PTPN6,PTPN11

Participants

members

• PTPN6 [cytosol] (Homo sapiens)
• PTPN11 [cytosol] (Homo sapiens)

Participant Of

input

• G6B binds PTPN6,PTPN11
• Interaction of SHP-1 or SHP-2 with phospho PD-1
• p-4Y-SIRPA:CD47 binds PTPN6,PTPN11
• SHP-1 and SHP-2 bind pBTLA
• SHP1 and SHP2 bind the common beta chain

hasComponent

• G6B:PTPN6,PTPN11 [plasma membrane]
• High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane]
• High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane]
• p-Y428,Y452,Y469,Y495-SIRPA:PTPN6,PTPN11 [plasma membrane]
• PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane]
• SHP-1/SHP-2:pBTLA:HVEM [plasma membrane]

This entity regulates

Negatively

• Phosphorylation of STAT1

Inferred To

PTPN6,PTPN11 [cytosol] (Bos taurus)

PTPN6,PTPN11 [cytosol] (Caenorhabditis elegans)

PTPN6,PTPN11 [cytosol] (Canis familiaris)

PTPN6,PTPN11 [cytosol] (Danio rerio)

PTPN6,PTPN11 [cytosol] (Dictyostelium discoideum)

PTPN6,PTPN11 [cytosol] (Gallus gallus)

PTPN6,PTPN11 [cytosol] (Mus musculus)

PTPN6,PTPN11 [cytosol] (Rattus norvegicus)

PTPN6,PTPN11 [cytosol] (Saccharomyces cerevisiae)

PTPN6,PTPN11 [cytosol] (Sus scrofa)

PTPN6,PTPN11 [cytosol] (Taeniopygia guttata)

PTPN6,PTPN11 [cytosol] (Xenopus tropicalis)

PTPN11 [cytosol] (Drosophila melanogaster)