Reactome | Interaction of SHP1 and KIT

Interaction of SHP1 and KIT

Stable Identifier

R-HSA-205306

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region, cytosol

ReviewStatus

5/5

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The protein tyrosine phosphatase SHP-1 negatively regulates KIT signaling through binding to phosphorylated Y570. It is unclear whether SHP1 directly dephosphorylates KIT or elicits dephosphorylation of the receptor indirectly by dephosphorylating and inhibiting cytosolic PTKs that act on KIT. SHP-1 may also compete with and displace SFKs or other proteins that dock to phosphorylated Y570 (Kozlowski et al, 1998).

Literature References

PubMed ID	Title	Journal	Year
7684496	Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand Yi, T, Ihle, JN	Mol Cell Biol	1993
9528781	SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain Rottapel, R, Larose, L, Siminovitch, KA, Le, DM, Lee, F, Kozlowski, M	Mol Cell Biol	1998
16129412	Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor Roskoski, R Jr	Biochem Biophys Res Commun	2005