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PTPN6,PTPN11
Stable Identifier
R-HSA-389744
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SHP-2,SHP-1, SHP1,SHP2
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Signal regulatory protein family interactions (Homo sapiens)
p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
p-Y428,Y452,Y469,Y495-SIRPA:PTPN6,PTPN11 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
G6B binds PTPN6,PTPN11 (Homo sapiens)
G6B:PTPN6,PTPN11 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
SYK autophosphorylates (Homo sapiens)
G6B:PTPN6,PTPN11 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
p-Y7-CLEC1B dimer:PDPN binds SYK (Homo sapiens)
G6B:PTPN6,PTPN11 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
PD-1 signaling (Homo sapiens)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
Interaction of SHP-1 or SHP-2 with phospho PD-1 (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
SHP-1 and SHP-2 bind pBTLA (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
SHP-1/SHP-2:pBTLA:HVEM [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Interferon alpha/beta signaling (Homo sapiens)
Phosphorylation of STAT1 (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
SHP1 and SHP2 bind the common beta chain (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
Participants
members
PTPN6 [cytosol] (Homo sapiens)
PTPN11 [cytosol] (Homo sapiens)
Participant Of
input
G6B binds PTPN6,PTPN11
Interaction of SHP-1 or SHP-2 with phospho PD-1
p-4Y-SIRPA:CD47 binds PTPN6,PTPN11
SHP-1 and SHP-2 bind pBTLA
SHP1 and SHP2 bind the common beta chain
hasComponent
G6B:PTPN6,PTPN11 [plasma membrane]
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane]
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane]
p-Y428,Y452,Y469,Y495-SIRPA:PTPN6,PTPN11 [plasma membrane]
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane]
SHP-1/SHP-2:pBTLA:HVEM [plasma membrane]
This entity regulates
Negative Regulation
Negative regulation by 'PTPN6,PTPN11 [cytosol]'
Inferred To
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN6,PTPN11 [cytosol] (Caenorhabditis elegans)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Danio rerio)
PTPN6,PTPN11 [cytosol] (Dictyostelium discoideum)
PTPN6,PTPN11 [cytosol] (Gallus gallus)
PTPN6,PTPN11 [cytosol] (Mus musculus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Saccharomyces cerevisiae)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Taeniopygia guttata)
PTPN6,PTPN11 [cytosol] (Xenopus tropicalis)
PTPN6 [cytosol] (Drosophila melanogaster)
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