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p-Y-IL4R [plasma membrane]
Stable Identifier
R-HSA-6786087
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
IL4RA, Interleukin-4 receptor alpha chain, IL4RA_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Homo sapiens)
IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R [plasma membrane] (Homo sapiens)
IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R [plasma membrane] (Homo sapiens)
JAK1 phosphorylates STAT3,STAT6 (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R [plasma membrane] (Homo sapiens)
STAT1,STAT3,STAT6 bind IL13:IL13R type II (Homo sapiens)
IL13-bound tyrosine-phosphorylated IL13 receptor type II with STAT1,STAT3,STAT6 [plasma membrane] (Homo sapiens)
IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R [plasma membrane] (Homo sapiens)
IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R [plasma membrane] (Homo sapiens)
STAT1,STAT3,STAT6 phosphorylation (Homo sapiens)
IL13-bound tyrosine-phosphorylated IL13 receptor type II with STAT1,STAT3,STAT6 [plasma membrane] (Homo sapiens)
IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R [plasma membrane] (Homo sapiens)
IL13-bound tyrosine-phosphorylated IL13 receptor type II with phosphorylated STAT1,STAT3,STAT6 [plasma membrane] (Homo sapiens)
IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R [plasma membrane] (Homo sapiens)
STAT3,STAT6 bind p-Y-IL4R (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R [plasma membrane] (Homo sapiens)
p-Y-STATs dissociate (Homo sapiens)
IL13-bound tyrosine-phosphorylated IL13 receptor type II with phosphorylated STAT1,STAT3,STAT6 [plasma membrane] (Homo sapiens)
IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R [plasma membrane] (Homo sapiens)
IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R [plasma membrane] (Homo sapiens)
p-Y705-STAT3,p-Y641-STAT6 dissociate (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P24394 IL4R
Gene Names
IL4R, IL4RA, 582J2.1
Chain
signal peptide:1-25, chain:26-825, chain:26-
Reference Genes
BioGPS Gene:3566 IL4R
COSMIC (genes):IL4R IL4R
CTD Gene:3566 IL4R
dbSNP Gene:3566 IL4R
ENSEMBL:ENSG00000077238 IL4R
ENSEMBL_homo_sapiens_GENE:ENSG00000077238.14 IL4R
HGNC:6015 IL4R
KEGG Gene (Homo sapiens):3566 IL4R
Monarch:3566 IL4R
NCBI Gene:3566 IL4R
OMIM:147781 IL4R
UCSC:P24394 IL4R
Reference Transcript
RefSeq:NM_000418.3 IL4R
RefSeq:XM_011545827.2 IL4R
RefSeq:XM_011545825.1 IL4R
RefSeq:XM_011545826.2 IL4R
RefSeq:NM_001257406.1 IL4R
RefSeq:NM_001257407.1 IL4R
Other Identifiers
11718073_at
11718074_a_at
11718075_at
11742511_a_at
11748724_a_at
16817254
203233_PM_at
203233_at
3566
3654176
3654183
3654186
3654187
3654189
3654190
3654195
3654200
3654201
3654202
3654206
3654207
3654210
3654211
3654212
3654213
3654214
3654215
3654216
3654217
404_at
7994280
A_23_P129556
A_33_P3349045
A_33_P3395947
GE53990
GO:0002376
GO:0002532
GO:0002639
GO:0004896
GO:0004913
GO:0005515
GO:0005576
GO:0005634
GO:0005654
GO:0005815
GO:0005856
GO:0005886
GO:0006954
GO:0006955
GO:0007155
GO:0007165
GO:0009897
GO:0016020
GO:0016064
GO:0016192
GO:0019221
GO:0023052
GO:0030154
GO:0032722
GO:0034451
GO:0035771
GO:0042832
GO:0043032
GO:0043226
GO:0043235
GO:0043306
GO:0045063
GO:0045064
GO:0045626
GO:0045630
GO:0048856
GO:0060089
GO:0098542
GO:0120162
GO:1901741
HMNXSV003009200
HMNXSV003012450
ILMN_1652185
PH_hs_0004340
TC16000293.hg
X52425_at
g4557668_3p_at
Participates
as a component of
p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
Other forms of this molecule
IL4R [plasma membrane]
Inferred To
phospho-p-Y-IL4R [plasma membrane]
(Gallus gallus)
phospho-Il4r [plasma membrane]
(Mus musculus)
phospho-Il4r [plasma membrane]
(Rattus norvegicus)
phospho-IL4R [plasma membrane]
(Bos taurus)
phospho-IL4R [plasma membrane]
(Canis familiaris)
phospho-IL4R [plasma membrane]
(Sus scrofa)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001244336.1
,
NP_000409.1
,
XP_011544128.1
,
NP_001244335.1
,
XP_011544127.1
,
XP_011544129.1
Guide to Pharmacology - Targets
1697
OpenTargets
ENSG00000077238
GeneCards
P24394
HPA
ENSG00000077238-IL4R
Ensembl
ENST00000395762
,
ENSP00000379111
,
ENSG00000077238
,
ENSP00000441667
,
ENST00000170630
,
ENSP00000170630
,
ENST00000543915
PRO
P24394
Pharos - Targets
P24394
PDB
3BPO
,
1IAR
,
3BPL
,
1IRS
,
6OEL
,
6WGL
,
5E4E
,
3BPN
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05112 IL4
1
IL4 [extracellular region]
(R-HSA-447110)
0.811
7
UniProt:P31785 IL2RG
4
IL2RG [plasma membrane]
(R-HSA-449139)
p-Y-IL2RG [plasma membrane]
(R-HSA-6786103)
p-Y-IL2RG [cytosol]
(R-HSA-9009721)
IL2RG [endosome]
(R-HSA-8983165)
0.667
5
UniProt:P42226 STAT6
6
p-S407,Y641-STAT6 [nucleoplasm]
(R-HSA-3261241)
p-S407,Y641-STAT6 [cytosol]
(R-HSA-3249376)
p-S407-STAT6 [cytosol]
(R-HSA-3249369)
STAT6 [cytosol]
(R-HSA-629625)
p-Y641-STAT6 [nucleoplasm]
(R-HSA-6786279)
p-Y641-STAT6 [cytosol]
(R-HSA-6786109)
0.643
4
UniProt:P78552 IL13RA1
2
IL13RA1 [plasma membrane]
(R-HSA-449671)
p-Y-IL13RA1 [plasma membrane]
(R-HSA-6786750)
0.558
4
UniProt:Q969Z4 TR19L
0.527
2
UniProt:Q99640 PKMYT1
3
PKMYT1 [cytosol]
(R-HSA-157457)
p-PKMYT1 [nucleoplasm]
(R-HSA-162650)
PKMYT1 [nucleoplasm]
(R-HSA-74386)
0.527
2
UniProt:Q96HE9 PRR11
0.527
2
UniProt:Q9NYH9 UTP6
1
UTP6 [nucleoplasm]
(R-HSA-6790674)
0.527
2
UniProt:Q9Y397 ZDHHC9
1
ZDHHC9 [Golgi membrane]
(R-HSA-9647931)
0.527
2
UniProt:O94955 RHOBTB3
1
RHOBTB3 [trans-Golgi network membrane]
(R-HSA-6813908)
0.527
2
UniProt:Q86XL3 ANKLE2
2
ANKLE2 [endoplasmic reticulum membrane]
(R-HSA-2529000)
Ac-K302-ANKLE2 [endoplasmic reticulum membrane]
(R-HSA-9667946)
0.527
2
UniProt:P29597 TYK2
5
p-TYK2 [cytosol]
(R-HSA-8950424)
p-Y-TYK2 [cytosol]
(R-HSA-6784366)
TYK2 [cytosol]
(R-HSA-877348)
p-Y1054,Y1055-TYK2 [cytosol]
(R-HSA-909682)
p-Y1054-TYK2 [cytosol]
(R-HSA-1112598)
0.527
2
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.527
2
UniProt:P23458 JAK1
6
p-Y1034,Y1035-JAK1 [cytosol]
(R-HSA-9005335)
JAK1 [endosome]
(R-HSA-8983168)
p-JAK1 [cytosol]
(R-HSA-8950711)
p-Y1034-JAK1 [cytosol]
(R-HSA-1112543)
JAK1 [cytosol]
(R-HSA-451898)
p-Y-JAK1 [cytosol]
(R-HSA-451921)
0.527
2
UniProt:P29350 PTPN6
5
PTPN6 [specific granule lumen]
(R-HSA-6799641)
PTPN6 [extracellular region]
(R-HSA-6806315)
PTPN6 [tertiary granule lumen]
(R-HSA-6800952)
PTPN6 [nucleoplasm]
(R-HSA-9008911)
PTPN6 [cytosol]
(R-HSA-197938)
0.527
2
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