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PTPN6 [cytosol]
Stable Identifier
R-SSC-197938
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
A0A4X1UZH9
Locations in the PathwayBrowser
Expand all
Hemostasis (Sus scrofa)
Cell surface interactions at the vascular wall (Sus scrofa)
PECAM1 interactions (Sus scrofa)
Interaction of PECAM-1 and SHP-1 (Sus scrofa)
PECAM-1:SHP-1 complex [plasma membrane] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Platelet activation, signaling and aggregation (Sus scrofa)
GPVI-mediated activation cascade (Sus scrofa)
G6B binds PTPN6,PTPN11 (Sus scrofa)
G6B:PTPN6,PTPN11 [plasma membrane] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
p-Y7-CLEC1B dimer:PDPN binds SYK (Sus scrofa)
G6B:PTPN6,PTPN11 [plasma membrane] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Platelet homeostasis (Sus scrofa)
Platelet sensitization by LDL (Sus scrofa)
Interaction of PECAM-1 and SHP-1 (Sus scrofa)
PECAM-1:SHP-1 complex [plasma membrane] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
Regulation of T cell activation by CD28 family (Sus scrofa)
Co-inhibition by PD-1 (Sus scrofa)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Interaction of SHP-1 or SHP-2 with phospho PD-1 (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Signaling by the B Cell Receptor (BCR) (Sus scrofa)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Sus scrofa)
SYK autophosphorylates at the activated BCR (Sus scrofa)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
CD22 mediated BCR regulation (Sus scrofa)
SHP1 binds p-CD22 (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Cytokine Signaling in Immune system (Sus scrofa)
Interferon Signaling (Sus scrofa)
Interferon alpha/beta signaling (Sus scrofa)
Regulation of IFNA/IFNB signaling (Sus scrofa)
Dephosphorylation of JAK1 by SHP1 (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Interferon gamma signaling (Sus scrofa)
Transphosphorylation of JAK1 (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Signaling by Interleukins (Sus scrofa)
Interleukin-2 family signaling (Sus scrofa)
Interleukin receptor SHC signaling (Sus scrofa)
The SHC1:SHIP1 complex is stabilized by GRB2 (Sus scrofa)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Sus scrofa)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Sus scrofa)
Interleukin receptor SHC signaling (Sus scrofa)
The SHC1:SHIP1 complex is stabilized by GRB2 (Sus scrofa)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Sus scrofa)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
SHP1 and SHP2 bind the common beta chain (Sus scrofa)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Sus scrofa)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
PTPN6,PTPN11 [cytosol] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by ALK (Sus scrofa)
PTPN6 dephosphorylates JAK3 (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
Signaling by SCF-KIT (Sus scrofa)
Regulation of KIT signaling (Sus scrofa)
Interaction of SHP1 and KIT (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
PTPN6:p-c-Kit complex [plasma membrane] (Sus scrofa)
PTPN6 [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A4X1UZH9
Reference Genes
BioGPS Gene:100171389
ENSEMBL:ENSSSCG00005025509.1
Monarch:100171389
NCBI Gene:100171389
UCSC:A0A4X1UZH9
Reference Transcript
RefSeq:XM_005652593.2
Other Identifiers
100171389
GO:0000165
GO:0000278
GO:0001784
GO:0002221
GO:0002244
GO:0002376
GO:0002753
GO:0002924
GO:0003824
GO:0004721
GO:0004725
GO:0004726
GO:0005001
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005886
GO:0005911
GO:0006470
GO:0006954
GO:0008284
GO:0016311
GO:0016525
GO:0016787
GO:0017124
GO:0019901
GO:0030154
GO:0030220
GO:0031665
GO:0032715
GO:0032720
GO:0032991
GO:0033007
GO:0033630
GO:0035556
GO:0035855
GO:0042098
GO:0042105
GO:0042110
GO:0042130
GO:0042169
GO:0042267
GO:0043409
GO:0045577
GO:0045766
GO:0045824
GO:0048856
GO:0050839
GO:0050852
GO:0050853
GO:0050859
GO:0050860
GO:0051279
GO:0051897
GO:0070372
GO:0070527
GO:0090594
GO:0106015
GO:0140031
GO:0140096
GO:0160162
GO:1900017
GO:1902564
GO:1905867
GO:2000045
Ssc.5530.2.S1_at
Ssc.5530.3.S1_at
Participates
as an input of
Interaction of SHP1 and KIT (Sus scrofa)
Interaction of PECAM-1 and SHP-1 (Sus scrofa)
SHP1 binds p-CD22 (Sus scrofa)
as a component of
PTPN6:p-c-Kit complex [plasma membrane] (Sus scrofa)
PECAM-1:SHP-1 complex [plasma membrane] (Sus scrofa)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Sus scrofa)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Sus scrofa)
as a member of
PTPN6,PTPN11 [cytosol] (Sus scrofa)
This entity regulates
Negatively
Transphosphorylation of JAK1
(Sus scrofa)
Other forms of this molecule
PTPN6 [specific granule lumen]
PTPN6 [extracellular region]
PTPN6 [tertiary granule lumen]
Inferred From
PTPN6 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_005652650.1
ENSEMBL
ENSSSCT00000054519
,
ENSSSCP00000045365
,
ENSSSCG00000025537
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