FGFR4 N535D [plasma membrane]

Stable Identifier
R-HSA-1614427
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Icon
FGFR4 N535D [plasma membrane] icon
FGFR4 N535D [plasma membrane] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
19809159 Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models

Chanock, SJ, Cheuk, AT, Catchpoole, D, Desai, K, Chung, JY, Chen, QR, Hewitt, SM, Fang, J, Helman, LJ, Khan, J, Kim, S, Merlino, G, Khanna, C, Mendoza, A, Ngo, V, Tsang, PS, Staudt, LM, Taylor JG, 6th, Song, YK, Shah, K, Qualman, SJ, Wei, JS, Yeung, C, Youngblood, V, Yu, Y

J Clin Invest 2009
External Reference Information
External Reference
UniProt:P22455 FGFR4
Gene Names
FGFR4, JTK2, TKF
Chain
signal peptide:1-21, chain:22-802
Reference Genes
BioGPS Gene:2264 FGFR4
COSMIC (genes):FGFR4 FGFR4
CTD Gene:2264 FGFR4
dbSNP Gene:2264 FGFR4
ENSEMBL:ENSG00000160867 FGFR4
ENSEMBL_homo_sapiens_GENE:ENSG00000160867.15 FGFR4
HGNC:3691 FGFR4
KEGG Gene (Homo sapiens):2264 FGFR4
Monarch:2264 FGFR4
NCBI Gene:2264 FGFR4
OMIM:134935 FGFR4
UCSC:P22455 FGFR4
Reference Transcript
Other Identifiers
11735873_a_at
11740240_a_at
11744657_x_at
11752172_a_at
11753528_a_at
11757181_x_at
1291_s_at
1554962_PM_a_at
1554962_a_at
16992957
204579_PM_at
204579_at
211237_PM_s_at
211237_s_at
2264
2842912
2842913
2842914
2842915
2842916
2842918
2842920
2842922
2842923
2842924
2842926
2842928
2842930
2842931
2842932
2842933
2842934
2842935
2842936
2842938
2842939
2842941
2842943
2842944
8110265
A_14_P131381
A_23_P92754
GO:0000166
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005007
GO:0005515
GO:0005524
GO:0005576
GO:0005768
GO:0005783
GO:0005794
GO:0005886
GO:0005911
GO:0006468
GO:0006629
GO:0007169
GO:0008201
GO:0008284
GO:0008543
GO:0010628
GO:0010715
GO:0016020
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0017134
GO:0018108
GO:0019216
GO:0023052
GO:0030133
GO:0030198
GO:0031410
GO:0036211
GO:0042593
GO:0042632
GO:0043085
GO:0043226
GO:0043235
GO:0045862
GO:0046777
GO:0048870
GO:0055062
GO:0060089
GO:0070374
GO:0070857
GO:0140096
GO:2000573
HMNXSV003054104
ILMN_1730355
ILMN_2241412
ILMN_2410713
L03840_s_at
PH_hs_0010000
TC05001010.hg
g13112051_3p_at
g6739817_3p_a_at
Participates
as a candidate of
as a component of
Other forms of this molecule
FGFR4 Y367C [plasma membrane]
FGFR4 N535K [plasma membrane]
FGFR4 V550E [plasma membrane]
FGFR4 V550L [plasma membrane]
p-5Y-FGFR4 V550E [plasma membrane]
p-5Y-FGFR4 N535K [plasma membrane]
p-5Y-FGFR4 V550L [plasma membrane]
p-5Y-FGFR4 N535D [plasma membrane]
p5Y-FGFR4 Y367C mutant [plasma membrane]
FGFR4 [plasma membrane]
p-5Y-FGFR4 [plasma membrane]
Modified Residues
Name
L-asparagine 535 replaced with L-aspartic acid
Coordinate
535
PsiMod
L-aspartic acid residue [MOD:00013]
A protein modification that effectively converts a source amino acid residue to an L-aspartic acid.
L-asparagine removal [MOD:01633]
A protein modification that effectively removes or replaces an L-asparagine.
Disease
Name Identifier Synonyms
rhabdomyosarcoma DOID:3247 Rhabdomyosarcoma NOS (morphologic abnormality), rhabdomyosarcoma, Rhabdomyosarcoma, no subtype (morphologic abnormality), rhabdomyoblastoma, Rhabdomyosarcoma (disorder)
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
ZINC - Investigational
GeneCards
HPA
Ensembl
Pharos - Targets
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (8)
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