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PTPN6 [cytosol]
Stable Identifier
R-GGA-197938
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
A0A3Q2UET2
Locations in the PathwayBrowser
Expand all
Hemostasis (Gallus gallus)
Cell surface interactions at the vascular wall (Gallus gallus)
PECAM1 interactions (Gallus gallus)
Interaction of PECAM-1 and SHP-1 (Gallus gallus)
PECAM-1:SHP-1 complex [plasma membrane] (Gallus gallus)
PTPN6 [cytosol] (Gallus gallus)
PTPN6 [cytosol] (Gallus gallus)
Platelet homeostasis (Gallus gallus)
Platelet sensitization by LDL (Gallus gallus)
Interaction of PECAM-1 and SHP-1 (Gallus gallus)
PECAM-1:SHP-1 complex [plasma membrane] (Gallus gallus)
PTPN6 [cytosol] (Gallus gallus)
PTPN6 [cytosol] (Gallus gallus)
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Regulation of T cell activation by CD28 family (Gallus gallus)
Co-inhibition by PD-1 (Gallus gallus)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Gallus gallus)
PTPN6,PTPN11 [cytosol] (Gallus gallus)
PTPN6 [cytosol] (Gallus gallus)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Gallus gallus)
PTPN6,PTPN11 [cytosol] (Gallus gallus)
PTPN6 [cytosol] (Gallus gallus)
Interaction of SHP-1 or SHP-2 with phospho PD-1 (Gallus gallus)
PTPN6,PTPN11 [cytosol] (Gallus gallus)
PTPN6 [cytosol] (Gallus gallus)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Gallus gallus)
PTPN6,PTPN11 [cytosol] (Gallus gallus)
PTPN6 [cytosol] (Gallus gallus)
Signaling by the B Cell Receptor (BCR) (Gallus gallus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Gallus gallus)
SYK autophosphorylates at the activated BCR (Gallus gallus)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Gallus gallus)
PTPN6 [cytosol] (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Interferon Signaling (Gallus gallus)
Interferon alpha/beta signaling (Gallus gallus)
Regulation of IFNA/IFNB signaling (Gallus gallus)
Dephosphorylation of JAK1 by SHP1 (Gallus gallus)
PTPN6 [cytosol] (Gallus gallus)
Interferon gamma signaling (Gallus gallus)
Transphosphorylation of JAK1 (Gallus gallus)
PTPN6 [cytosol] (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-2 family signaling (Gallus gallus)
Interleukin receptor SHC signaling (Gallus gallus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Gallus gallus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Gallus gallus)
PTPN6 [cytosol] (Gallus gallus)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Gallus gallus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Gallus gallus)
PTPN6 [cytosol] (Gallus gallus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Gallus gallus)
Interleukin receptor SHC signaling (Gallus gallus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Gallus gallus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Gallus gallus)
PTPN6 [cytosol] (Gallus gallus)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Gallus gallus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Gallus gallus)
PTPN6 [cytosol] (Gallus gallus)
SHP1 and SHP2 bind the common beta chain (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Gallus gallus)
PTPN6,PTPN11 [cytosol] (Gallus gallus)
PTPN6 [cytosol] (Gallus gallus)
PTPN6,PTPN11 [cytosol] (Gallus gallus)
PTPN6 [cytosol] (Gallus gallus)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Gallus gallus)
PTPN6,PTPN11 [cytosol] (Gallus gallus)
PTPN6 [cytosol] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Gallus gallus)
PTPN6,PTPN11 [cytosol] (Gallus gallus)
PTPN6 [cytosol] (Gallus gallus)
PTPN6,PTPN11 [cytosol] (Gallus gallus)
PTPN6 [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by SCF-KIT (Gallus gallus)
Regulation of KIT signaling (Gallus gallus)
Interaction of SHP1 and KIT (Gallus gallus)
PTPN6 [cytosol] (Gallus gallus)
PTPN6:p-c-Kit complex [plasma membrane] (Gallus gallus)
PTPN6 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A3Q2UET2
Reference Genes
ENSEMBL:ENSGALG00000014561
UCSC:A0A3Q2UET2
Participates
as a component of
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Gallus gallus)
PTPN6:p-c-Kit complex [plasma membrane] (Gallus gallus)
PECAM-1:SHP-1 complex [plasma membrane] (Gallus gallus)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Gallus gallus)
as an input of
Interaction of SHP1 and KIT (Gallus gallus)
Interaction of PECAM-1 and SHP-1 (Gallus gallus)
as a member of
PTPN6,PTPN11 [cytosol] (Gallus gallus)
This entity regulates
Negatively
Transphosphorylation of JAK1
(Gallus gallus)
Other forms of this molecule
PTPN6 [tertiary granule lumen]
PTPN6 [extracellular region]
PTPN6 [specific granule lumen]
Inferred From
PTPN6 [cytosol]
(Homo sapiens)
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