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About
What is Reactome ?
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Digital Preservation
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p-8Y-EPOR [plasma membrane]
Stable Identifier
R-HSA-9006274
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Erythropoietin receptor, EPOR_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Erythropoietin (Homo sapiens)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI3K bound to EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
Erythropoietin activates Phospholipase C gamma (PLCG) (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PLCG1,2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-PLCG1,2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PLCG1,2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-PLCG1,2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
Erythropoietin activates RAS (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:SHC1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:SOS1,p-Y-VAV1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:p-Y-VAV1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:SHC1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:p-Y-VAV1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
Erythropoietin activates STAT5 (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:STAT5 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:STAT5 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-STAT5 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-STAT5 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
Phospho-JAK2 phosphorylates EPOR (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P19235 EPOR
Gene Names
EPOR
Chain
signal peptide:1-24, chain:25-508
Reference Genes
BioGPS Gene:2057 EPOR
COSMIC (genes):EPOR EPOR
CTD Gene:2057 EPOR
dbSNP Gene:2057 EPOR
ENSEMBL:ENSG00000187266 EPOR
ENSEMBL_homo_sapiens_GENE:ENSG00000187266.14 EPOR
HGNC:3416 EPOR
KEGG Gene (Homo sapiens):2057 EPOR
Monarch:2057 EPOR
NCBI Gene:2057 EPOR
OMIM:133171 EPOR
UCSC:P19235 EPOR
Reference Transcript
RefSeq:NM_000121.3 EPOR
Other Identifiers
1087_at
11740081_a_at
16868928
2057
209962_PM_at
209962_at
209963_PM_s_at
209963_s_at
215054_3p_at
215054_PM_at
215054_at
37986_PM_at
37986_at
3850860
3850861
3850862
3850863
3850864
3850870
3850872
3850874
3850875
3850876
3850879
3850882
3850883
396_3p_f_at
396_PM_f_at
396_f_at
4876922C_3p_at
8034217
A_23_P367899
A_23_P381954
GE58209
GO:0004888
GO:0004896
GO:0004900
GO:0005515
GO:0005576
GO:0005634
GO:0005654
GO:0005886
GO:0007165
GO:0007420
GO:0007507
GO:0008284
GO:0009897
GO:0016020
GO:0016607
GO:0019221
GO:0022414
GO:0023052
GO:0030097
GO:0030154
GO:0038162
GO:0042802
GO:0043226
GO:0046697
GO:0048856
GO:0060089
HMNXSV003015443
Hs.89548.1.S1_3p_s_at
ILMN_2168347
M60459_at
PH_hs_0007355
TC19002335.hg
TC19002676.hg
X97671cds_3p_s_at
g182200_3p_at
g182200_3p_x_at
Participates
as a component of
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
Other forms of this molecule
EPOR [plasma membrane]
Inferred From
p-8Y-Epor [plasma membrane]
(Mus musculus)
Inferred To
phospho-Epor [plasma membrane]
(Mus musculus)
phospho-Epor [plasma membrane]
(Rattus norvegicus)
phospho-EPOR [plasma membrane]
(Bos taurus)
phospho-EPOR [plasma membrane]
(Canis familiaris)
phospho-EPOR [plasma membrane]
(Sus scrofa)
phospho-epor [plasma membrane]
(Xenopus tropicalis)
Ghost homologue of p-8Y-EPOR [plasma membrane]
(Drosophila melanogaster)
Modified Residues
Name
O4'-phospho-L-tyrosine at 368
Coordinate
368
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 426
Coordinate
426
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 454
Coordinate
454
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 456
Coordinate
456
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 468
Coordinate
468
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 485
Coordinate
485
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 489
Coordinate
489
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 504
Coordinate
504
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_000112.1
Guide to Pharmacology - Targets
1718
OpenTargets
ENSG00000187266
ZINC - Substances
EPOR_HUMAN
ZINC target
P19235
PRO
P19235
PDB
6MOH
,
4Y5Y
,
6E2Q
,
6MOK
,
6I4X
,
1EBP
,
6MOL
,
1CN4
,
6MOF
,
4Y5X
,
1EER
,
6MOE
,
4Y5V
,
1ERN
,
1EBA
,
6MOJ
,
2JIX
,
2MV6
,
6MOI
GeneCards
P19235
HPA
ENSG00000187266-EPOR
Ensembl
ENSP00000222139
,
ENST00000592375
,
ENST00000222139
,
ENSG00000187266
,
ENSP00000467809
Pharos - Targets
P19235
Orphanet
15987
ZINC - Predictions - Purchasable
EPOR_HUMAN
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P29350 PTPN6
5
PTPN6 [specific granule lumen]
(R-HSA-6799641)
PTPN6 [extracellular region]
(R-HSA-6806315)
PTPN6 [tertiary granule lumen]
(R-HSA-6800952)
PTPN6 [nucleoplasm]
(R-HSA-9008911)
PTPN6 [cytosol]
(R-HSA-197938)
0.8
11
UniProt:P01588 EPO
1
EPO [extracellular region]
(R-HSA-379001)
0.609
3
UniProt:P18031 PTPN1
2
PTPN1 [cytosol]
(R-HSA-210625)
PTPN1 [endosome membrane]
(R-HSA-9815895)
0.602
3
UniProt:Q92835 INPP5D
2
p-Y-INPP5D [cytosol]
(R-HSA-9680730)
INPP5D [cytosol]
(R-HSA-197940)
0.547
2
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