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PTPN6 [cytosol]
Stable Identifier
R-BTA-197938
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
A0A3Q1M739
Locations in the PathwayBrowser
Expand all
Hemostasis (Bos taurus)
Cell surface interactions at the vascular wall (Bos taurus)
PECAM1 interactions (Bos taurus)
Interaction of PECAM-1 and SHP-1 (Bos taurus)
PECAM-1:SHP-1 complex [plasma membrane] (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
GPVI-mediated activation cascade (Bos taurus)
G6B binds PTPN6,PTPN11 (Bos taurus)
G6B:PTPN6,PTPN11 [plasma membrane] (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
SYK autophosphorylates (Bos taurus)
G6B:PTPN6,PTPN11 [plasma membrane] (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
p-Y7-CLEC1B dimer:PDPN binds SYK (Bos taurus)
G6B:PTPN6,PTPN11 [plasma membrane] (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
Platelet homeostasis (Bos taurus)
Platelet sensitization by LDL (Bos taurus)
Interaction of PECAM-1 and SHP-1 (Bos taurus)
PECAM-1:SHP-1 complex [plasma membrane] (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Costimulation by the CD28 family (Bos taurus)
PD-1 signaling (Bos taurus)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
Interaction of SHP-1 or SHP-2 with phospho PD-1 (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Bos taurus)
SYK autophosphorylates at the activated BCR (Bos taurus)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
CD22 mediated BCR regulation (Bos taurus)
SHP1 binds p-CD22 (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Interferon Signaling (Bos taurus)
Interferon alpha/beta signaling (Bos taurus)
Regulation of IFNA/IFNB signaling (Bos taurus)
Dephosphorylation of JAK1 by SHP1 (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
Interferon gamma signaling (Bos taurus)
Transphosphorylation of JAK1 (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-2 family signaling (Bos taurus)
Interleukin receptor SHC signaling (Bos taurus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Bos taurus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Bos taurus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Bos taurus)
Interleukin receptor SHC signaling (Bos taurus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Bos taurus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Bos taurus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
SHP1 and SHP2 bind the common beta chain (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
PTPN6,PTPN11 [cytosol] (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ALK (Bos taurus)
PTPN6 dephosphorylates JAK3 (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
Signaling by SCF-KIT (Bos taurus)
Regulation of KIT signaling (Bos taurus)
Interaction of SHP1 and KIT (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
PTPN6:p-c-Kit complex [plasma membrane] (Bos taurus)
PTPN6 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:A0A3Q1M739
Reference Genes
BioGPS Gene:512312
ENSEMBL:ENSBTAG00000020294.5
ENSEMBL:ENSBTAG00000020294.6
Monarch:512312
NCBI Gene:512312
Reference Transcript
RefSeq:XM_005207130.2
Other Identifiers
512312
GO:0000165
GO:0000278
GO:0001784
GO:0002244
GO:0002376
GO:0002924
GO:0003824
GO:0004721
GO:0004725
GO:0004726
GO:0005001
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005886
GO:0005911
GO:0006954
GO:0007155
GO:0008284
GO:0016311
GO:0016787
GO:0017124
GO:0019901
GO:0023052
GO:0030154
GO:0030220
GO:0032715
GO:0032720
GO:0032991
GO:0033007
GO:0033630
GO:0035556
GO:0035855
GO:0036211
GO:0042060
GO:0042098
GO:0042105
GO:0042130
GO:0042169
GO:0042267
GO:0043226
GO:0043409
GO:0045577
GO:0048856
GO:0050732
GO:0050839
GO:0050852
GO:0050853
GO:0050860
GO:0051279
GO:0051897
GO:0055065
GO:0055085
GO:0060089
GO:0070372
GO:0070527
GO:0071310
GO:0098542
GO:0106015
GO:0140031
GO:0140096
GO:1905867
GO:2000045
Participates
as an input of
Interaction of PECAM-1 and SHP-1 (Bos taurus)
Interaction of SHP1 and KIT (Bos taurus)
SHP1 binds p-CD22 (Bos taurus)
as a component of
PECAM-1:SHP-1 complex [plasma membrane] (Bos taurus)
PTPN6:p-c-Kit complex [plasma membrane] (Bos taurus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Bos taurus)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Bos taurus)
as a member of
PTPN6,PTPN11 [cytosol] (Bos taurus)
This entity regulates
Negatively
Transphosphorylation of JAK1
(Bos taurus)
Other forms of this molecule
PTPN6 [specific granule lumen]
PTPN6 [extracellular region]
PTPN6 [tertiary granule lumen]
Inferred From
PTPN6 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_005207187.1
Ensembl
ENSBTAT00000077529
,
ENSBTAG00000020294
,
ENSBTAP00000064215
VGNC
33541
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