Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
KIR2DL3 [plasma membrane]
Stable Identifier
R-HSA-3006532
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Killer cell immunoglobulin-like receptor 2DL3, KI2L3_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
KIR2DL2/3 interacting with HLA-C group 1 (Cw4) (Homo sapiens)
HLA-C group 1 interacting with KIR2DL2/3 [plasma membrane] (Homo sapiens)
HLA-C group-I-interacting KIRs [plasma membrane] (Homo sapiens)
KIR2DL3 [plasma membrane] (Homo sapiens)
HLA-C group-I-interacting KIRs [plasma membrane] (Homo sapiens)
KIR2DL3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P43628 KIR2DL3
Gene Names
KIR2DL3, CD158B2, KIRCL23, NKAT2
Chain
signal peptide:1-21, chain:22-341
Reference Genes
BioGPS Gene:3804 KIR2DL3
COSMIC (genes):KIR2DL3 KIR2DL3
CTD Gene:3804 KIR2DL3
dbSNP Gene:3804 KIR2DL3
ENSEMBL:ENSG00000243772 KIR2DL3
ENSEMBL_homo_sapiens_GENE:ENSG00000243772.8 KIR2DL3
ENSEMBL_homo_sapiens_GENE:ENSG00000273887.1 KIR2DL3
ENSEMBL_homo_sapiens_GENE:ENSG00000274108.5 KIR2DL3
ENSEMBL_homo_sapiens_GENE:ENSG00000274402.1 KIR2DL3
ENSEMBL_homo_sapiens_GENE:ENSG00000274410.5 KIR2DL3
ENSEMBL_homo_sapiens_GENE:ENSG00000274830.5 KIR2DL3
ENSEMBL_homo_sapiens_GENE:ENSG00000274952.5 KIR2DL3
ENSEMBL_homo_sapiens_GENE:ENSG00000275008.1 KIR2DL3
ENSEMBL_homo_sapiens_GENE:ENSG00000275623.5 KIR2DL3
ENSEMBL_homo_sapiens_GENE:ENSG00000275658.5 KIR2DL3
ENSEMBL_homo_sapiens_GENE:ENSG00000276218.5 KIR2DL3
ENSEMBL_homo_sapiens_GENE:ENSG00000276459.5 KIR2DL3
ENSEMBL_homo_sapiens_GENE:ENSG00000276590.5 KIR2DL3
ENSEMBL_homo_sapiens_GENE:ENSG00000277317.5 KIR2DL3
ENSEMBL_homo_sapiens_GENE:ENSG00000277484.5 KIR2DL3
ENSEMBL_homo_sapiens_GENE:ENSG00000277554.5 KIR2DL3
ENSEMBL_homo_sapiens_GENE:ENSG00000277924.5 KIR2DL3
ENSEMBL_homo_sapiens_GENE:ENSG00000278327.5 KIR2DL3
ENSEMBL_homo_sapiens_GENE:ENSG00000283702.2 KIR2DL3
ENSEMBL_homo_sapiens_GENE:ENSG00000283708.2 KIR2DL3
ENSEMBL_homo_sapiens_GENE:ENSG00000283790.2 KIR2DL3
ENSEMBL_homo_sapiens_GENE:ENSG00000284333.2 KIR2DL3
ENSEMBL_homo_sapiens_GENE:ENSG00000284504.2 KIR2DL3
ENSEMBL_homo_sapiens_GENE:ENSG00000284510.2 KIR2DL3
HGNC:6331 KIR2DL3
KEGG Gene (Homo sapiens):3804 KIR2DL3
Monarch:3804 KIR2DL3
NCBI Gene:3804 KIR2DL3
OMIM:604938 KIR2DL3
UCSC:P43628 KIR2DL3
Reference Transcript
RefSeq:NM_015868.2 KIR2DL3
Other Identifiers
11742301_x_at
16865470
16876286
208179_PM_x_at
208179_x_at
31780_f_at
36886_f_at
36887_f_at
3804
3841708
3841715
3841717
3841719
3841720
3841721
3841723
3841724
3841725
3841726
3841728
3841729
3841730
3841731
3841732
3841734
3841735
3841737
3841740
3841742
3841743
3841746
3841747
3841749
3841750
3841751
3841753
3841755
3841757
3841760
3841763
3841766
3841768
3841769
3841774
3841775
3841776
3841778
3841782
3841785
3841809
3841811
3841814
3841819
3841824
3841829
3841834
3841836
3841837
3841841
3841843
3841845
3841846
3841849
3841851
3841854
3841858
4052951
4052957
4052958
4052961
4052963
4052965
4052968
4052969
4052970
4052971
4052975
4052976
4052977
4052978
4052992
4052996
4052997
4052998
4053003
4053005
4053009
4053021
4053022
4053023
4053026
4053027
4053045
4053046
4053047
4053048
4053049
4053050
4053052
4053058
4053061
4053062
4053063
4053064
4053065
4053066
4053067
4053069
4053075
8031277
8031293
8031297
8039829
8039842
8039896
GE510478
GO:0002376
GO:0003823
GO:0005515
GO:0005886
GO:0006955
GO:0016020
GO:0038023
GO:0042802
GO:0060089
HMNXSV003001861
ILMN_1667232
L41268_f_at
PH_hs_0029293
PH_hs_0030678
PH_hs_0034336
PH_hs_0039926
TC19002236.hg
TC19002661.hg
X97230_f_at
g2760896_3p_x_at
Participates
as a member of
HLA-C group-I-interacting KIRs [plasma membrane] (Homo sapiens)
Inferred To
KIR2DL1 [plasma membrane]
(Bos taurus)
KIR2DL1 [plasma membrane]
(Sus scrofa)
KIR3DL2 [plasma membrane]
(Bos taurus)
KIR2DL3 [plasma membrane]
(Bos taurus)
Kir3dl2 [plasma membrane]
(Mus musculus)
KIR2DS1 [plasma membrane]
(Bos taurus)
Kir3dl1 [plasma membrane]
(Mus musculus)
Kir3dl1 [plasma membrane]
(Rattus norvegicus)
LOC100852061 [plasma membrane]
(Bos taurus)
Homologues of KIR2DL3 [plasma membrane]
(Bos taurus)
Homologues of KIR2DL3 [plasma membrane]
(Mus musculus)
KIR3DL1 [plasma membrane]
(Bos taurus)
KIR3DS1 [plasma membrane]
(Bos taurus)
Cross References
RefSeq
NP_056952.2
OpenTargets
ENSG00000243772
GeneCards
P43628
HPA
ENSG00000243772-KIR2DL3
Ensembl
ENSG00000277317
,
ENSG00000277554
,
ENST00000640485
,
ENSG00000284510
,
ENSP00000478657
,
ENST00000611990
,
ENSG00000275008
,
ENSG00000276459
,
ENSG00000277924
,
ENSP00000491452
,
ENST00000610407
,
ENST00000620549
,
ENSP00000491955
,
ENST00000611207
,
ENST00000611369
,
ENSP00000478848
,
ENSP00000342215
,
ENST00000611821
,
ENSG00000283790
,
ENST00000638851
,
ENSG00000274108
,
ENST00000617404
,
ENSG00000243772
,
ENSP00000491264
,
ENSG00000274830
,
ENST00000638813
,
ENSP00000479121
,
ENSP00000492856
,
ENSP00000484459
,
ENSG00000276590
,
ENSP00000481237
,
ENSG00000284504
,
ENSP00000483419
,
ENSP00000480464
,
ENSP00000483975
,
ENST00000617790
,
ENSG00000274402
,
ENSG00000283702
,
ENSP00000481478
,
ENSG00000275658
,
ENST00000617242
,
ENST00000619995
,
ENSG00000276218
,
ENST00000639176
,
ENST00000622644
,
ENSP00000478136
,
ENST00000615739
,
ENSP00000483192
,
ENST00000614792
,
ENSG00000273887
,
ENSG00000284333
,
ENST00000639089
,
ENSP00000492356
,
ENSG00000278327
,
ENSP00000483883
,
ENSP00000480087
,
ENST00000342376
,
ENST00000619702
,
ENSP00000482830
,
ENSG00000283708
,
ENSP00000483551
,
ENSG00000277484
,
ENSG00000274410
,
ENSG00000275623
,
ENSG00000274952
,
ENSP00000481159
,
ENST00000617150
,
ENST00000639101
,
ENSP00000481355
,
ENST00000617593
,
ENST00000615091
,
ENSP00000491273
PRO
P43628
Pharos - Targets
P43628
PDB
1B6U
,
8TUI
,
6PAG
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P29350 PTPN6
5
PTPN6 [tertiary granule lumen]
(R-HSA-6800952)
PTPN6 [extracellular region]
(R-HSA-6806315)
PTPN6 [specific granule lumen]
(R-HSA-6799641)
PTPN6 [nucleoplasm]
(R-HSA-9008911)
PTPN6 [cytosol]
(R-HSA-197938)
0.824
13
UniProt:O43561-2 LAT
2
p-5Y-LAT-2 [plasma membrane]
(R-HSA-2396597)
LAT-2 [plasma membrane]
(R-HSA-2396548)
0.556
3
UniProt:Q8N661 TMEM86B
1
TMEM86B [endoplasmic reticulum membrane]
(R-HSA-8874443)
0.556
3
UniProt:A8MZ59 LEUTX
1
LEUTX [nucleoplasm]
(R-HSA-9817277)
0.556
3
UniProt:O15342 ATP6V0E1
3
ATP6V0E1 [endosome membrane]
(R-HSA-912582)
ATP6V0E1 [phagocytic vesicle membrane]
(R-HSA-1222533)
ATP6V0E1 [lysosomal membrane]
(R-HSA-9640180)
0.556
3
UniProt:O75396 SEC22B
6
SEC22B [endoplasmic reticulum membrane]
(R-HSA-5688150)
SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688566)
SEC22B [ER to Golgi transport vesicle membrane]
(R-HSA-5688565)
SEC22B [phagocytic vesicle membrane]
(R-HSA-8863938)
SEC22B [transport vesicle]
(R-HSA-6810994)
SEC22B [Golgi membrane]
(R-HSA-6810993)
0.556
3
UniProt:P01350 GAST
1
GAST(76-92) [extracellular region]
(R-HSA-870266)
0.556
3
UniProt:P07204 THBD
1
THBD [plasma membrane]
(R-HSA-141030)
0.556
3
UniProt:P05090 APOD
1
APOD [extracellular region]
(R-HSA-5216199)
0.556
3
UniProt:Q5QGT7 RTP2
2
RTP2 [endoplasmic reticulum membrane]
(R-HSA-9752982)
RTP2 [plasma membrane]
(R-HSA-8939446)
0.556
3
UniProt:P02652 APOA2
6
APOA2(24-100) [cytosol]
(R-HSA-2395772)
APOA2(24-100) [early endosome]
(R-HSA-2569092)
APOA2(24-100) [endoplasmic reticulum lumen]
(R-HSA-174689)
APOA2(24-100) [extracellular region]
(R-HSA-174775)
p-APOA2 [endoplasmic reticulum lumen]
(R-HSA-8957014)
APOA2 [endoplasmic reticulum lumen]
(R-HSA-8956780)
0.556
3
UniProt:Q8N8N0 RNF152
1
RNF152 [lysosomal membrane]
(R-HSA-8938832)
0.556
3
UniProt:Q8WVV5 BTN2A2
1
BTN2A2 [plasma membrane]
(R-HSA-8851047)
0.556
3
UniProt:Q01628 IFITM3
1
IFITM3 [plasma membrane]
(R-HSA-1015688)
0.556
3
UniProt:Q06124 PTPN11
4
p-Y542-PTPN11 [cytosol]
(R-HSA-1369081)
PTPN11 [nucleoplasm]
(R-HSA-8937745)
PTPN11 [cytosol]
(R-HSA-162563)
p-Y542,Y580-PTPN11 [cytosol]
(R-HSA-162573)
0.462
4
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
