Reactome | PTPN6,PTPN11 [cytosol]

PTPN6,PTPN11 [cytosol]

Stable Identifier

R-HSA-389744

Type

Set [DefinedSet]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SHP-2,SHP-1, SHP1,SHP2

Locations in the PathwayBrowser

Expand all

Participants

members

Participates

as an input of

as a component of

p-Y428,Y452,Y469,Y495-SIRPA:PTPN6,PTPN11 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
SHP-1/SHP-2:pBTLA:HVEM [plasma membrane] (Homo sapiens)
G6B:PTPN6,PTPN11 [plasma membrane] (Homo sapiens)

This entity regulates

Negatively

Phosphorylation of STAT1 (Homo sapiens)

Inferred To

PTPN6,PTPN11 [cytosol] (Bos taurus)

PTPN6,PTPN11 [cytosol] (Canis familiaris)

PTPN6,PTPN11 [cytosol] (Gallus gallus)

PTPN6,PTPN11 [cytosol] (Mus musculus)

PTPN6,PTPN11 [cytosol] (Rattus norvegicus)

PTPN6,PTPN11 [cytosol] (Sus scrofa)

PTPN6,PTPN11 [cytosol] (Xenopus tropicalis)

ptpn6 [cytosol] (Danio rerio)

csw [cytosol] (Drosophila melanogaster)

ptp-2 [cytosol] (Caenorhabditis elegans)

© 2022 Reactome

Cite Us!