Reactome | Ub-C145-UBE2E3 [nucleoplasm]

Ub-C145-UBE2E3 [nucleoplasm]

Stable Identifier

R-HSA-8864208

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Ubiquitin-conjugating enzyme E2 E3 ecNumber evidence="8"2.3.2.23/ecNumber, UB2E3_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Protein ubiquitination (Homo sapiens)
    - Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
      - UBA1 conjugates ubiquitin to nuclear E2 enzymes (Homo sapiens)
        
        Ub:E2 (UBA1 substrate) [nucleoplasm] (Homo sapiens)
        
        Ub-conjugated E2 enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)
        
        Ub-C145-UBE2E3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q969T4 UBE2E3

Gene Names

UBE2E3, UBCE4, UBCH9

Chain

initiator methionine:, chain:2-207

Reference Genes

BioGPS Gene:10477 UBE2E3

COSMIC (genes):UBE2E3 UBE2E3

CTD Gene:10477 UBE2E3

dbSNP Gene:10477 UBE2E3

ENSEMBL:ENSG00000170035 UBE2E3

HGNC:12479 UBE2E3

KEGG:hsa:10477 UBE2E3

Monarch:10477 UBE2E3

NCBI Gene:10477 UBE2E3

OMIM:604151 UBE2E3

UCSC:Q969T4 UBE2E3

Reference Transcript

Other Identifiers

10477

11742138_a_at

11742946_s_at

16888232

210024_PM_s_at

210024_s_at

2518164

2518165

2518166

2518167

2518168

2518169

2518170

2518171

2518172

2518175

2518177

2518195

2518196

2518198

2518199

2518200

2518201

2518202

2518209

2518211

34850_at

3969607

3969608

63933_s_at

8046685

A_19_P00323103

A_19_P00326822

A_23_P11192

A_24_P148450

A_33_P3223712

A_33_P3223713

GE61012

GO:0000209

GO:0003824

GO:0004842

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0016567

GO:0016740

GO:0019787

GO:0043226

GO:0061631

GO:0070534

GO:0070936

GO:0070979

GO:0140096

HMNXSV003005459

HMNXSV003036375

ILMN_1669553

ILMN_1708463

ILMN_1733142

ILMN_1765714

ILMN_1809652

ILMN_2390338

TC02003727.hg

g4586929_3p_a_at

p21277

Participates

as a member of

Ub-conjugated E2 enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)

Other forms of this molecule

UBE2E3 [cytosol]

UBE2E3 [nucleoplasm]

Ub-C145-UBE2E3 [cytosol]

Inferred To

Ube2e3 [nucleoplasm] (Mus musculus)

Ube2e3 [nucleoplasm] (Rattus norvegicus)

Dmel\CG2574 [nucleoplasm] (Drosophila melanogaster)

Ub-C145-UBE2E3 [nucleoplasm] (Dictyostelium discoideum)

Ub-C145-UBE2E3 [nucleoplasm] (Gallus gallus)

Ub-C145-UBE2E3 [nucleoplasm] (Sus scrofa)

UBE2E3 [nucleoplasm] (Bos taurus)

UBE2E3 [nucleoplasm] (Canis familiaris)

ube2e3 [nucleoplasm] (Danio rerio)

ube2e3 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

S-(glycyl)-L-cysteine (Cys-Gly) at 145

Coordinate

145

PsiMod Name

S-(glycyl)-L-cysteine (Cys-Gly)

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Cross References

RefSeq

NP_001265483.1, NP_001265484.1, XP_005246301.1, NP_006348.1, NP_872619.1

OpenTargets

ENSG00000170035

ENSEMBL

ENSP00000376215, ENST00000602710, ENST00000392415, ENSP00000473623, ENSP00000473639, ENST00000410062, ENST00000602959, ENSP00000386788

IntEnz

2.3.2.23

HPA

ENSG00000170035-UBE2E3

PRO

Q969T4

Pharos - Targets

Q969T4

HMDB Protein

HMDBP00593

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q6ZNA4 RNF111	2	RNF111 [cytosol] (R-HSA-975981) RNF111 [nucleoplasm] (R-HSA-2186765)	0.553	2
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.527	2
UniProt:Q9NS56 TOPORS	2	monoSUMO1-K560-TOPORS [nucleoplasm] (R-HSA-4551754) TOPORS [nucleoplasm] (R-HSA-2993791)	0.527	2
UniProt:Q96NR8 RDH12	6	RDH12 A126V [photoreceptor inner segment membrane] (R-HSA-2471753) RDH12 Q189* [photoreceptor inner segment membrane] (R-HSA-2471667) RDH12 Y226C [photoreceptor inner segment membrane] (R-HSA-2471697) RDH12 H151N [photoreceptor inner segment membrane] (R-HSA-2471751) RDH12 Ala269Glyfs*2 [photoreceptor inner segment membrane] (R-HSA-2471748) RDH12 [photoreceptor inner segment membrane] (R-HSA-2464787)	0.527	2

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