Reactome | Transphosphorylation of JAK1

Transphosphorylation of JAK1

Stable Identifier

R-HSA-873918

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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The initial phosphorylation of JAK1 and JAK2 is mediated by JAK2. Autophosphorylated JAK2 may transphopshorylate JAK1 bound to IFNGR1 chain. Tyrosine 1033 in the activation loop of the JAK1 kinase domain may be the target for transphosphorylation (phosphorylation site mentioned here is based on sequence similarity with all the other JAK kinases).

Literature References

PubMed ID	Title	Journal	Year
8631301	Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state Witthuhn, BA, Wilks, AF, Stark, GR, Watling, D, Kerr, IM, Briscoe, J, Rogers, NC, Harpur, AG, Ihle, JN	EMBO J	1996