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SMURF2 [cytosol]
Stable Identifier
R-HSA-173537
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Homo sapiens)
USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Homo sapiens)
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Homo sapiens)
SMAD7:SMURF2:TGFBR1 [plasma membrane] (Homo sapiens)
SMAD7:SMURF2 [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Homo sapiens)
Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Homo sapiens)
SMAD7:SMURF2:Ub-TGFBR1 [plasma membrane] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
SMURF1/2 bind PTCH1 (Homo sapiens)
PTCH1:SMURF [ciliary membrane] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
SMURF1/2 dissociates from ub-PTCH1 (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
ub-PTCH1:SMURF [ciliary membrane] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
SMURF1/2 ubiquitinates PTCH1 (Homo sapiens)
PTCH1:SMURF [ciliary membrane] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
ub-PTCH1:SMURF [ciliary membrane] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by BMP (Homo sapiens)
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Homo sapiens)
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Homo sapiens)
I-SMAD:SMURF [cytosol] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
I-SMAD:SMURF [cytosol] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
SMAD7:SMURF complex binds to phosphorylated TGFBR1 (Homo sapiens)
SMAD7:SMURF/NEDD4L [cytosol] (Homo sapiens)
SMURF/NEDD4L [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1:SMAD7:SMURF/NEDD4L [plasma membrane] (Homo sapiens)
SMAD7:SMURF/NEDD4L [cytosol] (Homo sapiens)
SMURF/NEDD4L [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
SMAD7:SMURF2 complex translocates to the cytosol (Homo sapiens)
SMAD7:SMURF2 [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
SMURF2 binds SMAD2 (Homo sapiens)
SMAD2:SMURF2 [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
SMURF2 ubiquitinates SMAD2 (Homo sapiens)
SMAD2:SMURF2 [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
SMURF/NEDD4L [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1:SMAD7:SMURF/NEDD4L [plasma membrane] (Homo sapiens)
SMAD7:SMURF/NEDD4L [cytosol] (Homo sapiens)
SMURF/NEDD4L [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
Asymmetric localization of PCP proteins (Homo sapiens)
SMURF1/2 are recruited to the DVL2:PARD6A complex (Homo sapiens)
PARD6A:pp-DVL2:SMURF [plasma membrane] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
SMURF1/2 ubiquitinates PRICKLE1 (Homo sapiens)
PARD6A:pp-DVL2:SMURF [plasma membrane] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Degradation of AXIN (Homo sapiens)
AXIN is ubiquitinated by SMURF2 (Homo sapiens)
AXIN:SMURF2 [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
ub-AXIN:SMURF2 [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
SMURF2 binds AXIN (Homo sapiens)
AXIN:SMURF2 [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
Ubiquitinated AXIN is degraded by the proteasome (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
ub-AXIN:SMURF2 [cytosol] (Homo sapiens)
SMURF2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9HAU4 SMURF2
Gene Names
SMURF2
Chain
chain:1-748
Reference Genes
BioGPS Gene:64750 SMURF2
COSMIC (genes):SMURF2 SMURF2
CTD Gene:64750 SMURF2
dbSNP Gene:64750 SMURF2
ENSEMBL:ENSG00000108854 SMURF2
ENSEMBL_homo_sapiens_GENE:ENSG00000108854.16 SMURF2
HGNC:16809 SMURF2
KEGG Gene (Homo sapiens):64750 SMURF2
Monarch:64750 SMURF2
NCBI Gene:64750 SMURF2
OMIM:605532 SMURF2
UCSC:Q9HAU4 SMURF2
Reference Transcript
RefSeq:NM_022739.3 SMURF2
Other Identifiers
11723820_a_at
11723821_a_at
11748382_a_at
16847841
17121638
205596_PM_s_at
205596_s_at
227489_PM_at
227489_at
232020_3p_at
232020_PM_at
232020_at
33354_at
3716598
3717021
3717022
3732647
3766961
3766962
3766963
3766965
3766968
3766972
3766973
3766974
3766975
3766976
3766977
3766979
3766983
3766986
3766989
3766991
3766997
3767002
3767006
3767008
3767026
3767027
3767028
4040318
4040630
58405_at
64750
65451_i_at
8017651
91240_at
A_23_P100754
A_24_P210888
A_33_P3370751
GE82713
GE88328
GO:0000122
GO:0000151
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006511
GO:0016020
GO:0016567
GO:0016607
GO:0016740
GO:0017015
GO:0022414
GO:0023052
GO:0030163
GO:0030512
GO:0030514
GO:0036211
GO:0042802
GO:0043161
GO:0043226
GO:0045121
GO:0045892
GO:0046332
GO:0048856
GO:0048870
GO:0060071
GO:0061630
GO:0090263
GO:0140096
GO:1901165
HMNXSV003009869
Hs.169872.0.A1_3p_at
Hs.323849.0.S1_3p_x_at
ILMN_1675429
PH_hs_0025712
TC17001803.hg
g12408118_3p_at
Participates
as a component of
SMAD7:SMURF2:Ub-TGFBR1 [plasma membrane] (Homo sapiens)
ub-AXIN:SMURF2 [cytosol] (Homo sapiens)
AXIN:SMURF2 [cytosol] (Homo sapiens)
Smad7:SMURF2 [cytosol] (Homo sapiens)
SMAD7:SMURF2 [cytosol] (Homo sapiens)
SMAD2:SMURF2 [cytosol] (Homo sapiens)
as an output of
Ubiquitinated AXIN is degraded by the proteasome (Homo sapiens)
SMURF2 ubiquitinates Smad7 and phosphorylated TGFBR1 (Homo sapiens)
SMURF2 ubiquitinates SMAD2 (Homo sapiens)
as an input of
SMURF2 binds AXIN (Homo sapiens)
SMURF2 binds SMAD2 (Homo sapiens)
as a member of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF/NEDD4L [cytosol] (Homo sapiens)
Other forms of this molecule
SMURF2 [nucleoplasm]
Inferred To
Smurf2 [cytosol]
(Mus musculus)
Smurf2 [cytosol]
(Rattus norvegicus)
pub1 [cytosol]
(Schizosaccharomyces pombe)
RSP5 [cytosol]
(Saccharomyces cerevisiae)
Smurf [cytosol]
(Drosophila melanogaster)
smurf2 [cytosol]
(Danio rerio)
smurf2 [cytosol]
(Xenopus tropicalis)
pub3 [cytosol]
(Schizosaccharomyces pombe)
Homologues of SMURF2 [cytosol]
(Dictyostelium discoideum)
Homologues of SMURF2 [cytosol]
(Schizosaccharomyces pombe)
SMURF2 [cytosol]
(Bos taurus)
SMURF2 [cytosol]
(Canis familiaris)
SMURF2 [cytosol]
(Dictyostelium discoideum)
SMURF2 [cytosol]
(Gallus gallus)
SMURF2 [cytosol]
(Plasmodium falciparum)
SMURF2 [cytosol]
(Sus scrofa)
pub2 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_073576.1
OpenTargets
ENSG00000108854
GeneCards
Q9HAU4
HPA
ENSG00000108854-SMURF2
Ensembl
ENST00000262435
,
ENSP00000262435
,
ENSG00000108854
PRO
Q9HAU4
Pharos - Targets
Q9HAU4
PDB
1ZVD
,
7M3Q
,
2JQZ
,
2DJY
,
6FX4
,
2KXQ
,
2LTZ
HMDB Protein
HMDBP09306
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15797 SMAD1
4
Ub-SMAD1 [cytosol]
(R-HSA-6782768)
SMAD1 [cytosol]
(R-HSA-201468)
p-S463,S465-SMAD1 [cytosol]
(R-HSA-201464)
p-S463,S465-SMAD1 [nucleoplasm]
(R-HSA-201483)
0.855
7
UniProt:Q15796 SMAD2
20
Ub-SMAD2 [cytosol]
(R-HSA-6782774)
p-S465,S467-SMAD2 P305L [cytosol]
(R-HSA-3315471)
p-S465,S467-SMAD2 D300A [cytosol]
(R-HSA-3315064)
p-S465,S467-SMAD2 D300N [cytosol]
(R-HSA-3315066)
p-S465,S467-SMAD2 A354T [cytosol]
(R-HSA-3315474)
p-S465,S467-SMAD2 P305Q [cytosol]
(R-HSA-3315070)
p-S465,S467-SMAD2 D300V [cytosol]
(R-HSA-3315067)
SMAD2 S464* [cytosol]
(R-HSA-3304362)
SMAD2 W422* [cytosol]
(R-HSA-9668736)
SMAD2 S308* [cytosol]
(R-HSA-9668732)
SMAD2 R427* [cytosol]
(R-HSA-9668733)
SMAD2 W448* [cytosol]
(R-HSA-9668734)
SMAD2 S464L [cytosol]
(R-HSA-3304383)
SMAD2 C463* [cytosol]
(R-HSA-9668735)
SMAD2 R321* [cytosol]
(R-HSA-9668728)
SMAD2 S296* [cytosol]
(R-HSA-9668729)
SMAD2 S306* [cytosol]
(R-HSA-9668730)
SMAD2 Q455* [cytosol]
(R-HSA-9668731)
SMAD2 E439* [cytosol]
(R-HSA-9668724)
SMAD2 L315* [cytosol]
(R-HSA-9668725)
0.811
6
UniProt:O15105 SMAD7
2
SMAD7 [nucleoplasm]
(R-HSA-178197)
SMAD7 [cytosol]
(R-HSA-173478)
0.801
7
UniProt:P84022 SMAD3
20
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 [nucleoplasm]
(R-HSA-206150)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
0.799
8
UniProt:Q9Y3C5 RNF11
0.737
5
UniProt:Q9HAU4 SMURF2
2
SMURF2 [nucleoplasm]
(R-HSA-178202)
SMURF2 [cytosol]
(R-HSA-173537)
0.709
6
UniProt:Q99717 SMAD5
3
SMAD5 [cytosol]
(R-HSA-201431)
p-S463,S465-SMAD5 [nucleoplasm]
(R-HSA-201432)
p-S463,S465-SMAD5 [cytosol]
(R-HSA-201473)
0.659
3
UniProt:P0CG47 UBB
20
UBB(77-152) [endocytic vesicle membrane]
(R-HSA-939253)
UBB(1-76) [endocytic vesicle membrane]
(R-HSA-939231)
UBB(153-228) [endocytic vesicle membrane]
(R-HSA-939171)
Ub-33-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783023)
Ub-109-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783008)
Ub-185-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783046)
Ub-215-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783002)
Ub-63-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783148)
Ub-139-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783012)
Ub-158-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783162)
Ub-6-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783014)
Ub-82-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783015)
Ub-163-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783025)
Ub-87-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6782998)
Ub-11-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783109)
Ub-124-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783131)
Ub-200-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783100)
Ub-48-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783165)
Ub-181-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783160)
Ub-29-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783070)
0.623
4
UniProt:Q9H469 FBXL15
1
FBXL15 [cytosol]
(R-HSA-8862625)
0.602
3
UniProt:P46934-4 NEDD4
0.59
2
UniProt:Q15038 DAZP2
0.573
2
UniProt:Q8WWV3 RT4I1
0.556
3
UniProt:Q13017 ARHGAP5
1
ARHGAP5 [cytosol]
(R-HSA-195084)
0.547
2
UniProt:Q9NWM3 CUED1
0.547
2
UniProt:Q7L985 LIGO2
0.527
2
UniProt:Q02383 SEMG2
0.527
2
UniProt:Q96GW9 MARS2
1
MARS2 [mitochondrial matrix]
(R-HSA-379555)
0.527
2
UniProt:Q9WMX2-PRO_0000037548
0.508
2
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