Reactome | CD33 [specific granule membrane]

CD33 [specific granule membrane]

Stable Identifier

R-HSA-6799615

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

specific granule membrane

Synonyms

Myeloid cell surface antigen CD33 precursor, SIGLEC3

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P20138 CD33

Gene Names

CD33, SIGLEC3

Chain

signal peptide:1-17, chain:18-364

Reference Genes

BioGPS Gene:945 CD33

COSMIC (genes):CD33 CD33

CTD Gene:945 CD33

dbSNP Gene:945 CD33

ENSEMBL:ENSG00000105383 CD33

HGNC:1659 CD33

KEGG:hsa:945 CD33

Monarch:945 CD33

NCBI Gene:945 CD33

OMIM:159590 CD33

UCSC:P20138 CD33

Reference Transcript

Other Identifiers

11740961_a_at

11748873_x_at

11762127_at

16864675

206120_PM_at

206120_at

36802_at

3839694

3839701

3839719

3839720

3839721

3839722

3839723

3839724

3839725

3839726

3839727

3839728

3839729

3839730

3839731

3839732

3839733

8030804

945

A_14_P107594

A_14_P137198

A_21_P0000094

A_24_P301655

GE57877

GE809352

GO:0002765

GO:0005515

GO:0005654

GO:0005777

GO:0005794

GO:0005886

GO:0007155

GO:0007165

GO:0007267

GO:0008160

GO:0008285

GO:0009897

GO:0009986

GO:0016020

GO:0019903

GO:0023052

GO:0030246

GO:0032691

GO:0032717

GO:0032720

GO:0033691

GO:0035579

GO:0038023

GO:0038094

GO:0043226

GO:0050714

GO:0060089

GO:0070821

GO:0098609

GO:0098772

GO:0150102

HMNXSV003004904

ILMN_1747622

M23197_at

PH_hs_0004774

PH_hs_0040043

TC19000775.hg

g4502654_3p_at

Participates

as a member of

Specific granule membrane proteins [specific granule membrane] (Homo sapiens)

Other forms of this molecule

CD33 [tertiary granule membrane]

CD33 [plasma membrane]

Inferred To

CD33 [specific granule membrane] (Mus musculus)

LOC100686511 [specific granule membrane] (Canis familiaris)

LOC100138951 [specific granule membrane] (Bos taurus)

siglecl2 [specific granule membrane] (Xenopus tropicalis)

mag [specific granule membrane] (Danio rerio)

Homologues of CD33 [specific granule membrane] (Xenopus tropicalis)

Cd33 [specific granule membrane] (Rattus norvegicus)

LOC110261034 [specific granule membrane] (Sus scrofa)

XB5961956 [specific granule membrane] (Xenopus tropicalis)

Cross References

Guide to Pharmacology - Targets

2601

ENSEMBL

ENST00000262262, ENST00000421133, ENSP00000410126, ENSP00000375673, ENSP00000262262, ENST00000391796

OpenTargets

ENSG00000105383

HPA

ENSG00000105383-CD33

PRO

P20138

Pharos - Targets

P20138

GlyGen

P20138

HMDB Protein

HMDBP14336

PDB

7AW6, 6D48, 6D49, 5J0B, 5J06, 6TL8, 6D4A, 5IHB

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P29350 PTPN6	5	PTPN6 [tertiary granule lumen] (R-HSA-6800952) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [specific granule lumen] (R-HSA-6799641) PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [cytosol] (R-HSA-197938)	0.824	10
UniProt:Q06124 PTPN11	4	p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573) PTPN11 [cytosol] (R-HSA-162563) PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y542-PTPN11 [cytosol] (R-HSA-1369081)	0.677	5
UniProt:O43169 CYB5B	2	CYB5B [endoplasmic reticulum membrane] (R-HSA-9842695) CYB5B [mitochondrial outer membrane] (R-HSA-8943390)	0.556	3
UniProt:Q9Y5Z9 UBIAD1	1	UBIAD1 [endoplasmic reticulum membrane] (R-HSA-2980965)	0.556	3
UniProt:O00767 SCD	1	SCD [endoplasmic reticulum membrane] (R-HSA-400117)	0.556	3
UniProt:P40855 PEX19	1	PEX19 [cytosol] (R-HSA-3009036)	0.527	2

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