Reactome | MeR12-HIST1H2AG [nucleoplasm]

MeR12-HIST1H2AG [nucleoplasm]

Stable Identifier

R-HSA-5229206

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

HIST1H2AG, Histone H2A.1

Locations in the PathwayBrowser

Expand all

Chromatin organization (Homo sapiens)

- Chromatin modifying enzymes (Homo sapiens)
  - RMTs methylate histone arginines (Homo sapiens)
    - PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Homo sapiens)
      - Me2aR12-histone H2A, MeR12-histone H2A [nucleoplasm] (Homo sapiens)
        
        MeR12-histone H2A [nucleoplasm] (Homo sapiens)
        
        MeR12-histone HIST H2A [nucleoplasm] (Homo sapiens)
        
        MeR12-HIST1H2AG [nucleoplasm] (Homo sapiens)
      - MeR12-histone H2A, Histone H2A [nucleoplasm] (Homo sapiens)
        
        MeR12-histone H2A [nucleoplasm] (Homo sapiens)
        
        MeR12-histone HIST H2A [nucleoplasm] (Homo sapiens)
        
        MeR12-HIST1H2AG [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P0C0S8 H2AC11

Gene Names

H2AC11, H2AFP, HIST1H2AG, H2AC13, H2AFC, HIST1H2AI, H2AC15, H2AFD, HIST1H2AK, H2AC16, H2AFI, HIST1H2AL, H2AC17, H2AFN, HIST1H2AM

Chain

initiator methionine:1, chain:2-130

Reference Genes

BioGPS Gene:8329 H2AC11

BioGPS Gene:8330 H2AC11

BioGPS Gene:8332 H2AC11

BioGPS Gene:8336 H2AC11

BioGPS Gene:8969 H2AC11

CTD Gene:8329 H2AC11

CTD Gene:8330 H2AC11

CTD Gene:8332 H2AC11

CTD Gene:8336 H2AC11

CTD Gene:8969 H2AC11

dbSNP Gene:8329 H2AC11

dbSNP Gene:8330 H2AC11

dbSNP Gene:8332 H2AC11

dbSNP Gene:8336 H2AC11

dbSNP Gene:8969 H2AC11

ENSEMBL:ENSG00000196747 HIST1H2AI

ENSEMBL:ENSG00000196747.5 H2AC11

ENSEMBL:ENSG00000196787 HIST1H2AG

ENSEMBL:ENSG00000196787.4 H2AC11

ENSEMBL:ENSG00000275221 HIST1H2AK

ENSEMBL:ENSG00000275221.2 H2AC11

ENSEMBL:ENSG00000276903 HIST1H2AL

ENSEMBL:ENSG00000276903.2 H2AC11

ENSEMBL:ENSG00000278677 HIST1H2AM

ENSEMBL:ENSG00000278677.2 H2AC11

HGNC:4725 H2AC11

HGNC:4726 H2AC11

HGNC:4730 H2AC11

HGNC:4735 H2AC11

HGNC:4737 H2AC11

KEGG Gene (Homo sapiens):8329 H2AC11

KEGG Gene (Homo sapiens):8330 H2AC11

KEGG Gene (Homo sapiens):8332 H2AC11

KEGG Gene (Homo sapiens):8336 H2AC11

KEGG Gene (Homo sapiens):8969 H2AC11

Monarch:8329 H2AC11

Monarch:8330 H2AC11

Monarch:8332 H2AC11

Monarch:8336 H2AC11

Monarch:8969 H2AC11

NCBI Gene:8329 H2AC11

NCBI Gene:8330 H2AC11

NCBI Gene:8332 H2AC11

NCBI Gene:8336 H2AC11

NCBI Gene:8969 H2AC11

OMIM:602787 H2AC11

OMIM:602788 H2AC11

OMIM:602793 H2AC11

OMIM:602796 H2AC11

OMIM:615012 H2AC11

UCSC:P0C0S8 H2AC11

Reference Transcript

Other Identifiers

11715162_s_at

11715219_s_at

11734234_at

11737572_x_at

11740124_at

11740125_x_at

11759220_at

11759248_at

11759252_at

11759253_x_at

17005858

17005876

17016496

17016512

208583_PM_x_at

208583_x_at

214542_PM_x_at

214542_x_at

214554_PM_at

214554_at

2899757

2899758

2899759

2899760

2900048

2900094

2900095

2900096

2947042

2947043

2947044

2947045

2947065

2947066

2947103

2947104

2947105

31749_f_at

31768_at

33023_at

34156_i_at

34157_f_at

8117580

8117608

8124524

8124540

8329

8330

8332

8336

8969

ADDON002309.hg

ADDON002495.hg

ADDON002786.hg

ADDON002787.hg

ADDON002823.hg

A_14_P122573

A_14_P200168

A_14_P200169

A_21_P0000197

A_23_P168014

A_23_P363174

A_24_P217848

A_24_P303354

A_24_P394510

A_24_P86389

A_32_P221799

A_33_P3360216

GE535482

GE81292

GE81293

GE81294

GO:0000786

GO:0003677

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005694

GO:0008150

GO:0019899

GO:0030527

GO:0043226

GO:0043229

GO:0046982

GO:0070062

HMNXSV003003032

HMNXSV003020688

HMNXSV003021084

HMNXSV003039464

HMNXSV003050773

Hs.137592.0.S1_3p_at

Hs.137592.0.S1_3p_x_at

Hs.233568.0.S1_3p_at

ILMN_1663453

ILMN_1694699

ILMN_1756022

PH_hs_0007861

PH_hs_0028903

PH_hs_0031765

TC06000223.hg

TC06000269.hg

TC06001425.hg

TC06001430.hg

TC06004063.hg

Z83742_at

Participates

as a member of

MeR12-histone HIST H2A [nucleoplasm] (Homo sapiens)

Other forms of this molecule

K63polyUb-HIST1H2AG [nucleoplasm]

Ub-HIST1H2AG [nucleoplasm]

Ack6-HIST1H2AG [nucleoplasm]

Me2aR30-HIST1H2AG [nucleoplasm]

MeR30-HIST1H2AG [nucleoplasm]

Me2aR4-HIST1H2AG [nucleoplasm]

MeR4-HIST1H2AG [nucleoplasm]

Me2aR12-HIST1H2AG [nucleoplasm]

HIST1H2AG [nucleoplasm]

Ack-HIST1H2AG [nucleoplasm]

Inferred To

Homologues of MeR12-HIST1H2AB [nucleoplasm] (Dictyostelium discoideum)

Homologues of MeR12-HIST1H2AB [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of MeR12-HIST1H2AB [nucleoplasm] (Schizosaccharomyces pombe)

LOC100485548 [nucleoplasm] (Xenopus tropicalis)

hta2 [nucleoplasm] (Schizosaccharomyces pombe)

LOC100487632 [nucleoplasm] (Xenopus tropicalis)

LOC116407737 [nucleoplasm] (Xenopus tropicalis)

h2ax.2 [nucleoplasm] (Xenopus tropicalis)

HTA1 [nucleoplasm] (Saccharomyces cerevisiae)

LOC101734900 [nucleoplasm] (Xenopus tropicalis)

H2AC10 [nucleoplasm] (Bos taurus)

HTA2 [nucleoplasm] (Saccharomyces cerevisiae)

H2Av2 [nucleoplasm] (Dictyostelium discoideum)

h2ax [nucleoplasm] (Danio rerio)

h2ax [nucleoplasm] (Xenopus tropicalis)

LOC100148591 [nucleoplasm] (Danio rerio)

h2ac14 [nucleoplasm] (Xenopus tropicalis)

H2AX [nucleoplasm] (Dictyostelium discoideum)

H2Av3 [nucleoplasm] (Dictyostelium discoideum)

MeR12-HIST1H2AB [nucleoplasm] (Plasmodium falciparum)

MeR12-HIST1H2AB [nucleoplasm] (Xenopus tropicalis)

MeR12-HIST1H2AG [nucleoplasm] (Canis familiaris)

MeR12-HIST1H2AG [nucleoplasm] (Sus scrofa)

H2Av1 [nucleoplasm] (Dictyostelium discoideum)

h2ac12 [nucleoplasm] (Xenopus tropicalis)

hta1 [nucleoplasm] (Schizosaccharomyces pombe)

H2AC15 [nucleoplasm] (Canis familiaris)

Homologues of MeR12-HIST1H2AG [nucleoplasm] (Canis familiaris)

Homologues of MeR12-HIST1H2AG [nucleoplasm] (Danio rerio)

Homologues of MeR12-HIST1H2AG [nucleoplasm] (Xenopus tropicalis)

LOC100491383 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

omega-N-methyl-L-arginine at 12

Coordinate

PsiMod Name

omega-N-methyl-L-arginine

PsiMod Definition

A protein modification that effectively converts an L-arginine residue to N(omega)-methyl-L-arginine.

Cross References

RefSeq

NP_003505.1, NP_003501.1, NP_003502.1, NP_066408.1, NP_003500.1

OpenTargets

ENSG00000196787

GeneCards

P0C0S8

HPA

ENSG00000196747-H2AC13, ENSG00000278677-H2AC17, ENSG00000196787-H2AC11, ENSG00000275221-H2AC15, ENSG00000276903-H2AC16

Ensembl

ENSG00000196787, ENSG00000275221, ENSG00000276903, ENSG00000278677, ENST00000359193, ENSG00000196747, ENSP00000482538, ENSP00000482431, ENSP00000352119, ENSP00000351589, ENST00000359611, ENSP00000352627, ENST00000618958, ENST00000613174, ENST00000358739

PRO

P0C0S8

Pharos - Targets

P0C0S8

HMDB Protein

HMDBP07725

PDB

6X5A, 7E8D, 7U51, 7TAN, 4QYL, 6RNY, 7U53, 7JO9, 5KGF, 7U52, 6X59, 6XJD, 6R0C, 7JOA, 7UV9, 7U50, 7BG9

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12888 TP53BP1	3	monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) TP53BP1 [nucleoplasm] (R-HSA-61175) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418)	0.672	21
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.65	14
UniProt:P84233 Histone H3.2	2	Ack15-histone H3.2 [nucleoplasm] (R-XLA-4549248) Histone H3.2 [nucleoplasm] (R-XLA-4549227)	0.65	14
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.564	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.527	2
UniProt:O95760 IL33	3	IL33 [nucleoplasm] (R-HSA-6783145) PolyUb-IL33 [nucleoplasm] (R-HSA-6783057) IL33 [extracellular region] (R-HSA-448567)	0.499	3

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