Interaction of SHP1 and KIT

Stable Identifier
R-HSA-205306
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The protein tyrosine phosphatase SHP-1 negatively regulates KIT signaling through binding to phosphorylated Y570. It is unclear whether SHP1 directly dephosphorylates KIT or elicits dephosphorylation of the receptor indirectly by dephosphorylating and inhibiting cytosolic PTKs that act on KIT. SHP-1 may also compete with and displace SFKs or other proteins that dock to phosphorylated Y570 (Kozlowski et al, 1998).

Literature References
PubMed ID Title Journal Year
9528781 SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain

Kozlowski, M, Larose, L, Lee, F, Le, DM, Rottapel, R, Siminovitch, KA

Mol Cell Biol 1998
7684496 Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand

Yi, T, Ihle, JN

Mol Cell Biol 1993
16129412 Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor

Roskoski, R Jr

Biochem Biophys Res Commun 2005
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