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LEMD2 [nuclear envelope]
Stable Identifier
R-HSA-3067329
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nuclear envelope
Synonyms
LEM2, LEM domain-containing protein 2
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Nuclear Envelope (NE) Reassembly (Homo sapiens)
Initiation of Nuclear Envelope (NE) Reformation (Homo sapiens)
BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Homo sapiens)
EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
LEMD2 [nuclear envelope] (Homo sapiens)
EMD/TMPO/LEMD3/LEMD2:Lamin filaments:BANF1:Chromatin [nuclear envelope] (Homo sapiens)
EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
LEMD2 [nuclear envelope] (Homo sapiens)
Sealing of the nuclear envelope (NE) by ESCRT-III (Homo sapiens)
CHMP7 binds CC2D1B (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
LEMD2 [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
LEMD2 [nuclear envelope] (Homo sapiens)
CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Homo sapiens)
LEMD2:CHMP7 [nuclear envelope] (Homo sapiens)
LEMD2 [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
LEMD2 [nuclear envelope] (Homo sapiens)
CHMP7 binds LEMD2 (Homo sapiens)
LEMD2 [nuclear envelope] (Homo sapiens)
LEMD2:CHMP7 [nuclear envelope] (Homo sapiens)
LEMD2 [nuclear envelope] (Homo sapiens)
SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
LEMD2 [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
LEMD2 [nuclear envelope] (Homo sapiens)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
LEMD2 [nuclear envelope] (Homo sapiens)
VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
LEMD2 [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST:VPS4A [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
LEMD2 [nuclear envelope] (Homo sapiens)
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST:VPS4A [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
LEMD2 [nuclear envelope] (Homo sapiens)
LEMD2 [nuclear envelope] (Homo sapiens)
Mitotic Prophase (Homo sapiens)
Nuclear Envelope Breakdown (Homo sapiens)
Depolymerization of the Nuclear Lamina (Homo sapiens)
Depolymerization of lamin filaments after PKC-mediated phosphorylation (Homo sapiens)
EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
LEMD2 [nuclear envelope] (Homo sapiens)
EMD/TMPO/LEMD3/LEMD2:Lamin filaments [nuclear envelope] (Homo sapiens)
EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
LEMD2 [nuclear envelope] (Homo sapiens)
VRK1/VRK2 phosphorylate BANF1 (Homo sapiens)
EMD/TMPO/LEMD3/LEMD2:Lamin filaments [nuclear envelope] (Homo sapiens)
EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
LEMD2 [nuclear envelope] (Homo sapiens)
EMD/TMPO/LEMD3/LEMD2:Lamin filaments:BANF1:Chromatin [nuclear envelope] (Homo sapiens)
EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
LEMD2 [nuclear envelope] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NC56 LEMD2
Gene Names
LEMD2
Chain
initiator methionine:, chain:2-503
Reference Genes
BioGPS Gene:221496 LEMD2
COSMIC (genes):LEMD2 LEMD2
CTD Gene:221496 LEMD2
dbSNP Gene:221496 LEMD2
ENSEMBL:ENSG00000161904 LEMD2
ENSEMBL_homo_sapiens_GENE:ENSG00000161904.13 LEMD2
HGNC:21244 LEMD2
Monarch:221496 LEMD2
NCBI Gene:221496 LEMD2
OMIM:616312 LEMD2
UCSC:Q8NC56 LEMD2
Reference Transcript
RefSeq:NM_001143944.1 LEMD2
RefSeq:NM_001348709.1 LEMD2
RefSeq:NM_181336.3 LEMD2
Other Identifiers
11741576_a_at
11741577_a_at
11743335_s_at
17018309
221496
224980_PM_at
224980_at
2950848
2950849
2950850
2950851
2950852
2950853
2950854
2950855
2950856
2950860
2950861
2950865
2950867
2950868
2950870
2950872
2950873
2950874
2950875
2950876
2950877
2950878
2950879
2950880
60869_at
65458_at
8125788
A_24_P305960
GE87062
GO:0000785
GO:0005515
GO:0005634
GO:0005635
GO:0005637
GO:0005694
GO:0005737
GO:0005783
GO:0005819
GO:0005856
GO:0006998
GO:0012505
GO:0016020
GO:0022008
GO:0023052
GO:0030154
GO:0031965
GO:0031967
GO:0035914
GO:0043226
GO:0043409
GO:0048856
GO:0051898
GO:0060914
GO:0061024
GO:0071168
HMNXSV003021739
Hs.164919.0.S1_3p_at
Hs.164919.0.S1_3p_x_at
ILMN_1680860
PH_hs_0033512
TC06001593.hg
Participates
as an input of
CHMP7 binds LEMD2 (Homo sapiens)
as a component of
LEMD2:CHMP7 [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
as an output of
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)
as a candidate of
EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
Inferred To
SRC1 [nuclear envelope]
(Saccharomyces cerevisiae)
Ghost homologue of LEMD2 [nuclear envelope]
(Bos taurus)
Ghost homologue of LEMD2 [nuclear envelope]
(Caenorhabditis elegans)
Ghost homologue of LEMD2 [nuclear envelope]
(Canis familiaris)
Ghost homologue of LEMD2 [nuclear envelope]
(Danio rerio)
Ghost homologue of LEMD2 [nuclear envelope]
(Drosophila melanogaster)
Ghost homologue of LEMD2 [nuclear envelope]
(Gallus gallus)
Ghost homologue of LEMD2 [nuclear envelope]
(Mus musculus)
Ghost homologue of LEMD2 [nuclear envelope]
(Rattus norvegicus)
Ghost homologue of LEMD2 [nuclear envelope]
(Sus scrofa)
Ghost homologue of LEMD2 [nuclear envelope]
(Xenopus tropicalis)
lem2 [nuclear envelope]
(Schizosaccharomyces pombe)
LEMD2 [nuclear envelope]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_001137416.1
,
NP_001335638.1
,
NP_851853.1
OpenTargets
ENSG00000161904
GeneCards
Q8NC56
HPA
ENSG00000161904-LEMD2
Ensembl
ENSP00000293760
,
ENST00000293760
,
ENST00000508327
,
ENSP00000421704
,
ENSG00000161904
PRO
Q8NC56
Pharos - Targets
Q8NC56
Orphanet
24014
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96PV0 SYNGAP1
1
SYNGAP1 [cytosol]
(R-HSA-5658217)
0.527
2
UniProt:P02545 LMNA
3
LMNA(1-646) [nuclear envelope]
(R-HSA-535479)
LMNA(1-567)-RAF1(279-648) fusion [cytosol]
(R-HSA-6802399)
LMNA(1-567)-p-RAF1(279-648) fusion [cytosol]
(R-HSA-6802537)
0.491
2
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