Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
Search ...
Go!
PTPN6,PTPN11
Stable Identifier
R-HSA-389744
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SHP-2,SHP-1, SHP1,SHP2
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Signal regulatory protein family interactions (Homo sapiens)
p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
p-Y428,Y452,Y469,Y495-SIRPA:PTPN6,PTPN11 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
G6B binds PTPN6,PTPN11 (Homo sapiens)
G6B:PTPN6,PTPN11 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
SYK autophosphorylates (Homo sapiens)
G6B:PTPN6,PTPN11 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
p-Y7-CLEC1B dimer:PDPN binds SYK (Homo sapiens)
G6B:PTPN6,PTPN11 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
PD-1 signaling (Homo sapiens)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
Interaction of SHP-1 or SHP-2 with phospho PD-1 (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
SHP-1 and SHP-2 bind pBTLA (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
SHP-1/SHP-2:pBTLA:HVEM [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Interferon alpha/beta signaling (Homo sapiens)
Phosphorylation of STAT1 (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
SHP1 and SHP2 bind the common beta chain (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
Participants
members
PTPN6 [cytosol] (Homo sapiens)
PTPN11 [cytosol] (Homo sapiens)
Participant Of
input
G6B binds PTPN6,PTPN11
Interaction of SHP-1 or SHP-2 with phospho PD-1
p-4Y-SIRPA:CD47 binds PTPN6,PTPN11
SHP-1 and SHP-2 bind pBTLA
SHP1 and SHP2 bind the common beta chain
hasComponent
G6B:PTPN6,PTPN11 [plasma membrane]
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane]
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane]
p-Y428,Y452,Y469,Y495-SIRPA:PTPN6,PTPN11 [plasma membrane]
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane]
SHP-1/SHP-2:pBTLA:HVEM [plasma membrane]
This entity regulates
Negative Regulation
Negative regulation by 'PTPN6,PTPN11 [cytosol]'
Inferred To
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN6,PTPN11 [cytosol] (Caenorhabditis elegans)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Danio rerio)
PTPN6,PTPN11 [cytosol] (Dictyostelium discoideum)
PTPN6,PTPN11 [cytosol] (Gallus gallus)
PTPN6,PTPN11 [cytosol] (Mus musculus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Saccharomyces cerevisiae)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Taeniopygia guttata)
PTPN6,PTPN11 [cytosol] (Xenopus tropicalis)
PTPN11 [cytosol] (Drosophila melanogaster)
© 2018
Reactome
