Interaction of SHP1 and KIT

Stable Identifier
R-HSA-205306
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane, extracellular region, cytosol
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Interaction of SHP1 and KIT
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The protein tyrosine phosphatase SHP-1 negatively regulates KIT signaling through binding to phosphorylated Y570. It is unclear whether SHP1 directly dephosphorylates KIT or elicits dephosphorylation of the receptor indirectly by dephosphorylating and inhibiting cytosolic PTKs that act on KIT. SHP-1 may also compete with and displace SFKs or other proteins that dock to phosphorylated Y570 (Kozlowski et al, 1998).

Literature References
PubMed ID Title Journal Year
7684496 Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand

Yi, T, Ihle, JN

Mol Cell Biol 1993
9528781 SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain

Rottapel, R, Larose, L, Siminovitch, KA, Le, DM, Lee, F, Kozlowski, M

Mol Cell Biol 1998
16129412 Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor

Roskoski, R Jr

Biochem Biophys Res Commun 2005
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Orthologous Events
Interaction of SHP1 and KIT (Canis familiaris)
Interaction of SHP1 and KIT (Danio rerio)
Interaction of SHP1 and KIT (Mus musculus)
Interaction of SHP1 and KIT (Rattus norvegicus)
Interaction of SHP1 and KIT (Sus scrofa)
Authored
Garapati, P V  (2011-07-11)
Reviewed
Rönnstrand, L  (2011-08-22)
Created
Garapati, P V  (2007-12-10)
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