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ATF7IP [nucleoplasm]
Stable Identifier
R-HSA-3301918
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Activating transcription factor 7-interacting protein 1, MCAF1_HUMAN
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
PKMTs methylate histone lysines (Homo sapiens)
ATF7IP binds SETDB1 (Homo sapiens)
ATF7IP [nucleoplasm] (Homo sapiens)
ATF7IP:SETDB1 [nucleoplasm] (Homo sapiens)
ATF7IP [nucleoplasm] (Homo sapiens)
SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Homo sapiens)
ATF7IP:SETDB1 [nucleoplasm] (Homo sapiens)
ATF7IP [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Regulation of endogenous retroelements (Homo sapiens)
Regulation of endogenous retroelements by KRAB-ZFP proteins (Homo sapiens)
ATF7IP:SETDB1 binds SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin (Homo sapiens)
ATF7IP:SETDB1 [nucleoplasm] (Homo sapiens)
ATF7IP [nucleoplasm] (Homo sapiens)
ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
ATF7IP:SETDB1 [nucleoplasm] (Homo sapiens)
ATF7IP [nucleoplasm] (Homo sapiens)
SETDB1 in ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement trimethylates lysine-9 of histone H3 in nucleosomes (Homo sapiens)
ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
ATF7IP:SETDB1 [nucleoplasm] (Homo sapiens)
ATF7IP [nucleoplasm] (Homo sapiens)
ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin with H3K9me3 [nucleoplasm] (Homo sapiens)
ATF7IP:SETDB1 [nucleoplasm] (Homo sapiens)
ATF7IP [nucleoplasm] (Homo sapiens)
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex (Homo sapiens)
EHMT1,EHMT2 trimethylates lysine-16 of ATF7IP (Homo sapiens)
ATF7IP [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6VMQ6 ATF7IP
Gene Names
ATF7IP, MCAF, MCAF1
Chain
chain:1-1270
Reference Genes
BioGPS Gene:55729 ATF7IP
COSMIC (genes):ATF7IP ATF7IP
CTD Gene:55729 ATF7IP
dbSNP Gene:55729 ATF7IP
ENSEMBL:ENSG00000171681 ATF7IP
HGNC:20092 ATF7IP
KEGG:hsa:55729 ATF7IP
Monarch:55729 ATF7IP
NCBI Gene:55729 ATF7IP
OMIM:613644 ATF7IP
UCSC:Q6VMQ6 ATF7IP
Reference Transcript
RefSeq:XM_011520755.2 ATF7IP
RefSeq:XM_011520754.2 ATF7IP
RefSeq:XM_006719109.3 ATF7IP
RefSeq:XM_017019638.1 ATF7IP
RefSeq:XM_017019639.1 ATF7IP
RefSeq:NM_001286515.1 ATF7IP
RefSeq:XM_006719108.3 ATF7IP
RefSeq:NM_181352.1 ATF7IP
RefSeq:NM_001286514.1 ATF7IP
RefSeq:NM_018179.4 ATF7IP
Participates
as an input of
EHMT1,EHMT2 trimethylates lysine-16 of ATF7IP (Homo sapiens)
ATF7IP binds SETDB1 (Homo sapiens)
as a component of
ATF7IP:SETDB1 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
me3-K16-ATF7IP [nucleoplasm]
Inferred To
atf7ip [nucleoplasm]
(Danio rerio)
atf7ip [nucleoplasm]
(Xenopus tropicalis)
Atf7ip [nucleoplasm]
(Mus musculus)
Atf7ip [nucleoplasm]
(Rattus norvegicus)
wde [nucleoplasm]
(Drosophila melanogaster)
ATF7IP [nucleoplasm]
(Bos taurus)
ATF7IP [nucleoplasm]
(Canis familiaris)
ATF7IP [nucleoplasm]
(Gallus gallus)
ATF7IP [nucleoplasm]
(Sus scrofa)
Cross References
ENSEMBL
ENST00000540793
,
ENSP00000444589
,
ENSP00000445955
,
ENSP00000443179
,
ENST00000536444
,
ENST00000261168
,
ENSP00000261168
,
ENST00000543189
,
ENSG00000171681
,
ENSP00000440440
,
ENST00000544627
OpenTargets
ENSG00000171681
GeneCards
ATF7IP
HPA
ENSG00000171681-ATF7IP
PRO
Q6VMQ6
Pharos - Targets
Q6VMQ6
GlyGen
Q6VMQ6
PDB
2RPQ
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8N8R7 AL14E
0.564
2
UniProt:Q13485 SMAD4
20
SMAD4 P356R [cytosol]
(R-HSA-3310988)
SMAD4 K428T [cytosol]
(R-HSA-3311004)
SMAD4 D351del [cytosol]
(R-HSA-3310974)
SMAD4 R361H [cytosol]
(R-HSA-3310984)
SMAD4 P356L [cytosol]
(R-HSA-3310987)
SMAD4 A406T [cytosol]
(R-HSA-3311003)
SMAD4 D351Y [cytosol]
(R-HSA-3310970)
SMAD4 D351H [cytosol]
(R-HSA-3310965)
SMAD4 R361C [cytosol]
(R-HSA-3310983)
SMAD4 D351G [cytosol]
(R-HSA-3310967)
SMAD4 R515T [cytosol]
(R-HSA-3311008)
SMAD4 G352* [cytosol]
(R-HSA-9678445)
SMAD4 S178* [cytosol]
(R-HSA-9675630)
SMAD4 G477* [cytosol]
(R-HSA-9678447)
SMAD4 G473* [cytosol]
(R-HSA-9678440)
SMAD4 S144* [cytosol]
(R-HSA-9675625)
SMAD4 E538* [cytosol]
(R-HSA-9675626)
SMAD4 E390* [cytosol]
(R-HSA-9675620)
SMAD4 S154* [cytosol]
(R-HSA-9675621)
SMAD4 E330* [cytosol]
(R-HSA-9675622)
0.553
2
UniProt:Q96PV0 SYNGAP1
1
SYNGAP1 [cytosol]
(R-HSA-5658217)
0.527
5
UniProt:Q9UHL9 GT2D1
0.508
3
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