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CD33 [specific granule membrane]
Stable Identifier
R-HSA-6799615
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
specific granule membrane
Synonyms
Myeloid cell surface antigen CD33 precursor, SIGLEC3
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of specific granule membrane proteins (Homo sapiens)
Specific granule membrane proteins [specific granule membrane] (Homo sapiens)
CD33 [specific granule membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20138 CD33
Gene Names
CD33, SIGLEC3
Chain
signal peptide:1-17, chain:18-364
Reference Genes
BioGPS Gene:945 CD33
COSMIC (genes):CD33 CD33
CTD Gene:945 CD33
dbSNP Gene:945 CD33
ENSEMBL:ENSG00000105383 CD33
ENSEMBL:ENSG00000105383.15 CD33
HGNC:1659 CD33
KEGG Gene (Homo sapiens):945 CD33
Monarch:945 CD33
NCBI Gene:945 CD33
OMIM:159590 CD33
UCSC:P20138 CD33
Reference Transcript
RefSeq:NM_001177608.1 CD33
RefSeq:XM_011527532.2 CD33
RefSeq:NM_001082618.1 CD33
RefSeq:NM_001772.3 CD33
Other Identifiers
11740961_a_at
11748873_x_at
16864675
206120_PM_at
206120_at
36802_at
3839701
3839719
3839720
3839722
3839723
3839724
3839725
3839727
3839729
3839730
3839731
8030804
945
A_14_P137198
A_21_P0000094
A_24_P301655
GE57877
GO:0002376
GO:0002765
GO:0005515
GO:0005634
GO:0005654
GO:0005777
GO:0005794
GO:0005886
GO:0007155
GO:0007165
GO:0007267
GO:0008285
GO:0009897
GO:0009986
GO:0016020
GO:0019903
GO:0023052
GO:0030246
GO:0031410
GO:0032691
GO:0032717
GO:0032720
GO:0033691
GO:0035579
GO:0036211
GO:0038023
GO:0043226
GO:0050714
GO:0051926
GO:0060089
GO:0070821
GO:0098609
GO:0150102
GO:1903615
HMNXSV003004904
ILMN_1747622
M23197_at
PH_hs_0004774
TC19000775.hg
g4502654_3p_at
Participates
as a member of
Specific granule membrane proteins [specific granule membrane] (Homo sapiens)
Other forms of this molecule
CD33 [plasma membrane]
CD33 [tertiary granule membrane]
Inferred To
Siglech [specific granule membrane]
(Mus musculus)
LOC100138951 [specific granule membrane]
(Bos taurus)
LOC103910452 [specific granule membrane]
(Danio rerio)
Homologues of CD33 [specific granule membrane]
(Bos taurus)
Homologues of CD33 [specific granule membrane]
(Canis familiaris)
Homologues of CD33 [specific granule membrane]
(Danio rerio)
Homologues of CD33 [specific granule membrane]
(Mus musculus)
Homologues of CD33 [specific granule membrane]
(Rattus norvegicus)
Homologues of CD33 [specific granule membrane]
(Sus scrofa)
Homologues of CD33 [specific granule membrane]
(Xenopus tropicalis)
LOC618268 [specific granule membrane]
(Bos taurus)
XB5961956 [specific granule membrane]
(Xenopus tropicalis)
LOC618463 [specific granule membrane]
(Bos taurus)
CD33 [specific granule membrane]
(Canis familiaris)
CD33 [specific granule membrane]
(Danio rerio)
CD33 [specific granule membrane]
(Mus musculus)
CD33 [specific granule membrane]
(Sus scrofa)
CD33 [specific granule membrane]
(Xenopus tropicalis)
LOC101884775 [specific granule membrane]
(Danio rerio)
meis1 [specific granule membrane]
(Xenopus tropicalis)
siglecl1 [specific granule membrane]
(Xenopus tropicalis)
SIGLEC8 [specific granule membrane]
(Bos taurus)
Cd33 [specific granule membrane]
(Rattus norvegicus)
Siglec5 [specific granule membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001171079.1
,
NP_001763.3
,
XP_011525834.1
,
NP_001076087.1
Guide to Pharmacology - Targets
2601
OpenTargets
ENSG00000105383
HPA
ENSG00000105383-CD33
GeneCards
P20138
Ensembl
ENST00000391796
,
ENSP00000375673
,
ENSP00000262262
,
ENSP00000410126
,
ENST00000262262
,
ENST00000421133
,
ENSG00000105383
PRO
P20138
Pharos - Targets
P20138
PDB
5IHB
,
6D48
,
7AW6
,
6D49
,
6D4A
,
5J06
,
5J0B
,
6TL8
HMDB Protein
HMDBP14336
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P29350 PTPN6
5
PTPN6 [tertiary granule lumen]
(R-HSA-6800952)
PTPN6 [extracellular region]
(R-HSA-6806315)
PTPN6 [specific granule lumen]
(R-HSA-6799641)
PTPN6 [nucleoplasm]
(R-HSA-9008911)
PTPN6 [cytosol]
(R-HSA-197938)
0.824
10
UniProt:Q06124 PTPN11
4
p-Y542-PTPN11 [cytosol]
(R-HSA-1369081)
PTPN11 [nucleoplasm]
(R-HSA-8937745)
PTPN11 [cytosol]
(R-HSA-162563)
p-Y542,Y580-PTPN11 [cytosol]
(R-HSA-162573)
0.677
5
UniProt:Q9Y5Z9 UBIAD1
1
UBIAD1 [endoplasmic reticulum membrane]
(R-HSA-2980965)
0.556
3
UniProt:O00767 SCD
1
SCD [endoplasmic reticulum membrane]
(R-HSA-400117)
0.556
3
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