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me3-K16-ATF7IP [nucleoplasm]
Stable Identifier
R-HSA-9844104
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
fullName evidence="19"Activating transcription factor 7-interacting protein 1, MCAF1_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Regulation of endogenous retroelements (Homo sapiens)
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex (Homo sapiens)
EHMT1,EHMT2 trimethylates lysine-16 of ATF7IP (Homo sapiens)
me3-K16-ATF7IP [nucleoplasm] (Homo sapiens)
SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3) (Homo sapiens)
me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP:SETDB1 [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP [nucleoplasm] (Homo sapiens)
SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome (Homo sapiens)
me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP:SETDB1 [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP:SETDB1 and MORC2 bind MPHOSPH8 (MPP8) in HUSH complex:L1 RNA (Homo sapiens)
me3-K16-ATF7IP:SETDB1 [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP:SETDB1 [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP:SETDB1 and MORC2 bind MPHOSPH8 (MPP8) in HUSH complex:L1HS,L1PA2,3 heterochromatin (Homo sapiens)
me3-K16-ATF7IP:SETDB1 [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP:SETDB1 [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6VMQ6 ATF7IP
Gene Names
ATF7IP, MCAF, MCAF1
Chain
chain:1-1270
Reference Genes
COSMIC (genes):ATF7IP ATF7IP
dbSNP Gene:55729 ATF7IP
ENSEMBL:ENSG00000171681 ATF7IP
Participates
as an output of
EHMT1,EHMT2 trimethylates lysine-16 of ATF7IP (Homo sapiens)
as a component of
me3-K16-ATF7IP:SETDB1 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
ATF7IP [nucleoplasm]
Inferred To
atf7ip [nucleoplasm]
(Danio rerio)
Atf7ip [nucleoplasm]
(Rattus norvegicus)
me3-K16-ATF7IP [nucleoplasm]
(Gallus gallus)
ATF7IP [nucleoplasm]
(Bos taurus)
ATF7IP [nucleoplasm]
(Canis familiaris)
ATF7IP [nucleoplasm]
(Sus scrofa)
Modified Residues
Name
N6,N6,N6-trimethyl-L-lysine at 16
Coordinate
16
PsiMod Name
N6,N6,N6-trimethyl-L-lysine [MOD:00083]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine.
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8N8R7 AL14E
0.564
2
UniProt:Q13485 SMAD4
20
SMAD4 P356R [cytosol]
(R-HSA-3310988)
SMAD4 K428T [cytosol]
(R-HSA-3311004)
SMAD4 D351del [cytosol]
(R-HSA-3310974)
SMAD4 R361H [cytosol]
(R-HSA-3310984)
SMAD4 P356L [cytosol]
(R-HSA-3310987)
SMAD4 A406T [cytosol]
(R-HSA-3311003)
SMAD4 D351Y [cytosol]
(R-HSA-3310970)
SMAD4 D351H [cytosol]
(R-HSA-3310965)
SMAD4 R361C [cytosol]
(R-HSA-3310983)
SMAD4 D351G [cytosol]
(R-HSA-3310967)
SMAD4 R515T [cytosol]
(R-HSA-3311008)
SMAD4 G352* [cytosol]
(R-HSA-9678445)
SMAD4 S178* [cytosol]
(R-HSA-9675630)
SMAD4 G477* [cytosol]
(R-HSA-9678447)
SMAD4 G473* [cytosol]
(R-HSA-9678440)
SMAD4 S144* [cytosol]
(R-HSA-9675625)
SMAD4 E538* [cytosol]
(R-HSA-9675626)
SMAD4 E390* [cytosol]
(R-HSA-9675620)
SMAD4 S154* [cytosol]
(R-HSA-9675621)
SMAD4 E330* [cytosol]
(R-HSA-9675622)
0.553
2
UniProt:Q96PV0 SYNGAP1
1
SYNGAP1 [cytosol]
(R-HSA-5658217)
0.527
5
UniProt:Q9UHL9 GT2D1
0.508
3
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