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COMMD8 [nucleoplasm]
Stable Identifier
R-HSA-8955102
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
COMM domain-containing protein 8, COMD8_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs [nucleoplasm] (Homo sapiens)
COMMD8 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs [nucleoplasm] (Homo sapiens)
COMMD8 [nucleoplasm] (Homo sapiens)
COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Homo sapiens)
COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs [nucleoplasm] (Homo sapiens)
COMMD8 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs [nucleoplasm] (Homo sapiens)
COMMD8 [nucleoplasm] (Homo sapiens)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs [nucleoplasm] (Homo sapiens)
COMMD8 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs [nucleoplasm] (Homo sapiens)
COMMD8 [nucleoplasm] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs [nucleoplasm] (Homo sapiens)
COMMD8 [nucleoplasm] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs [nucleoplasm] (Homo sapiens)
COMMD8 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NX08 COMMD8
Gene Names
COMMD8, MDS022
Chain
chain:1-183
Reference Genes
BioGPS Gene:54951 COMMD8
COSMIC (genes):COMMD8 COMMD8
CTD Gene:54951 COMMD8
dbSNP Gene:54951 COMMD8
ENSEMBL:ENSG00000169019 COMMD8
HGNC:26036 COMMD8
KEGG:hsa:54951 COMMD8
Monarch:54951 COMMD8
NCBI Gene:54951 COMMD8
OMIM:616656 COMMD8
UCSC:Q9NX08 COMMD8
Reference Transcript
RefSeq:NM_017845.4 COMMD8
RefSeq:NM_001329668.1 COMMD8
Other Identifiers
11720069_s_at
16975659
218351_PM_at
218351_at
2768158
2768159
2768160
2768163
2768165
2768166
2768167
2768168
2768170
2768171
2768172
54951
65809_at
8100145
A_23_P44257
A_33_P3285077
GE55527
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0043226
HMNXSV003050312
ILMN_1765644
ILMN_2210713
PH_hs_0002109
TC04001167.hg
g8923457_3p_at
Participates
as a candidate of
COMMDs [nucleoplasm] (Homo sapiens)
Other forms of this molecule
COMMD8 [cytosol]
Inferred To
commd8 [nucleoplasm]
(Danio rerio)
commd8 [nucleoplasm]
(Dictyostelium discoideum)
COMMD8 [nucleoplasm]
(Bos taurus)
COMMD8 [nucleoplasm]
(Canis familiaris)
COMMD8 [nucleoplasm]
(Gallus gallus)
COMMD8 [nucleoplasm]
(Sus scrofa)
Commd8 [nucleoplasm]
(Mus musculus)
Commd8 [nucleoplasm]
(Rattus norvegicus)
Cross References
ENSEMBL
ENSP00000370984
,
ENST00000381571
OpenTargets
ENSG00000169019
HPA
ENSG00000169019-COMMD8
PRO
Q9NX08
Pharos - Targets
Q9NX08
PDB
8P0W
,
8F2R
,
8F2U
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14186 TFDP1
1
TFDP1 [nucleoplasm]
(R-HSA-68652)
0.643
4
UniProt:O75461 E2F6
2
E2F6 [nucleoplasm]
(R-HSA-8953089)
p-S12-E2F6 [nucleoplasm]
(R-HSA-9007536)
0.643
4
UniProt:Q14188 TFDP2
1
TFDP2 [nucleoplasm]
(R-HSA-1362225)
0.527
2
UniProt:P0CG47 UBB
20
UBB(77-152) [endocytic vesicle membrane]
(R-HSA-939253)
UBB(1-76) [endocytic vesicle membrane]
(R-HSA-939231)
UBB(153-228) [endocytic vesicle membrane]
(R-HSA-939171)
Ub-33-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783023)
Ub-109-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783008)
Ub-185-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783046)
Ub-215-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783002)
Ub-63-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783148)
Ub-139-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783012)
Ub-158-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783162)
Ub-6-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783014)
Ub-82-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783015)
Ub-163-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783025)
Ub-87-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6782998)
Ub-11-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783109)
Ub-124-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783131)
Ub-200-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783100)
Ub-48-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783165)
Ub-181-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783160)
Ub-29-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783070)
0.527
2
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