DNMT1-dependent PTPN6 gene silencing

Stable Identifier
R-HSA-9851072
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
DNMT1-dependent PTPN6 gene silencing
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PTPN6, also known as SHP1, is a protein tyrosine phosphatase that is repressed in cutaneous T-cell lymphomas and ALK+ T-cell lymphomas in a manner that depends on STAT3, HDAC1 and DNMT1 (Zhang et al, 2005).
Literature References
PubMed ID Title Journal Year
15870198 STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes

Wasik, MA, Zhang, Q, Wang, HY, Marzec, M, Raghunath, PN, Nagasawa, T

Proc Natl Acad Sci U S A 2005
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
pY705, S727 STAT dimer:DNMT1:HDAC1:PTPN6 gene [nucleoplasm] (Homo sapiens)
Active Unit
HDAC1 [nucleoplasm]
DNMT1 [nucleoplasm]
p-Y705,S727-STAT3 [nucleoplasm]
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
cutaneous T cell lymphoma DOID:0060061 cutaneous T-cell lymphoma
Authored
Rothfels, K  (2023-10-14)
Reviewed
Turner, S  (2023-11-08)
Created
Rothfels, K  (2023-10-12)
Cite Us!