Interaction of PECAM-1 and SHP-1

Stable Identifier
R-HSA-210277
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Interaction of PECAM-1 and SHP-1
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The phosphorylation of two tandem tyrosine residues (Y663 and Y686) within the cytoplasmic domain of PECAM-1 is required for the downstream signalling events observed following PECAM-1 ligation. Both SH2 domains of SHP-1 are required in tandem to bind PECAM-1.

Literature References
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
Interaction of PECAM-1 and SHP-1 (Bos taurus)
Interaction of PECAM-1 and SHP-1 (Caenorhabditis elegans)
Interaction of PECAM-1 and SHP-1 (Canis familiaris)
Interaction of PECAM-1 and SHP-1 (Danio rerio)
Interaction of PECAM-1 and SHP-1 (Mus musculus)
Interaction of PECAM-1 and SHP-1 (Sus scrofa)
Interaction of PECAM-1 and SHP-1 (Xenopus tropicalis)
Authored
de Bono, B  (2008-02-26)
Garapati, P V  (2008-02-26)
Reviewed
Trowsdale, J  (2008-02-26)
Created
Garapati, P V  (2008-01-10)