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PTPN6 [cytosol]
Stable Identifier
R-SSC-197938
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
PTPN6, A0A480TLF2
Locations in the PathwayBrowser
Expand all
Hemostasis (Sus scrofa)
Cell surface interactions at the vascular wall (Sus scrofa)
PECAM1 interactions (Sus scrofa)
Interaction of PECAM-1 and SHP-1 (Sus scrofa)
PECAM-1:SHP-1 complex [plasma membrane] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Platelet activation, signaling and aggregation (Sus scrofa)
GPVI-mediated activation cascade (Sus scrofa)
G6B binds PTPN6,PTPN11 (Sus scrofa)
G6B:PTPN6,PTPN11 [plasma membrane] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
SYK autophosphorylates (Sus scrofa)
G6B:PTPN6,PTPN11 [plasma membrane] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
p-Y7-CLEC1B dimer:PDPN binds SYK (Sus scrofa)
G6B:PTPN6,PTPN11 [plasma membrane] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Platelet homeostasis (Sus scrofa)
Platelet sensitization by LDL (Sus scrofa)
Interaction of PECAM-1 and SHP-1 (Sus scrofa)
PECAM-1:SHP-1 complex [plasma membrane] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
Regulation of T cell activation by CD28 family (Sus scrofa)
Co-inhibition by PD-1 (Sus scrofa)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Interaction of SHP-1 or SHP-2 with phospho PD-1 (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Signaling by the B Cell Receptor (BCR) (Sus scrofa)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Sus scrofa)
SYK autophosphorylates at the activated BCR (Sus scrofa)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
CD22 mediated BCR regulation (Sus scrofa)
SHP1 binds p-CD22 (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Cytokine Signaling in Immune system (Sus scrofa)
Interferon Signaling (Sus scrofa)
Interferon alpha/beta signaling (Sus scrofa)
Regulation of IFNA/IFNB signaling (Sus scrofa)
Dephosphorylation of JAK1 by SHP1 (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Interferon gamma signaling (Sus scrofa)
Transphosphorylation of JAK1 (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Signaling by Interleukins (Sus scrofa)
Interleukin-2 family signaling (Sus scrofa)
Interleukin receptor SHC signaling (Sus scrofa)
The SHC1:SHIP1 complex is stabilized by GRB2 (Sus scrofa)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Sus scrofa)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Sus scrofa)
Interleukin receptor SHC signaling (Sus scrofa)
The SHC1:SHIP1 complex is stabilized by GRB2 (Sus scrofa)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Sus scrofa)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
SHP1 and SHP2 bind the common beta chain (Sus scrofa)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Sus scrofa)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by ALK (Sus scrofa)
PTPN6 dephosphorylates JAK3 (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Signaling by SCF-KIT (Sus scrofa)
Regulation of KIT signaling (Sus scrofa)
Interaction of SHP1 and KIT (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
PTPN6:p-c-Kit complex [plasma membrane] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A480TLF2
Gene Names
PTPN6
Reference Genes
BioGPS Gene:100171389 PTPN6
ENSEMBL:ENSSSCG00000025537.4
Monarch:100171389 PTPN6
NCBI Gene:100171389 PTPN6
UCSC:A0A480TLF2 PTPN6
Reference Transcript
RefSeq:XM_005652593.2 PTPN6
Participates
as an input of
SHP1 binds p-CD22 (Sus scrofa)
Interaction of SHP1 and KIT (Sus scrofa)
Interaction of PECAM-1 and SHP-1 (Sus scrofa)
as a component of
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Sus scrofa)
PTPN6:p-c-Kit complex [plasma membrane] (Sus scrofa)
PECAM-1:SHP-1 complex [plasma membrane] (Sus scrofa)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Sus scrofa)
as a member of
PTPN6,PTPN11 [cytosol] (Sus scrofa)
This entity regulates
Negatively
Transphosphorylation of JAK1
(Sus scrofa)
Other forms of this molecule
PTPN6 [tertiary granule lumen]
PTPN6 [extracellular region]
PTPN6 [specific granule lumen]
Inferred From
PTPN6 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_005652650.1
VGNC
91982
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