p-8Y-FGFR2 K660E [plasma membrane]

Stable Identifier
R-HSA-2033298
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Icon
p-8Y-FGFR2 K660E [plasma membrane] icon
p-8Y-FGFR2 K660E [plasma membrane] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
17525745 Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes

Futreal, PA, Pollock, PM, Goodfellow, PJ, Gartside, MG, Stratton, MR, Davies, H, Mallon, MA, Mohammadi, M, Dejeza, LC, Powell, MA, Trent, JM

Oncogene 2007
External Reference Information
External Reference
UniProt:P21802 FGFR2
Gene Names
FGFR2, BEK, KGFR, KSAM
Chain
signal peptide:1-21, chain:22-821
Reference Genes
ENSEMBL:ENSG00000066468 FGFR2
Participates
as a component of
Other forms of this molecule
FGFR2 IIIa TM [extracellular region]
FGFR2 [plasma membrane]
FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane]
FGFR2(2-822)-CIT(927-2027) fusion [plasma membrane]
FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane]
FGFR2(22-767)-AHCYL1(108-530) fusion [plasma membrane]
FGFR2(22-767)-OFD1(38-1012) fusion [plasma membrane]
FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane]
FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane]
FGFR2(22-767)-CCAR(51-923) fusion [plasma membrane]
FGFR2 N549H [plasma membrane]
FGFR2 N549K [plasma membrane]
FGFR2 K660N [plasma membrane]
p-8Y-FGFR2 K660M [plasma membrane]
phosphorylated FGFR2 L764Hfs*4 [plasma membrane]
p-8Y-FGFR2 W290C [plasma membrane]
p-8Y-FGFR2 S267P [plasma membrane]
p-8Y-FGFR2 [plasma membrane]
p-8Y-FGFR2 N549K [plasma membrane]
p-8Y-FGFR2 N549H [plasma membrane]
p-8Y-FGFR2 K660N [plasma membrane]
p-6Y-FGFR2(22-767)-CCAR(51-923) fusion [plasma membrane]
p-6Y-FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane]
p-6Y-FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane]
p-6Y-FGFR2(22-767)-OFD1(38-1012) fusion [plasma membrane]
p-6Y-FGFR2(22-767)-AHCYL1(108-530) fusion [plasma membrane]
p-6Y-FGFR2(2-822)-CIT(927-2027) fusion [plasma membrane]
p-6Y-FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane]
p-6Y-FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane]
FGFR2 W290C [plasma membrane]
FGFR2 L764Hfs*4 [plasma membrane]
FGFR2 S267P [plasma membrane]
FGFR2 K660E [plasma membrane]
FGFR2 K660M [plasma membrane]
Inferred From
p-6Y-FGFR3 K650E [plasma membrane] (Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
L-lysine 660 replaced with L-glutamic acid
Coordinate
660
PsiMod
L-glutamic acid residue [MOD:00015]
A protein modification that effectively converts a source amino acid residue to an L-glutamic acid.
L-lysine removal [MOD:01642]
A protein modification that effectively removes or replaces an L-lysine.
Disease
Name Identifier Synonyms
female reproductive endometrioid cancer DOID:3001 endometrioid tumor (morphologic abnormality), endometrioid neoplasm
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
COSMIC
Interactors (30)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P09038 FGF2  1 0.779 5
 UniProt:P51812 RPS6KA3  7 0.745 5
 UniProt:P62993 GRB2  1 0.735 6
 ChEBI:73280 SSR      0.683 8
 UniProt:P05230 FGF1  1 0.675 3
 UniProt:P11362 FGFR1  9 0.623 3
 UniProt:O15520 FGF10  1 0.571 2
 UniProt:P19174 PLCG1  6 0.528 3
 UniProt:Q3MIR4 CC50B      0.527 2
 UniProt:O60637 TSN3      0.527 2
 UniProt:Q96LL9 DJC30      0.527 2
 UniProt:Q6P047 CH074      0.527 2
 UniProt:Q99732 LITAF      0.527 2
 UniProt:Q8N7X8 SIGL1      0.527 2
 UniProt:Q5T9A4 ATAD3B  3 0.527 2
 UniProt:Q96HB5 CC120      0.527 2
 UniProt:Q8IWX8 CHERP  1 0.527 2
 UniProt:Q92551 IP6K1  2 0.527 2
 UniProt:Q6P995 F171B      0.527 2
 UniProt:P34741 SDC2  20 0.527 2
 UniProt:Q92575 UBXN4      0.527 2
 UniProt:Q96L94 SNX22      0.527 2
 UniProt:P01033 TIMP1  4 0.527 2
 UniProt:Q96G30 MRAP2      0.527 2
 UniProt:P55899 FCGRN      0.527 2
 UniProt:Q5TF58 IFFO2      0.527 2
 UniProt:Q06124 PTPN11  4 0.519 2
 UniProt:Q9ULH0 KIDINS220  2 0.483 2
 UniProt:Q9UBH6 S53A1      0.483 2
 UniProt:Q86VI4 LAP4B      0.463 2
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