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PTPN6,PTPN11 [cytosol]
Stable Identifier
R-HSA-389744
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SHP-2,SHP-1, SHP1,SHP2
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Signal regulatory protein family interactions (Homo sapiens)
p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
p-Y429,Y453,Y470,Y496-SIRPA:PTPN6,PTPN11 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
Phosphorylation of STAT1 (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
G6B binds PTPN6,PTPN11 (Homo sapiens)
G6B:PTPN6,PTPN11 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
SYK autophosphorylates (Homo sapiens)
G6B:PTPN6,PTPN11 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
p-Y7-CLEC1B dimer:PDPN binds SYK (Homo sapiens)
G6B:PTPN6,PTPN11 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-inhibition by BTLA (Homo sapiens)
SHP-1 and SHP-2 bind pBTLA (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
SHP-1/SHP-2:pBTLA:HVEM [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
Co-inhibition by PD-1 (Homo sapiens)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
Interaction of SHP-1 or SHP-2 with phospho PD-1 (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Interferon alpha/beta signaling (Homo sapiens)
Phosphorylation of STAT1 (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
SHP1 and SHP2 bind the common beta chain (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
Participants
members
PTPN6 [cytosol]
(Homo sapiens)
PTPN11 [cytosol]
(Homo sapiens)
Participates
as an input of
G6B binds PTPN6,PTPN11 (Homo sapiens)
p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 (Homo sapiens)
SHP1 and SHP2 bind the common beta chain (Homo sapiens)
SHP-1 and SHP-2 bind pBTLA (Homo sapiens)
Interaction of SHP-1 or SHP-2 with phospho PD-1 (Homo sapiens)
as a component of
p-Y429,Y453,Y470,Y496-SIRPA:PTPN6,PTPN11 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
SHP-1/SHP-2:pBTLA:HVEM [plasma membrane] (Homo sapiens)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
G6B:PTPN6,PTPN11 [plasma membrane] (Homo sapiens)
This entity regulates
Negatively
Phosphorylation of STAT1
(Homo sapiens)
Inferred To
PTPN6,PTPN11 [cytosol]
(Bos taurus)
PTPN6,PTPN11 [cytosol]
(Canis familiaris)
PTPN6,PTPN11 [cytosol]
(Gallus gallus)
PTPN6,PTPN11 [cytosol]
(Mus musculus)
PTPN6,PTPN11 [cytosol]
(Rattus norvegicus)
PTPN6,PTPN11 [cytosol]
(Sus scrofa)
PTPN11 [cytosol]
(Xenopus tropicalis)
ptp-2 [cytosol]
(Caenorhabditis elegans)
PTPN6 [cytosol]
(Drosophila melanogaster)
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