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ISL1 [nucleoplasm]
Stable Identifier
R-HSA-400478
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Insulin gene enhancer protein ISL-1, ISL1_HUMAN, Islet-1, ISL LIM homeobox 1
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Cardiogenesis (Homo sapiens)
Expression of HAND2 in cardiogenesis (Homo sapiens)
GATA4:GATA6:ISL1:LDB1:HAND2 gene [nucleoplasm] (Homo sapiens)
ISL1:LDB1 [nucleoplasm] (Homo sapiens)
ISL1 [nucleoplasm] (Homo sapiens)
Expression of ISL1 in cardiogenesis (Homo sapiens)
ISL1 [nucleoplasm] (Homo sapiens)
Expression of MEF2C in cardiogenesis (Homo sapiens)
GATA4:ISL1:LDB1:NKX2-5:TBX20:MEF2C gene [nucleoplasm] (Homo sapiens)
ISL1 [nucleoplasm] (Homo sapiens)
GATA4, GATA6, and ISL1:LDB1 bind the HAND2 gene (Homo sapiens)
GATA4:GATA6:ISL1:LDB1:HAND2 gene [nucleoplasm] (Homo sapiens)
ISL1:LDB1 [nucleoplasm] (Homo sapiens)
ISL1 [nucleoplasm] (Homo sapiens)
ISL1:LDB1 [nucleoplasm] (Homo sapiens)
ISL1 [nucleoplasm] (Homo sapiens)
GATA4, ISL1:LDB1, TBX20, and NKX2-5 bind the MEF2C gene (Homo sapiens)
GATA4:ISL1:LDB1:NKX2-5:TBX20:MEF2C gene [nucleoplasm] (Homo sapiens)
ISL1 [nucleoplasm] (Homo sapiens)
ISL1:LDB1 [nucleoplasm] (Homo sapiens)
ISL1 [nucleoplasm] (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Regulation of expression of SLITs and ROBOs (Homo sapiens)
ISL1 binds the SLIT2 gene enhancer (Homo sapiens)
ISL1:LHX3/4:LDB1 [nucleoplasm] (Homo sapiens)
ISL1:LHX3:LDB1 [nucleoplasm] (Homo sapiens)
ISL1 [nucleoplasm] (Homo sapiens)
ISL1:LHX4:LDB1 [nucleoplasm] (Homo sapiens)
ISL1 [nucleoplasm] (Homo sapiens)
ISL1:LHX3/4:LDB1:SLIT2 gene [nucleoplasm] (Homo sapiens)
ISL1:LHX3/4:LDB1 [nucleoplasm] (Homo sapiens)
ISL1:LHX3:LDB1 [nucleoplasm] (Homo sapiens)
ISL1 [nucleoplasm] (Homo sapiens)
ISL1:LHX4:LDB1 [nucleoplasm] (Homo sapiens)
ISL1 [nucleoplasm] (Homo sapiens)
SLIT2 gene expression is stimulated by ISL1 (Homo sapiens)
ISL1:LHX3/4:LDB1 [nucleoplasm] (Homo sapiens)
ISL1:LHX3:LDB1 [nucleoplasm] (Homo sapiens)
ISL1 [nucleoplasm] (Homo sapiens)
ISL1:LHX4:LDB1 [nucleoplasm] (Homo sapiens)
ISL1 [nucleoplasm] (Homo sapiens)
ISL1:LHX3/4:LDB1:SLIT2 gene [nucleoplasm] (Homo sapiens)
ISL1:LHX3/4:LDB1 [nucleoplasm] (Homo sapiens)
ISL1:LHX3:LDB1 [nucleoplasm] (Homo sapiens)
ISL1 [nucleoplasm] (Homo sapiens)
ISL1:LHX4:LDB1 [nucleoplasm] (Homo sapiens)
ISL1 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Incretin synthesis, secretion, and inactivation (Homo sapiens)
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (Homo sapiens)
Synthesis of prepro-Glucose-dependent Insulinotropic Polypeptide (preproGIP) in intestinal K cells (Homo sapiens)
ISL1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P61371 ISL1
Gene Names
ISL1
Chain
chain:1-349
Reference Genes
BioGPS Gene:3670 ISL1
COSMIC (genes):ISL1 ISL1
CTD Gene:3670 ISL1
dbSNP Gene:3670 ISL1
ENSEMBL:ENSG00000016082 ISL1
ENSEMBL_homo_sapiens_GENE:ENSG00000016082.15 ISL1
HGNC:6132 ISL1
KEGG Gene (Homo sapiens):3670 ISL1
Monarch:3670 ISL1
NCBI Gene:3670 ISL1
OMIM:600366 ISL1
UCSC:P61371 ISL1
Reference Transcript
RefSeq:NM_002202.2 ISL1
Other Identifiers
11725757_at
11725758_at
16984612
206104_PM_at
206104_at
2808943
2808944
2808945
2808947
2808950
2808954
2808957
2808960
2808961
2808962
2808963
3670
39990_at
8105220
A_14_P112433
A_14_P201897
A_23_P81529
GE58893
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0000987
GO:0001228
GO:0001755
GO:0003007
GO:0003013
GO:0003139
GO:0003148
GO:0003151
GO:0003203
GO:0003215
GO:0003266
GO:0003677
GO:0003682
GO:0005515
GO:0005634
GO:0005694
GO:0005737
GO:0006351
GO:0006355
GO:0006366
GO:0006954
GO:0007409
GO:0007507
GO:0008283
GO:0008284
GO:0010468
GO:0010575
GO:0012501
GO:0016922
GO:0021520
GO:0021522
GO:0021524
GO:0021559
GO:0021983
GO:0023052
GO:0030154
GO:0030182
GO:0030331
GO:0031016
GO:0031290
GO:0031333
GO:0032024
GO:0032725
GO:0032729
GO:0032730
GO:0032731
GO:0032735
GO:0032755
GO:0032760
GO:0033147
GO:0036211
GO:0042531
GO:0043226
GO:0043425
GO:0043524
GO:0043565
GO:0045597
GO:0045665
GO:0045766
GO:0045944
GO:0046872
GO:0048663
GO:0048665
GO:0048762
GO:0048856
GO:0048863
GO:0048870
GO:0048880
GO:0048935
GO:0048936
GO:0050728
GO:0055010
GO:0060037
GO:0060070
GO:0060379
GO:0060384
GO:0060413
GO:0060913
GO:0060931
GO:0061629
GO:0065003
GO:0071385
GO:0071657
GO:0086091
GO:0090090
GO:0140110
GO:1901258
GO:1990837
GO:1990841
HMNXSV003001258
ILMN_1763390
PH_hs_0000061
TC05000212.hg
U07559_at
g4504736_3p_at
Participates
as an output of
Expression of ISL1 in cardiogenesis (Homo sapiens)
as a component of
ISL1:LDB1 [nucleoplasm] (Homo sapiens)
GATA4:ISL1:LDB1:NKX2-5:TBX20:MEF2C gene [nucleoplasm] (Homo sapiens)
ISL1:LHX3:LDB1 [nucleoplasm] (Homo sapiens)
ISL1:LHX4:LDB1 [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
Synthesis of prepro-Glucose-dependent Insulinotropic Polypeptide (preproGIP) in intestinal K cells
(Homo sapiens)
Cross References
RefSeq
NP_002193.2
OpenTargets
ENSG00000016082
HPA
ENSG00000016082-ISL1
GeneCards
P61371
Ensembl
ENST00000230658
,
ENSG00000016082
,
ENSP00000230658
PRO
P61371
Pharos - Targets
P61371
Orphanet
23237
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8NB15 ZN511
0.781
7
UniProt:Q969G2 LHX4
1
LHX4 [nucleoplasm]
(R-HSA-9010585)
0.745
4
UniProt:Q9BWG4 SSBP4
0.659
4
UniProt:Q96PV0 SYNGAP1
1
SYNGAP1 [cytosol]
(R-HSA-5658217)
0.623
8
UniProt:Q86U70-2 LDB1
0.556
7
UniProt:P25377 ADH7
0.556
3
UniProt:P81877 SSBP2
0.527
2
UniProt:Q9Y4X5 ARIH1
1
ARIH1 [cytosol]
(R-HSA-1678825)
0.527
2
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