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FAAP100 [nucleoplasm]
Stable Identifier
R-HSA-419545
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Fanconi anemia-associated protein of 100 kDa, FP100_HUMAN
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Fanconi Anemia Pathway (Homo sapiens)
ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FAAP100 [nucleoplasm] (Homo sapiens)
p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FAAP100 [nucleoplasm] (Homo sapiens)
DNA nucleases bind monoubiquitinated ID2 complex (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FAAP100 [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FAAP100 [nucleoplasm] (Homo sapiens)
DNA nucleases unhook the interstrand crosslink (ICL) (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FAAP100 [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
FA core complex [nucleoplasm] (Homo sapiens)
FAAP100 [nucleoplasm] (Homo sapiens)
FA core complex assembles at DNA interstrand crosslinks (ICLs) (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FAAP100 [nucleoplasm] (Homo sapiens)
FAAP100 [nucleoplasm] (Homo sapiens)
FANCD2 deubiquitination by USP1:WDR48 (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FAAP100 [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FAAP100 [nucleoplasm] (Homo sapiens)
FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FAAP100 [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FAAP100 [nucleoplasm] (Homo sapiens)
Monoubiquitination of FANCD2:FANCI (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FAAP100 [nucleoplasm] (Homo sapiens)
p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FAAP100 [nucleoplasm] (Homo sapiens)
POLN binds ICL-DNA (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
FA core complex [nucleoplasm] (Homo sapiens)
FAAP100 [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
FA core complex [nucleoplasm] (Homo sapiens)
FAAP100 [nucleoplasm] (Homo sapiens)
The complex of ATR and ATRIP is recruited to ICL-DNA (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FAAP100 [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FAAP100 [nucleoplasm] (Homo sapiens)
Translesion synthesis across unhooked ICL by POLN (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
FA core complex [nucleoplasm] (Homo sapiens)
FAAP100 [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FAAP100 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q0VG06 FAAP100
Gene Names
FAAP100, C17orf70
Chain
chain:1-881
Reference Genes
BioGPS Gene:80233 FAAP100
COSMIC (genes):FAAP100 FAAP100
CTD Gene:80233 FAAP100
dbSNP Gene:80233 FAAP100
ENSEMBL:ENSG00000185504 FAAP100
HGNC:26171 FAAP100
KEGG:hsa:80233 FAAP100
Monarch:80233 FAAP100
NCBI Gene:80233 FAAP100
OMIM:611301 FAAP100
UCSC:Q0VG06 FAAP100
Reference Transcript
RefSeq:NM_025161.5 FAAP100
RefSeq:XM_017025163.1 FAAP100
RefSeq:XM_006722112.3 FAAP100
RefSeq:XM_017025162.1 FAAP100
Participates
as a component of
FA core complex [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
as an input of
FA core complex assembles at DNA interstrand crosslinks (ICLs) (Homo sapiens)
Other forms of this molecule
FAAP100 [cytosol]
Inferred To
FAAP100 [nucleoplasm]
(Bos taurus)
FAAP100 [nucleoplasm]
(Canis familiaris)
FAAP100 [nucleoplasm]
(Gallus gallus)
FAAP100 [nucleoplasm]
(Sus scrofa)
Faap100 [nucleoplasm]
(Mus musculus)
Faap100 [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of FAAP100 [nucleoplasm]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENSG00000185504
,
ENST00000327787
,
ENSP00000333283
OpenTargets
ENSG00000185504
GeneCards
FAAP100
HPA
ENSG00000185504-FAAP100
PRO
Q0VG06
Pharos - Targets
Q0VG06
GlyGen
Q0VG06
PDB
7KZP
,
7KZQ
,
7KZR
,
7KZS
,
7KZT
,
7KZV
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15360 FANCA
2
FANCA [cytosol]
(R-HSA-420796)
FANCA [nucleoplasm]
(R-HSA-419541)
0.662
4
UniProt:Q8NB91 FANCB
2
FANCB [cytosol]
(R-HSA-420791)
FANCB [nucleoplasm]
(R-HSA-419528)
0.556
4
UniProt:Q969T3 SNX21
0.527
3
UniProt:Q96PV0 SYNGAP1
1
SYNGAP1 [cytosol]
(R-HSA-5658217)
0.527
3
UniProt:Q9UJT2 TSKS
0.527
2
UniProt:Q96KS9 F167A
0.527
2
UniProt:Q96T91 GPHA2
1
GPHA2 [extracellular region]
(R-HSA-8942422)
0.527
2
UniProt:O95721 SNAP29
3
SNAP29 [azurophil granule membrane]
(R-HSA-6799359)
SNAP29 [plasma membrane]
(R-HSA-2029020)
SNAP29 [Golgi membrane]
(R-HSA-6810997)
0.527
2
UniProt:Q96ES7 SGF29
1
SGF29 [nucleoplasm]
(R-HSA-3662279)
0.527
4
UniProt:Q8WTQ7 GRK7
1
GRK7 [photoreceptor disc membrane]
(R-HSA-6787797)
0.499
2
UniProt:Q53S33 BOLA3
0.499
2
UniProt:Q9NW38 FANCL
2
FANCL [cytosol]
(R-HSA-420789)
FANCL [nucleoplasm]
(R-HSA-419520)
0.482
2
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