Reactome | CD33 [tertiary granule membrane]

CD33 [tertiary granule membrane]

Stable Identifier

R-HSA-6800959

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

tertiary granule membrane

Synonyms

Myeloid cell surface antigen CD33 precursor, SIGLEC3

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P20138 CD33

Gene Names

CD33, SIGLEC3

Chain

signal peptide:1-17, chain:18-364

Reference Genes

BioGPS Gene:945 CD33

COSMIC (genes):CD33 CD33

CTD Gene:945 CD33

dbSNP Gene:945 CD33

ENSEMBL:ENSG00000105383 CD33

HGNC:1659 CD33

KEGG Gene (Homo sapiens):945 CD33

Monarch:945 CD33

NCBI Gene:945 CD33

OMIM:159590 CD33

UCSC:P20138 CD33

Reference Transcript

Other Identifiers

11740961_a_at

11748873_x_at

16864675

206120_at

36802_at

3839701

3839719

3839720

3839722

3839723

3839724

3839725

3839727

3839729

3839730

3839731

8030804

945

A_14_P137198

A_21_P0000094

A_24_P301655

GE57877

GO:0002376

GO:0002765

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005777

GO:0005794

GO:0005886

GO:0005887

GO:0006464

GO:0006810

GO:0007155

GO:0007165

GO:0007267

GO:0008150

GO:0008283

GO:0008285

GO:0009897

GO:0015031

GO:0016020

GO:0016021

GO:0016192

GO:0019899

GO:0019903

GO:0030246

GO:0031410

GO:0032691

GO:0032717

GO:0032720

GO:0033691

GO:0035579

GO:0038023

GO:0043167

GO:0043226

GO:0043312

GO:0050714

GO:0050776

GO:0051926

GO:0070821

GO:0098609

GO:0150102

GO:1903615

ILMN_1747622

M23197_at

PH_hs_0004774

g4502654_3p_at

Participant Of

hasMember

Tertiary granule membrane proteins [tertiary granule membrane]

Other forms of this molecule

CD33 [specific granule membrane]

CD33 [plasma membrane]

Inferred To

LOC100515551 [tertiary granule membrane] (Sus scrofa)

siglecl2 [tertiary granule membrane] (Xenopus tropicalis)

LOC100686511 [tertiary granule membrane] (Canis familiaris)

Homologues of CD33 [tertiary granule membrane] (Xenopus tropicalis)

si:dkey-238d18.5 [tertiary granule membrane] (Danio rerio)

meis1 [tertiary granule membrane] (Xenopus tropicalis)

acmsd [tertiary granule membrane] (Xenopus tropicalis)

erg [tertiary granule membrane] (Xenopus tropicalis)

SIGLEC8 [tertiary granule membrane] (Bos taurus)

siglecl1 [tertiary granule membrane] (Xenopus tropicalis)

CD33 [tertiary granule membrane] (Xenopus tropicalis)

Siglec5 [tertiary granule membrane] (Mus musculus)

Siglec5 [tertiary granule membrane] (Rattus norvegicus)

npnt [tertiary granule membrane] (Xenopus tropicalis)

XB5994085 [tertiary granule membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001076087.1, XP_011525834.1, NP_001763.3, NP_001171079.1

OpenTargets

ENSG00000105383

GeneCards

P20138

HPA

ENSG00000105383-CD33

Ensembl

ENSP00000262262, ENSG00000105383, ENST00000262262, ENSP00000410126, ENST00000421133, ENST00000391796, ENSP00000375673

PRO

P20138

PDB

6TL8, 5IHB, 5J06, 6D48, 6D49, 6D4A, 5J0B

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P29350 PTPN6	5	PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [specific granule lumen] (R-HSA-6799641) PTPN6 [tertiary granule lumen] (R-HSA-6800952) PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [cytosol] (R-HSA-197938)	0.824	10
UniProt:Q06124 PTPN11	4	PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y546-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [cytosol] (R-HSA-162563) p-Y546,Y584-PTPN11 [cytosol] (R-HSA-162573)	0.677	5
UniProt:Q9Y5Z9 UBIAD1	1	UBIAD1 [endoplasmic reticulum membrane] (R-HSA-2980965)	0.556	3
UniProt:O00767 SCD	1	SCD [endoplasmic reticulum membrane] (R-HSA-400117)	0.556	3

Cite Us!