Reactome | CD33 [specific granule membrane]

CD33 [specific granule membrane]

Stable Identifier

R-HSA-6799615

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

specific granule membrane

Synonyms

Myeloid cell surface antigen CD33 precursor, SIGLEC3

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P20138 CD33

Gene Names

CD33, SIGLEC3

Chain

signal peptide:1-17, chain:18-364

Reference Genes

BioGPS Gene:945 CD33

COSMIC (genes):CD33 CD33

CTD Gene:945 CD33

dbSNP Gene:945 CD33

ENSEMBL:ENSG00000105383 CD33

HGNC:1659 CD33

KEGG:hsa:945 CD33

Monarch:945 CD33

NCBI Gene:945 CD33

OMIM:159590 CD33

UCSC:P20138 CD33

Reference Transcript

Participates

as a member of

Specific granule membrane proteins [specific granule membrane] (Homo sapiens)

Other forms of this molecule

CD33 [plasma membrane]

CD33 [tertiary granule membrane]

Inferred To

LOC100686511 [specific granule membrane] (Canis familiaris)

LOC101884775 [specific granule membrane] (Danio rerio)

LOC100138951 [specific granule membrane] (Bos taurus)

LOC103910452 [specific granule membrane] (Danio rerio)

siglecl2 [specific granule membrane] (Xenopus tropicalis)

Homologues of CD33 [specific granule membrane] (Danio rerio)

Homologues of CD33 [specific granule membrane] (Xenopus tropicalis)

LOC110261034 [specific granule membrane] (Sus scrofa)

Siglec5 [specific granule membrane] (Mus musculus)

Siglec5 [specific granule membrane] (Rattus norvegicus)

bckdhbl [specific granule membrane] (Danio rerio)

XB5961956 [specific granule membrane] (Xenopus tropicalis)

Cross References

RefSeq

XP_011525834.1, NP_001076087.1, NP_001171079.1, NP_001763.3

Guide to Pharmacology - Targets

2601

OpenTargets

ENSG00000105383

ENSEMBL

ENST00000421133, ENST00000262262, ENSP00000262262, ENST00000391796, ENSG00000105383, ENSP00000410126, ENSP00000375673

HPA

ENSG00000105383-CD33

GeneCards

CD33

PRO

P20138

Pharos - Targets

P20138

GlyGen

P20138

HMDB Protein

HMDBP14336

PDB

6D4A, 6TL8, 5J0B, 7AW6, 5J06, 6D49, 6D48, 5IHB

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P29350 PTPN6	5	PTPN6 [cytosol] (R-HSA-197938) PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [tertiary granule lumen] (R-HSA-6800952) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [specific granule lumen] (R-HSA-6799641)	0.824	10
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.718	6
UniProt:Q06124 PTPN11	4	p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573) PTPN11 [cytosol] (R-HSA-162563) PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y542-PTPN11 [cytosol] (R-HSA-1369081)	0.677	5
UniProt:P40855 PEX19	1	PEX19 [cytosol] (R-HSA-3009036)	0.643	3
UniProt:Q9UBI1 COMMD3	4	COMMD3 [nucleoplasm] (R-HSA-8955108) COMMD3 [cytosol] (R-HSA-8955113) COMMD3 [extracellular region] (R-HSA-6806501) COMMD3 [ficolin-1-rich granule lumen] (R-HSA-6801405)	0.643	3
UniProt:Q8N1S5 S39AB			0.643	3
UniProt:P06702 S100A9	3	S100A9 [cytosol] (R-HSA-9626869) S100A9 [secretory granule lumen] (R-HSA-6804774) S100A9 [extracellular region] (R-HSA-5432857)	0.589	5
UniProt:O00767 SCD	1	SCD [endoplasmic reticulum membrane] (R-HSA-400117)	0.556	3
UniProt:O43169 CYB5B	2	CYB5B [endoplasmic reticulum membrane] (R-HSA-9842695) CYB5B [mitochondrial outer membrane] (R-HSA-8943390)	0.556	3
UniProt:Q9Y5Z9 UBIAD1	1	UBIAD1 [endoplasmic reticulum membrane] (R-HSA-2980965)	0.556	3
UniProt:Q9UPZ6 THSD7A	3	THSD7A [endoplasmic reticulum lumen] (R-HSA-5173009) glc-fuc-THSD7A [endoplasmic reticulum lumen] (R-HSA-5173197) O-fuc-THSD7A [endoplasmic reticulum lumen] (R-HSA-5173184)	0.556	3
UniProt:Q9NS64 RPRM			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q5BVD1 TTMP			0.556	3
UniProt:Q96F15 GIMA5			0.556	3
UniProt:Q9BU79 TM243			0.556	3
UniProt:P50402 EMD	4	EMD [nuclear envelope] (R-HSA-201573) EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [endosome membrane] (R-HSA-9715092)	0.556	3
UniProt:Q07325 CXCL9	1	CXCL9 [extracellular region] (R-HSA-373856)	0.556	3
UniProt:Q969X1 TMBIM1	2	TMBIM1 [specific granule membrane] (R-HSA-6799704) TMBIM1 [plasma membrane] (R-HSA-6800472)	0.556	3
UniProt:Q9H2S6-2 TNMD			0.556	3
UniProt:O95393 BMP10	2	BMP10(22-424) [extracellular region] (R-HSA-2396409) BMP10 [extracellular region] (R-HSA-8858374)	0.556	3
UniProt:Q92764 KRT35	1	KRT35 [cytosol] (R-HSA-6809595)	0.556	3
UniProt:Q9NV29 TM100			0.556	3
UniProt:P63316 TNNC1	1	TNNC1 [cytosol] (R-HSA-390533)	0.527	2

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