The phosphorylated ITIMs of CD22 facilitates recruitment of the tyrosine phosphatase SHP1 (Src homology region 2 domain-containing phosphatase-1 also referred as PTPN6/Tyrosine-protein phosphatase non-receptor type 6), which down modulates BCR signalling (Doody et al. 1995). Activation of SHP1 regulates the strength of the BCR-induced Ca+2 signal. Regulation of Ca+2 signalling occurs both by dephosphorylation of intracellular SHP1 substrates which are important for triggering of Ca+2 signals (Adachi et al. 2001, Stebbins et al. 2003), as well as by a SHP1 dependent activation of the Ca+2 plasma membrane pump PMCA4 which controls termination of the signal (Muller et al. 2013, Ghosh et al. 2006).
Thomas, ML, Doody, GM, Matthews, RJ, Justement, LB, Lin, J, Delibrias, CC, Fearon, DT
Blasioli, J, Thomas, ML, Paust, S
Angermüller, S, Brandl, C, Maity, PC, Müller, J, Obermeier, I, Nitschke, L, Reth, M, Mrotzek, S, Wöhner, M
© 2023 Reactome
