Reactome | FANCG [cytosol]

FANCG [cytosol]

Stable Identifier

R-HSA-420788

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Fanconi anemia group G protein, FANCG_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Interferon Signaling (Homo sapiens)
    - Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
      - PKR-mediated signaling (Homo sapiens)
        
        FA core complex:HSP70s binds PKR (Homo sapiens)
        
        FA Core Complex:HSP70s [cytosol] (Homo sapiens)
        
        FA Core Complex [cytosol] (Homo sapiens)
        
        FANCG [cytosol] (Homo sapiens)
        
        FA Core Complex:HSP70s:EIF2AK2 [cytosol] (Homo sapiens)
        
        FA Core Complex:HSP70s [cytosol] (Homo sapiens)
        
        FA Core Complex [cytosol] (Homo sapiens)
        
        FANCG [cytosol] (Homo sapiens)
        
        PKR forms a dimer (Homo sapiens)
        
        FA Core Complex:HSP70s:EIF2AK2 [cytosol] (Homo sapiens)
        
        FA Core Complex:HSP70s [cytosol] (Homo sapiens)
        
        FA Core Complex [cytosol] (Homo sapiens)
        
        FANCG [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O15287 FANCG

Gene Names

FANCG, XRCC9

Chain

chain:1-622

Reference Genes

BioGPS Gene:2189 FANCG

COSMIC (genes):FANCG FANCG

CTD Gene:2189 FANCG

dbSNP Gene:2189 FANCG

ENSEMBL:ENSG00000221829 FANCG

ENSEMBL_homo_sapiens_GENE:ENSG00000221829.11 FANCG

HGNC:3588 FANCG

KEGG Gene (Homo sapiens):2189 FANCG

Monarch:2189 FANCG

NCBI Gene:2189 FANCG

OMIM:602956 FANCG

Reference Transcript

RefSeq:NM_004629.1 FANCG

Other Identifiers

11756256_a_at

17093595

203564_PM_at

203564_at

2189

3204120

3204464

3204465

3204467

3204468

3204469

3204472

3204475

3204476

3204477

3204478

3204479

3204480

3204482

3204483

3204485

3204486

3204487

3204488

3204489

3204490

3204492

3204493

3204494

3204495

37584_at

8160935

A_23_P71644

GE55181

GO:0000785

GO:0001541

GO:0003677

GO:0003684

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005739

GO:0005829

GO:0005886

GO:0006281

GO:0006974

GO:0007005

GO:0007286

GO:0009314

GO:0022414

GO:0030154

GO:0036297

GO:0043226

GO:0043240

GO:0048856

HMNXSV003030302

ILMN_1758728

PH_hs_0025352

TC09001049.hg

g4759335_3p_at

Participates

as a component of

FA Core Complex [cytosol] (Homo sapiens)

Other forms of this molecule

FANCG [nucleoplasm]

Inferred To

FANCG [cytosol] (Bos taurus)

FANCG [cytosol] (Canis familiaris)

FANCG [cytosol] (Gallus gallus)

FANCG [cytosol] (Sus scrofa)

fancg [cytosol] (Xenopus tropicalis)

Fancg [cytosol] (Mus musculus)

Fancg [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_004620.1

OpenTargets

ENSG00000221829

GeneCards

O15287

HPA

ENSG00000221829-FANCG

Ensembl

ENSP00000367910, ENST00000448890, ENSP00000409607, ENSG00000221829, ENST00000378643

PRO

O15287

Pharos - Targets

O15287

Orphanet

16026

PDB

7KZT, 7KZP, 7KZR, 7KZS, 7KZQ, 7KZV

Interactors (55)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15360 FANCA	2	FANCA [nucleoplasm] (R-HSA-419541) FANCA [cytosol] (R-HSA-420796)	0.961	26
UniProt:Q9NPI8 FANCF	2	FANCF [cytosol] (R-HSA-420794) FANCF [nucleoplasm] (R-HSA-419537)	0.75	6
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:Q99633 PRPF18	1	PRPF18 [nucleoplasm] (R-HSA-5688093)	0.556	3
UniProt:Q8TD31-3 CCHCR1			0.556	3
UniProt:P51687 SUOX	1	SUOX [mitochondrial matrix] (R-HSA-1614570)	0.556	3
UniProt:Q9BVL2 NUP58			0.556	3
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:Q86UD4 ZN329			0.556	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:Q13393 PLD1	4	PLD1 [specific granule membrane] (R-HSA-6799531) PLD1 [tertiary granule membrane] (R-HSA-6800955) PLD1 [plasma membrane] (R-HSA-2028998) PLD1 [endoplasmic reticulum membrane] (R-HSA-1498795)	0.556	3
UniProt:P29474 NOS3	7	2xPalmC-MyrG-NOS3 [endocytic vesicle membrane] (R-HSA-535007) NOS3 [cytosol] (R-HSA-202114) MyrG-NOS3 [Golgi membrane] (R-HSA-534995) MyrG-NOS3 [cytosol] (R-HSA-203687) 2xPalmC-MyrG-NOS3 [Golgi membrane] (R-HSA-203769) 2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (R-HSA-202139) 2xPalmC-MyrG-NOS3 [plasma membrane] (R-HSA-534993)	0.556	3
UniProt:Q53GS7 GLE1	1	GLE1 [nucleoplasm] (R-HSA-8932905)	0.556	3
UniProt:P16284 PECAM1	4	PECAM1 [plasma membrane] (R-HSA-114686) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) PECAM1 [secretory granule membrane] (R-HSA-6804778) PECAM1 [platelet alpha granule membrane] (R-HSA-61489)	0.556	3
UniProt:P20339 RAB5A	7	GGC-RAB5A [clathrin-coated endocytic vesicle membrane] (R-HSA-8871125) GGC-RAB5A [early endosome membrane] (R-HSA-8875323) GGC-RAB5A [cytosol] (R-HSA-8870432) RAB5A [early endosome membrane] (R-HSA-2130175) RAB5A [cytosol] (R-HSA-2201187) GGC-RAB5A [macropinosome membrane] (R-HSA-9837697) RAB5A [endosome membrane] (R-HSA-452257)	0.556	3
UniProt:Q92870-2 Q928702			0.556	3
UniProt:O14901 KLF11			0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3
UniProt:P14079 TAX			0.556	3
UniProt:P60891 PRPS1	1	PRPS1 [cytosol] (R-HSA-73483)	0.556	3
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:Q8N8B7-2 TCEANC			0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:Q8N7U7-2 TPRX1			0.556	3
UniProt:P08684 CYP3A4	1	CYP3A4 [endoplasmic reticulum membrane] (R-HSA-52639)	0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q8N6Y0 USBP1			0.553	2
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.553	2
UniProt:P08727 KRT19	1	KRT19 [cytosol] (R-HSA-6809617)	0.553	2
UniProt:P16444 DPEP1	1	DPEP1 [plasma membrane] (R-HSA-2142820)	0.527	3
UniProt:P32970 CD70	1	CD70 [plasma membrane] (R-HSA-5667139)	0.527	3
UniProt:Q9H0L4 CSTF2T	1	CSTF2T [nucleoplasm] (R-HSA-8938786)	0.527	2
UniProt:O43252 PAPSS1	3	PAPSS1 [cytosol] (R-HSA-174387) PAPSS1(1-223)-BRAF(381-766) fusion [cytosol] (R-HSA-6802432) PAPSS1(1-223)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802543)	0.527	2
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.527	2
UniProt:P06028 GYPB	1	GYPB [plasma membrane] (R-HSA-8867209)	0.527	2
UniProt:Q13813 SPTAN1	6	SPTAN1 [cytosol] (R-HSA-201601) SPTAN1(1-1185) [cytosol] (R-HSA-202944) SPTAN1(1186-2472) [cytosol] (R-HSA-202964) SPTAN1 [specific granule lumen] (R-HSA-6799533) SPTAN1 [extracellular region] (R-HSA-6806322) SPTAN1 [tertiary granule lumen] (R-HSA-6800874)	0.508	4
UniProt:P15976-2 GATA1			0.488	2
UniProt:Q8IYA8 IHO1			0.488	2
UniProt:O15360-3 O153603			0.488	5
UniProt:Q6NUQ1 RINT1	1	RINT1 [cytosol] (R-HSA-6810991)	0.488	2
UniProt:P13646 KRT13	1	KRT13 [cytosol] (R-HSA-6809591)	0.488	2
UniProt:Q08117-2 TLE5			0.488	2
UniProt:Q9Y2V7 COG6	2	COG6 [trans-Golgi network membrane] (R-HSA-6813872) COG6 [Golgi membrane] (R-HSA-2980958)	0.488	2
UniProt:Q7Z6G3-2 NECAB2			0.488	2
UniProt:Q8NA61-2 CBY2			0.488	2
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.488	2
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.488	2
UniProt:Q9Y2K1 ZBTB1			0.488	2
UniProt:Q9UKT9 IKZF3			0.488	2
IntAct:EBI-11742485 SSX2IP			0.488	2
UniProt:Q8N448 LNX2			0.488	2

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