Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PTPN6 [cytosol]
Stable Identifier
R-RNO-197938
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
P81718
Locations in the PathwayBrowser
Expand all
Hemostasis (Rattus norvegicus)
Cell surface interactions at the vascular wall (Rattus norvegicus)
PECAM1 interactions (Rattus norvegicus)
Interaction of PECAM-1 and SHP-1 (Rattus norvegicus)
PECAM-1:SHP-1 complex [plasma membrane] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
GPVI-mediated activation cascade (Rattus norvegicus)
G6B binds PTPN6,PTPN11 (Rattus norvegicus)
G6B:PTPN6,PTPN11 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
SYK autophosphorylates (Rattus norvegicus)
G6B:PTPN6,PTPN11 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
p-Y7-CLEC1B dimer:PDPN binds SYK (Rattus norvegicus)
G6B:PTPN6,PTPN11 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Platelet homeostasis (Rattus norvegicus)
Platelet sensitization by LDL (Rattus norvegicus)
Interaction of PECAM-1 and SHP-1 (Rattus norvegicus)
PECAM-1:SHP-1 complex [plasma membrane] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Regulation of T cell activation by CD28 family (Rattus norvegicus)
Co-inhibition by BTLA (Rattus norvegicus)
SHP-1 and SHP-2 bind pBTLA (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
SHP-1/SHP-2:pBTLA:HVEM [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Co-inhibition by PD-1 (Rattus norvegicus)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Interaction of SHP-1 or SHP-2 with phospho PD-1 (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Signaling by the B Cell Receptor (BCR) (Rattus norvegicus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Rattus norvegicus)
SYK autophosphorylates at the activated BCR (Rattus norvegicus)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
CD22 mediated BCR regulation (Rattus norvegicus)
SHP1 binds p-CD22 (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Interferon Signaling (Rattus norvegicus)
Interferon alpha/beta signaling (Rattus norvegicus)
Regulation of IFNA/IFNB signaling (Rattus norvegicus)
Dephosphorylation of JAK1 by SHP1 (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Interferon gamma signaling (Rattus norvegicus)
Transphosphorylation of JAK1 (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-2 family signaling (Rattus norvegicus)
Interleukin receptor SHC signaling (Rattus norvegicus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Rattus norvegicus)
Interleukin receptor SHC signaling (Rattus norvegicus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
SHP1 and SHP2 bind the common beta chain (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by ALK (Rattus norvegicus)
PTPN6 dephosphorylates JAK3 (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
Signaling by SCF-KIT (Rattus norvegicus)
Regulation of KIT signaling (Rattus norvegicus)
Interaction of SHP1 and KIT (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
PTPN6:p-c-Kit complex [plasma membrane] (Rattus norvegicus)
PTPN6 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P81718
Reference Genes
BioGPS Gene:116689
ENSEMBL:ENSRNOG00000014294
KEGG:rno:116689
Monarch:116689
NCBI Gene:116689
UCSC:P81718
Reference Transcript
RefSeq:NM_053908.2
Participates
as an input of
Interaction of SHP1 and KIT (Rattus norvegicus)
Interaction of PECAM-1 and SHP-1 (Rattus norvegicus)
SHP1 binds p-CD22 (Rattus norvegicus)
as a component of
PTPN6:p-c-Kit complex [plasma membrane] (Rattus norvegicus)
PECAM-1:SHP-1 complex [plasma membrane] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Rattus norvegicus)
as a member of
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
This entity regulates
Negatively
Transphosphorylation of JAK1
(Rattus norvegicus)
Other forms of this molecule
PTPN6 [specific granule lumen]
PTPN6 [extracellular region]
PTPN6 [tertiary granule lumen]
Inferred From
PTPN6 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_446360.2
PRO
P81718
RGD
620660
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text