saccharomyces cerevisiae)
UBB [cytosol] (Canis familiaris)
RpS27A [cytosol] (Drosophila melanogaster)
ubqF [cytosol] (Dictyostelium discoideum)
Modified Residues
Name
ubiquitinylated lysine at 63
Coordinate
63
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
OpenTargets
GeneCards
HPA
Ensembl
PRO
Pharos - Targets
GlyGen
Orphanet
PDB
5XPK, 6IF1, 4XOF, 6C16, 6MSG, 5GOH, 5H7S, 5ULH, 4ZFT, 5DFL, 5GOI, 2KHW, 5M93, 5YMY, 6DGF, 5O6T, 5IBK, 2N13, 6MSE, 6JB6, 5IFR, 5LRW, 5X3N, 6K4I, 5V1Z, 5X3O, 5VO0, 6QF8, 5KGF, 5LRX, 2MSG, 5TOG, 5K9P, 5JTV, 6FX4, 6TBM, 6BVA, 5VNZ, 4ZPZ, 5XBO, 6HEK, 7CAP, 5JP3, 6CP2, 5CAW, 5CRA, 2MRO, 6OAM, 5WFI, 6NJG, 6EI1, 6ISU, 5ZBU, 5O44, 4WHV, 4WLR, 5GOC, 5DK8, 4ZUX, 5GOB, 5JTJ, 5OHK, 5KYD, 5UJN, 5N38, 6ASR, 5JBY, 5TOF, 5JG6, 6FGE, 5KYE, 6N13, 4UF6, 6BYH, 5GOG, 6KOX, 5W46, 6K9P, 5GJQ, 5VZW, 5BNB, 5XDP, 6KOW, 6MSD, 5YIK, 5VEY, 5GO8, 5GO7, 5TXK, 5L8H, 5GOJ, 6FDK, 6QK9, 5NVG, 5VF0, 5X3M, 5CVM, 5LRV, 5CVN, 5D0M, 5YDR, 6FYH, 5YIJ, 6GZS, 5E6J, 6JB7, 5ZD0, 5GOD, 5ULF, 4ZFR, 4WUR, 6PGV, 5XK4, 6LP2, 5ULK, 5EYA, 5OHN, 5XK5, 5L9T, 5OHL, 5KYF, 6QML, 5OHP, 5V1Y, 5EMZ, 5YT6, 6JMA, 5D0K, 2MBB, 5NLJ, 5GOK, 5KHY, 4UEL, 6H4H, 6FTX, 5N2W, 5L8W, 6UH5, 6XAA, 5KYC, 5MNJ, 6MSB, 5CVO, 7JMS, 5TUT, 6PZV, 6HEI, 5NL5, 5UJL, 6GLC, 5LN1, 5VZM, 5EDV, 6O96
Interactors (36)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q15038 DAZP2      0.742 7
 UniProt:O95630 STAMBP  1 0.683 4
 UniProt:Q9BSL1 UBAC1  1 0.666 4
 UniProt:P54727 RAD23B  2 0.666 5
 UniProt:P0C0S8 H2AC11  11 0.65 14
 UniProt:Q9Y3C5 RNF11      0.647 3
 UniProt:Q9UJ41 RABGEF1  2 0.632 6
 UniProt:Q9HAU4 SMURF2  2 0.623 4
 UniProt:P46934 NEDD4  1 0.59 2
 UniProt:Q60592 MAST2      0.589 2
 UniProt:Q9UJY5 GGA1  2 0.581 3
 UniProt:Q13077 TRAF1  3 0.564 2
 UniProt:Q9NRQ2 PLS4      0.556 3
 UniProt:Q9UHD9 UBQLN2  1 0.556 3
 UniProt:Q8N3F0 MTURN      0.556 3
 UniProt:Q96CS7 PKHB2      0.556 3
 UniProt:O60260-5 PRKN      0.556 6
 UniProt:Q96FW1 OTUB1  2 0.556 3
 UniProt:Q6GQQ9-2 Q6GQQ92      0.556 3
 UniProt:O75886 STAM2  2 0.556 3
 UniProt:Q8NA23-2 Q8NA232      0.556 3
 UniProt:Q9H305 CDIP1      0.556 3
 UniProt:P45974-2 USP5      0.556 3
 UniProt:Q86VP1 TAX1BP1  1 0.556 3
 UniProt:Q8N488 RYBP  1 0.556 3
 UniProt:Q6ICB0 DESI1      0.556 3
 UniProt:O00560 SDCBP  3 0.556 3
 UniProt:P05067 APP  20 0.556 3
 UniProt:P00441 SOD1  5 0.556 3
 UniProt:P28562 DUSP1  1 0.544 2
 UniProt:Q96CS3 FAF2  3 0.527 3
 UniProt:Q9DLK6 Q9DLK6      0.524 2
 UniProt:P24610  1 0.524 2
 UniProt:Q9NZ52 GGA3  3 0.508 2
 UniProt:Q8IVM0 CCD50      0.508 2
 UniProt:P03372 ESR1  8 0.462 2
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