Reactome | MeR12-HIST1H2AG [nucleoplasm]

MeR12-HIST1H2AG [nucleoplasm]

Stable Identifier

R-HSA-5229206

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

HIST1H2AG, Histone H2A.1

Locations in the PathwayBrowser

Expand all

Chromatin organization (Homo sapiens)

- Chromatin modifying enzymes (Homo sapiens)
  - RMTs methylate histone arginines (Homo sapiens)
    - PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Homo sapiens)
      - Me2aR12-histone H2A, MeR12-histone H2A [nucleoplasm] (Homo sapiens)
        
        MeR12-histone H2A [nucleoplasm] (Homo sapiens)
        
        MeR12-histone HIST H2A [nucleoplasm] (Homo sapiens)
        
        MeR12-HIST1H2AG [nucleoplasm] (Homo sapiens)
      - MeR12-histone H2A, Histone H2A [nucleoplasm] (Homo sapiens)
        
        MeR12-histone H2A [nucleoplasm] (Homo sapiens)
        
        MeR12-histone HIST H2A [nucleoplasm] (Homo sapiens)
        
        MeR12-HIST1H2AG [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P0C0S8 H2AC11

Gene Names

H2AC11, H2AFP, HIST1H2AG, H2AC13, H2AFC, HIST1H2AI, H2AC15, H2AFD, HIST1H2AK, H2AC16, H2AFI, HIST1H2AL, H2AC17, H2AFN, HIST1H2AM

Chain

initiator methionine:, chain:2-130

Reference Genes

BioGPS Gene:8329 H2AC11

BioGPS Gene:8330 H2AC11

BioGPS Gene:8332 H2AC11

BioGPS Gene:8336 H2AC11

BioGPS Gene:8969 H2AC11

CTD Gene:8329 H2AC11

CTD Gene:8330 H2AC11

CTD Gene:8332 H2AC11

CTD Gene:8336 H2AC11

CTD Gene:8969 H2AC11

dbSNP Gene:8329 H2AC11

dbSNP Gene:8330 H2AC11

dbSNP Gene:8332 H2AC11

dbSNP Gene:8336 H2AC11

dbSNP Gene:8969 H2AC11

ENSEMBL:ENSG00000196747 HIST1H2AI

ENSEMBL:ENSG00000196787 HIST1H2AG

ENSEMBL:ENSG00000275221 HIST1H2AK

ENSEMBL:ENSG00000276903 HIST1H2AL

ENSEMBL:ENSG00000278677 HIST1H2AM

ENSEMBL_homo_sapiens_GENE:ENSG00000196747.5 H2AC11

ENSEMBL_homo_sapiens_GENE:ENSG00000196787.4 H2AC11

ENSEMBL_homo_sapiens_GENE:ENSG00000275221.2 H2AC11

ENSEMBL_homo_sapiens_GENE:ENSG00000276903.2 H2AC11

ENSEMBL_homo_sapiens_GENE:ENSG00000278677.2 H2AC11

HGNC:4725 H2AC11

HGNC:4726 H2AC11

HGNC:4730 H2AC11

HGNC:4735 H2AC11

HGNC:4737 H2AC11

KEGG Gene (Homo sapiens):8329 H2AC11

KEGG Gene (Homo sapiens):8330 H2AC11

KEGG Gene (Homo sapiens):8332 H2AC11

KEGG Gene (Homo sapiens):8336 H2AC11

KEGG Gene (Homo sapiens):8969 H2AC11

Monarch:8329 H2AC11

Monarch:8330 H2AC11

Monarch:8332 H2AC11

Monarch:8336 H2AC11

Monarch:8969 H2AC11

NCBI Gene:8329 H2AC11

NCBI Gene:8330 H2AC11

NCBI Gene:8332 H2AC11

NCBI Gene:8336 H2AC11

NCBI Gene:8969 H2AC11

OMIM:602787 H2AC11

OMIM:602788 H2AC11

OMIM:602793 H2AC11

OMIM:602796 H2AC11

OMIM:615012 H2AC11

UCSC:P0C0S8 H2AC11

Reference Transcript

Other Identifiers

11715162_s_at

11715219_s_at

11734234_at

11737572_x_at

11740124_at

11740125_x_at

11759220_at

11759248_at

11759252_at

11759253_x_at

17005858

17005876

17016496

17016512

208583_PM_x_at

208583_x_at

214542_PM_x_at

214542_x_at

214554_PM_at

214554_at

2899757

2899758

2899759

2899760

2900048

2900094

2900095

2900096

2947042

2947043

2947044

2947045

2947065

2947066

2947103

2947104

2947105

31749_f_at

31768_at

33023_at

34156_i_at

34157_f_at

8117580

8117608

8124524

8124540

8329

8330

8332

8336

8969

ADDON002309.hg

ADDON002495.hg

ADDON002786.hg

ADDON002787.hg

ADDON002823.hg

A_14_P122573

A_14_P200168

A_14_P200169

A_21_P0000197

A_23_P168014

A_23_P363174

A_24_P217848

A_24_P303354

A_24_P394510

A_24_P86389

A_32_P221799

A_33_P3360216

GE535482

GE81292

GE81293

GE81294

GO:0000786

GO:0003677

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005694

GO:0008150

GO:0019899

GO:0030527

GO:0043226

GO:0043229

GO:0046982

GO:0070062

HMNXSV003003032

HMNXSV003020688

HMNXSV003021084

HMNXSV003039464

HMNXSV003050773

Hs.137592.0.S1_3p_at

Hs.137592.0.S1_3p_x_at

Hs.233568.0.S1_3p_at

ILMN_1663453

ILMN_1694699

ILMN_1756022

PH_hs_0007861

PH_hs_0028903

PH_hs_0031765

TC06000223.hg

TC06000269.hg

TC06001425.hg

TC06001430.hg

TC06004063.hg

Z83742_at

Participates

as a member of

MeR12-histone HIST H2A [nucleoplasm] (Homo sapiens)

Other forms of this molecule

K63polyUb-HIST1H2AG [nucleoplasm]

Ub-HIST1H2AG [nucleoplasm]

Ack6-HIST1H2AG [nucleoplasm]

Me2aR30-HIST1H2AG [nucleoplasm]

MeR30-HIST1H2AG [nucleoplasm]

Me2aR4-HIST1H2AG [nucleoplasm]

MeR4-HIST1H2AG [nucleoplasm]

Me2aR12-HIST1H2AG [nucleoplasm]

HIST1H2AG [nucleoplasm]

Ack-HIST1H2AG [nucleoplasm]

Inferred To

LOC100485548 [nucleoplasm] (Xenopus tropicalis)

H2AC13 [nucleoplasm] (Canis familiaris)

LOC100487632 [nucleoplasm] (Xenopus tropicalis)

LOC116411633 [nucleoplasm] (Xenopus tropicalis)

his-35 [nucleoplasm] (Caenorhabditis elegans)

HTA1 [nucleoplasm] (Saccharomyces cerevisiae)

H2AC10 [nucleoplasm] (Bos taurus)

HTA2 [nucleoplasm] (Saccharomyces cerevisiae)

H2Av2 [nucleoplasm] (Dictyostelium discoideum)

His2A:CG33862 [nucleoplasm] (Drosophila melanogaster)

MeR12-HIST1H2AB [nucleoplasm] (Gallus gallus)

MeR12-HIST1H2AB [nucleoplasm] (Plasmodium falciparum)

hta1 [nucleoplasm] (Schizosaccharomyces pombe)

H2AC14 [nucleoplasm] (Sus scrofa)

his-65 [nucleoplasm] (Caenorhabditis elegans)

Homologues of MeR12-HIST1H2AB [nucleoplasm] (Caenorhabditis elegans)

Homologues of MeR12-HIST1H2AB [nucleoplasm] (Danio rerio)

Homologues of MeR12-HIST1H2AB [nucleoplasm] (Dictyostelium discoideum)

Homologues of MeR12-HIST1H2AB [nucleoplasm] (Drosophila melanogaster)

Homologues of MeR12-HIST1H2AB [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of MeR12-HIST1H2AB [nucleoplasm] (Schizosaccharomyces pombe)

Homologues of MeR12-HIST1H2AB [nucleoplasm] (Xenopus tropicalis)

hta2 [nucleoplasm] (Schizosaccharomyces pombe)

h2ac16 [nucleoplasm] (Xenopus tropicalis)

LOC116407737 [nucleoplasm] (Xenopus tropicalis)

LOC100487067 [nucleoplasm] (Xenopus tropicalis)

h2ax1 [nucleoplasm] (Danio rerio)

zgc:56685 [nucleoplasm] (Danio rerio)

H2AX [nucleoplasm] (Dictyostelium discoideum)

H2Av3 [nucleoplasm] (Dictyostelium discoideum)

htas-1 [nucleoplasm] (Caenorhabditis elegans)

H2Av1 [nucleoplasm] (Dictyostelium discoideum)

LOC101732059 [nucleoplasm] (Xenopus tropicalis)

His2A:CG33859 [nucleoplasm] (Drosophila melanogaster)

Modified Residues

Name

omega-N-methyl-L-arginine at 12

Coordinate

PsiMod Name

omega-N-methyl-L-arginine

PsiMod Definition

A protein modification that effectively converts an L-arginine residue to N(omega)-methyl-L-arginine.

Cross References

RefSeq

NP_066408.1, NP_003505.1, NP_003501.1, NP_003502.1, NP_003500.1

OpenTargets

ENSG00000196787

GeneCards

P0C0S8

HPA

ENSG00000196787-H2AC11, ENSG00000196747-H2AC13, ENSG00000278677-H2AC17, ENSG00000275221-H2AC15, ENSG00000276903-H2AC16

Ensembl

ENSG00000196747, ENST00000618958, ENSG00000275221, ENST00000613174, ENSP00000352119, ENSP00000352627, ENSP00000482431, ENSP00000351589, ENSP00000482538, ENST00000358739, ENSG00000196787, ENST00000359611, ENSG00000276903, ENST00000359193, ENSG00000278677

PRO

P0C0S8

Pharos - Targets

P0C0S8

HMDB Protein

HMDBP07725

PDB

7U51, 7JOA, 7U50, 8GUK, 6X5A, 8OFF, 7UV9, 8ATF, 8GUJ, 7JO9, 7E8D, 7U53, 6XJD, 6R0C, 7BG9, 7TAN, 8GUI, 5KGF, 6X59, 6RNY, 4QYL, 7U52, 8AV6

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12888 TP53BP1	3	monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) TP53BP1 [nucleoplasm] (R-HSA-61175)	0.672	21
UniProt:P84233 Unknown	2	Ack15-histone H3.2 [nucleoplasm] (R-XLA-4549248) Histone H3.2 [nucleoplasm] (R-XLA-4549227)	0.65	14
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.65	14
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.643	3
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.564	2
UniProt:P06746 POLB	2	PolyUb-POLB [nucleoplasm] (R-HSA-6783152) POLB [nucleoplasm] (R-HSA-53845)	0.527	2
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.527	3
UniProt:Q9Y5B9 SUPT16H	1	SUPT16H [nucleoplasm] (R-HSA-112415)	0.527	3
UniProt:P09874 PARP1	4	polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) PARP1 [nucleoplasm] (R-HSA-201568)	0.527	2
UniProt:Q01831 XPC	5	XPC [nucleoplasm] (R-HSA-67441) Ub-XPC [nucleoplasm] (R-HSA-6782944) Ub,SUMO-XPC [nucleoplasm] (R-HSA-6790460) Ub,SUMO,K63polyUb-XPC [nucleoplasm] (R-HSA-6790522) monoSUMO1-K655-XPC [nucleoplasm] (R-HSA-4570458)	0.527	4
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) HIST1H4 [nucleoplasm] (R-HSA-181902)	0.527	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:P34741 SDC2	20	SDC2 [plasma membrane] (R-HSA-2090052) p-Y179,Y191-SDC2 [plasma membrane] (R-HSA-4093306) SDC2 [lysosomal lumen] (R-HSA-2090083) HS(6)-SDC2 [lysosomal lumen] (R-HSA-2090064) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(6)-SDC2 [Golgi lumen] (R-HSA-2076588) HS(5)-SDC2 [Golgi lumen] (R-HSA-2076320) Heparan-SDC2 [Golgi lumen] (R-HSA-2076608) Heparan(1)-SDC2 [Golgi lumen] (R-HSA-2076536) Heparan(2)-SDC2 [Golgi lumen] (R-HSA-2076397) Heparan(4)-SDC2 [Golgi lumen] (R-HSA-2076576) Heparan(3)-SDC2 [Golgi lumen] (R-HSA-2076361) SDC2 [Golgi lumen] (R-HSA-2054101) HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643)	0.527	2
UniProt:O95760 IL33	3	IL33 [nucleoplasm] (R-HSA-6783145) PolyUb-IL33 [nucleoplasm] (R-HSA-6783057) IL33 [extracellular region] (R-HSA-448567)	0.499	3

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